UNASSIGNED: Functional electrical stimulation (FES) is an established method of supporting neurological rehabilitation. However, particularly on the forearm, it still cannot elicit selective muscle activations that form the basis of complex hand movements. Current research approaches in the context of selective muscle activation often attempt to enable targeted stimulation by increasing the number of electrodes and combining them in electrode arrays. In order to determine the best stimulation positions and settings, manual or semi-automated algorithms are used. This approach is limited due to experimental limitations. The supportive use of simulation studies is well-established, but existing simulation models are not suitable for analyses of selective muscle activation due to missing or arbitrarily arranged innervation zones.
UNASSIGNED: This study introduces a new modeling method to design a person-specific digital twin that enables the prediction of muscle activations during FES on the forearm. The designed individual model consists of three parts: an anatomically based 3D volume conductor, a muscle-specific nerve fiber arrangement in various regions of interest (ROIs), and a standard nerve model. All processes were embedded in scripts or macros to enable automated changes to the model and the simulation setup.
UNASSIGNED: The experimental evaluation of simulated strength-duration diagrams showed good coincidence. The relative differences of the simulated amplitudes to the mean amplitude of the four experiments were in the same range as the inter-experimental differences, with mean values between 0.005 and 0.045. Based on these results, muscle-specific activation thresholds were determined and integrated into the simulation process. With this modification, simulated force-intensity curves showed good agreement with additionally measured curves.
UNASSIGNED: The results show that the model is suitable for simulating realistic muscle-specific activations. Since complex hand movements are physiologically composed of individual, selective muscle activations, it can be assumed that the model is also suitable for simulating these movements. Therefore, this study presents a new and very promising approach for developing new applications and products in the context of the rehabilitation of sensorimotor disorders.

Individual biomathematical models of fatigue (BMMF) are promising tools for detecting fatigue and possible incidents. Existing individual BMMFs have been validated in laboratory experiments in which subjects experience total sleep deprivation (TSD) and regular chronic sleep deprivation (CSD). However, some shift populations experience mild sleep deprivation (MSD) or irregular sleep deprivation (ISD) in real life. We employed the adaptive momentum estimation algorithm to adjust the classical SAFTE model for an individual. Model individualisation can be performed in real-time when new performance data are collected. The individual SAFTE model was compared with existing BMMFs in TSD, CSD, MSD, and ISD. The validation results show that the individual SAFTE model has advantages in MSD and ISD datasets collected from officers and truck drivers in real life. This study expands previous research results on the real-time individualisation of BMMFs and exposes individual BMMFs to various sleep-deprivation conditions in the field. Practitioner summary: This study proposes an individual biomathematical models of fatigue to predict human performance in mild and irregular sleep deprivation. The validation results in both laboratory and field show the proposed model has advantages over existing models when predicting officers\' and truck drivers\' performance in real life.

In this present research, a spectroscopic method based on UV-Vis spectroscopy is utilized to quantify the level of corn adulteration in peaberry ground roasted coffee by chemometrics. Peaberry coffee with two types of bean processing of wet and dry-processed methods was used and intentionally adulterated by corn with a 10-50% level of adulteration. UV-Vis spectral data are obtained for aqueous samples in the range between 250 and 400 nm with a 1 nm interval. Three multivariate regression methods, including partial least squares regression (PLSR), multiple linear regression (MLR), and principal component regression (PCR), are used to predict the level of corn adulteration. The result shows that all individual regression models using individual wet and dry samples are better than that of global regression models using combined wet and dry samples. The best calibration model for individual wet and dry and combined samples is obtained for the PLSR model with a coefficient of determination in the range of 0.83-0.93 and RMSE below 6% (w/w) for calibration and validation. However, the error prediction in terms of RMSEP and bias were highly increased when the individual regression model was used to predict the level of corn adulteration with differences in the bean processing method. The obtained results demonstrate that the use of the global PLSR model is better in predicting the level of corn adulteration. The error prediction for this global model is acceptable with low RMSEP and bias for both individual and combined prediction samples. The obtained RPDp and RERp in prediction for the global PLSR model are more than two and five for individual and combined samples, respectively. The proposed method using UV-Vis spectroscopy with a global PLSR model can be applied to quantify the level of corn adulteration in peaberry ground roasted coffee with different bean processing methods.

Mathematical models of sexually transmitted disease (STI) are increasingly relied on to inform policy, practice, and resource allocation. Because STI transmission requires sexual contact between two or more people, a model\'s ability to represent the dynamics of sexual partnerships can influence the validity of findings. This ability is to a large extent constrained by the model type, as different modeling frameworks vary in their capability to capture patterns of sexual contact at individual, partnership, and network levels. In this paper, we classify models into three groups: compartmental, individual-based, and statistical network models. For each framework, we describe the basic model structure and discuss key aspects of sexual partnership dynamics: how and with whom partnerships are formed, partnership duration and dissolution, and temporal overlap in partnerships (concurrency). We illustrate the potential implications of accurately accounting for partnership dynamics, but these effects depend on characteristics of both the population and pathogen; the combined impact of these partnership and epidemiologic dynamics can be difficult to predict. While each of the reviewed model frameworks may be appropriate to inform certain research or policy questions, modelers and consumers of models should carefully consider the implications of sexual partnership dynamics for the questions under study.

To release the strong dependence of the conventional inertial navigation mechanization on the a priori low-cost inertial measurement unit (IMU) error model, this research applies an unconventional multi-sensor integration strategy to integrate multiple low-cost IMUs and a global positioning system (GPS) for mass-market automotive applications. The unconventional integration strategy utilizes a basic three-dimensional (3D) kinematic trajectory model as the system model to directly estimate navigational parameters, and it allows the measurements from all of the sensors independently participating in measurement updates. However, the less complex kinematic model cannot realize smooth transitions between different motion statuses for the road vehicle with acceleration maneuvers. In this manuscript, we establish a more practical 3D kinematic trajectory model based on a \"current\" statistical Singer acceleration model to realize smooth transitions for the maneuvering vehicle. In addition, taking advantage of the unconventional strategy, we individually model the systematic errors of each IMU and the measurements of all sensors, in contrast to most existing approaches that adopt the common-mode errors for different sensors of the same design. A real dataset involving a GPS and multiple IMUs is processed to validate the success of the proposed algorithm model under the unconventional integration strategy.