Most classical discrete-time population models of interspecific competition have emerged as population-level phenomenological models with no evident basis at the individual level. This study shows that the Hassell-Comins model, a widely used discrete-time model of interspecific competition, can be derived in a bottom-up manner from a simple model of random resource competition between individuals of two species as an expression of expected population sizes in the next generation. The random competition leads to inequalities in resource allocation between individuals, which are related to the key parameters of the Hassell-Comins model that determine the density dependence of each species. The relationship between population-level parameters, such as intra- and interspecific competition coefficients, and individual-level parameters is discussed in detail, as is how the derived competition equations depend on the degree of inequality within each species. By considering limits of maximum or minimum resource inequality within each species, the derived model can describe interspecific competition for various combinations of two species exhibiting ideal scramble or ideal contest intraspecific competition.

UNASSIGNED: The objective structured clinical examination (OSCE) is used extensively in health and medical education to assess clinical competence. While OSCEs are not primarily designed for individual feedback, they provide an opportunity to generate meaningful and constructive feedback that students can use to reflect on areas of weakness (and strength). The most timely and effective way to incorporate individual feedback following a summative OSCE continues to be explored.
UNASSIGNED: This paper describes a novel OSCE feedback model which uses readily available summative assessment data to calculate 10% index scores. This provides information about relative station difficulty and relative individual student performance.
UNASSIGNED: An individualised feedback report was provided to every student after the OSCEs. This enables identification of stronger and weaker performance areas and composite skills, which can be utilised by all students to direct future learning.
UNASSIGNED: Providing timely, individual actionable feedback to every student following a summative OSCE is possible without impacting the examination process or examiner burden.
UNASSIGNED: A study is planned to determine the utilisation of this feedback by students and it\'s impact as a qualitative self-assessment exercise.

UNASSIGNED: The ratio of the index finger (2nd finger) to the ring finger (4th finger) (2D:4D) can give information about harmony between personality and career of individuals. The developing technology makes it difficult to choose a profession.
UNASSIGNED: This study aims to contribute to the career choice of individuals by analyzing the relationship between the 2D:4D finger digit ratio and personality traits of individuals working in different professions (Educator, Worker, Housewife, Civil servant, Healthcare professional/EWHCH).
UNASSIGNED: The participants were three hundred twenty-five individuals living in the province of Malatya. The SPSS 26.0 software was utilized in the data analysis. The p value of 0.05 was accepted as significance level in comparison tests.
UNASSIGNED: A statistically significant difference was determined between the participants, who had the 2D shorter than the 4D in right hand, in terms of professional groups (p < 0.05). In healthcare workers, a low level (r = 0.305) positive correlation was found between right hand 2D4D and both control (r = 0.264) and curiosity and left hand 2D:4D, and a low level (r = 0.255) negative correlation was found between Conscientiousness and right hand 2D:4D in housewives. There was a statistically significant difference between the groups (educator, worker, housewife, civil servant, healthcare professional) in terms of total score of the Five-Factor Personality Inventory (FFPI) and scores of extroversion, agreeableness, conscientiousness, neuroticism, and openness to experience subscales (p < 0.05). A weak positive statistically significant correlation was detected between the healthcare professionals\' score of Career Adapt-abilities Scale (CAAS) control subscale and the right-hand 2D:4D ratio. Conclusions: It is suggested to investigate the 2D:4D ratio over different professional groups. The present study is important since it gives information about personality and associates such information with the 2D:4D ratio.

Schizophrenia is a severe mental illness that significantly impacts the lives of affected individuals and with increasing mortality rates. Early detection and intervention are crucial for improving outcomes but the lack of validated biomarkers poses great challenges in such efforts. The use of magnetic resonance imaging (MRI) in schizophrenia enables the investigation of the disorder\'s etiological and neuropathological substrates in vivo. After decades of research, promising findings of MRI have been shown to aid in screening high-risk individuals and predicting illness onset, and predicting symptoms and treatment outcomes of schizophrenia. The integration of machine learning and deep learning techniques makes it possible to develop intelligent diagnostic and prognostic tools with extracted or selected imaging features. In this review, we aimed to provide an overview of current progress and prospects in establishing clinical utility of MRI in schizophrenia. We first provided an overview of MRI findings of brain abnormalities that might underpin the symptoms or treatment response process in schizophrenia patients. Then, we summarized the ongoing efforts in the computer-aided utility of MRI in schizophrenia and discussed the gap between MRI research findings and real-world applications. Finally, promising pathways to promote clinical translation were provided. EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 3.

Evidence of clinical impact is critical to unlock the potential of digital health solutions (DHSs), yet many solutions are failing to deliver positive clinical results. We argue in this viewpoint that this failure is linked to current approaches to DHS evaluation design, which neglect numerous key characteristics (KCs) requiring specific scientific and design considerations. We first delineate the KCs of DHSs: (1) they are implemented at health care system and patient levels; (2) they are \"complex\" interventions; (3) they can drive multiple clinical outcomes indirectly through a multitude of smaller clinical benefits; (4) their mechanism of action can vary between individuals and change over time based on patient needs; and (5) they develop through short, iterative cycles-optimally within a real-world use context. Following our objective to drive better alignment between clinical evaluation design and the unique traits of DHSs, we then provide methodological suggestions that better address these KCs, including tips on mechanism-of-action mapping, alternative randomization methods, control-arm adaptations, and novel end-point selection, as well as innovative methods utilizing real-world data and platform research.

This study aimed to investigate the ecological system factors that influence discrimination of sarcopenia among older individuals living in contemporary society. Data analysis included information from 618 older adults individuals aged 65 years or older residing in South Korea. To assess variations in ecological system factors related to SARC-F scores, we conducted correlation analysis and t-tests. Discriminant analysis was used to identify factors contributing to group discrimination. The key findings are summarized as follows. First, significant differences at the p < 0.001 level were observed between the SARC-F score groups in various aspects, including attitudes toward life, wisdom in life, health management, social support, media availability, sports environment, collectivist values, and values associated with death. Further, service environment differences were significant at p < 0.01 level, while social belonging and social activities exhibited significance at p < 0.05. Second, factors influencing group discrimination based on the SARC-F scores were ranked in the following order: health management, attitudes toward life, fear of own death, wisdom in life, physical environment, sports environment, media availability, social support, fear of the own dying, collectivist values, service environment, social activities, and social belonging. Notably, the SARC-F tool, which is used for sarcopenia discrimination, primarily concentrates on physical functioning and demonstrates relatively low sensitivity. Therefore, to enhance the precision of sarcopenia discrimination within a score-based group discrimination process, it is imperative to incorporate ecological system factors that exert a significant influence. These modifications aimed to enhance the clarity and precision of the text in an academic context.

Although several previous studies have used resting-state functional magnetic resonance imaging and diffusion tensor imaging to report topological changes in the brain in epilepsy, it remains unclear whether the individual structural covariance network (SCN) changes in epilepsy, especially in pediatric epilepsy with visual cortex resection but with normal functions. Herein, individual SCNs were mapped and analyzed for seven pediatric patients with epilepsy after surgery and 15 age-matched healthy controls. A whole-brain individual SCN was constructed based on an automated anatomical labeling template, and global and nodal network metrics were calculated for statistical analyses. Small-world properties were exhibited by pediatric patients after brain surgery and by healthy controls. After brain surgery, pediatric patients with epilepsy exhibited a higher shortest path length, lower global efficiency, and higher nodal efficiency in the cuneus than those in healthy controls. These results revealed that pediatric epilepsy after brain surgery, even with normal functions, showed altered topological organization of the individual SCNs, which revealed residual network topological abnormalities and may provide initial evidence for the underlying functional impairments in the brain of pediatric patients with epilepsy after surgery that can occur in the future.

UNASSIGNED: Rural living adults have higher rates of obesity compared with their urban counterparts and less access to weight management programs. Previous research studies have demonstrated clinically relevant weight loss in rural living adults who complete weight management programs delivered by university affiliated interventionists. However, this approach limits the potential reach, adoption, implementation, and maintenance of weight management programs for rural residents. Weight management delivered through rural health clinics by non-physician clinic associated staff, for example, nurses, registered dieticians, allied health professionals, etc. has the potential to improve access to weight management for rural living adults. This trial compared the effectiveness of a 6-month multicomponent weight management intervention for rural living adults delivered using group phone calls (GP), individual phone calls (IP) or an enhanced usual care control (EUC) by rural clinic associated staff trained by our research team.
UNASSIGNED: Rural living adults with overweight/obesity (n = 187, age ∼ 50 years 82% female, body mass index ∼35 kg/m2) were randomized (2:2:1) to 1 of 3 intervention arms: GP, which included weekly ∼ 45 min sessions with 7-14 participants (n = 71), IP, which included weekly ∼ 15 min individual sessions (n = 80), or EUC, which included one-45 min in-person session at baseline.
UNASSIGNED: Weight loss at 6 months was clinically relevant, that is, ≥5% in the GP (-11.4 kg, 11.7%) and the IP arms (-9.1 kg, 9.2%) but not in the EUC arm (-2.6%, -2.5% kg). Specifically, 6 month weight loss was significantly greater in the IP versus EUC arms (-6.5 kg. p ≤ 0.025) but did not differ between the GP and IP arms (-2.4 kg, p > 0.025). The per participant cost per kg. weight loss for implementing the intervention was $93 and $60 for the IP and GP arms, respectively.
UNASSIGNED: Weight management delivered by interventionists associated with rural health clinics using both group and IP calls results in clinically relevant 6 months weight loss in rural dwelling adults with overweight/obesity with the group format offering the most cost-effective strategy. Clinical trial registration: ClinicalTrials.gov (NCT02932748).

Many animals and plants have species-typical annual cycles, but individuals vary in their timing of life-history events. Individual variation in fur replacement (moult) timing is poorly understood in mammals due to the challenge of repeated observations and longitudinal sampling. We examined factors that influence variation in moult duration and timing among elephant seals (Mirounga angustirostris). We quantified the onset and progression of fur loss in 1178 individuals. We found that an exceptionally rapid visible moult (7 days, the shortest of any mammals or birds), and a wide range of moult start dates (spanning 6-10× the event duration) facilitated high asynchrony across individuals (only 20% of individuals in the population moulting at the same time). Some of the variation was due to reproductive state, as reproductively mature females that skipped a breeding season moulted a week earlier than reproductive females. Moreover, individual variation in timing and duration within age-sex categories far outweighed (76-80%) variation among age-sex categories. Individuals arriving at the end of the moult season spent 50% less time on the beach, which allowed them to catch up in their annual cycles and reduce population-level variance during breeding. These findings underscore the importance of individual variation in annual cycles.

In the context of a health crisis of unprecedented magnitude that we have experienced such as COVID-19 we join the efforts of practitioners and researchers to answer the question: \'What is the organizational context that promotes individual adaptation in a context of adversity?\'. Specifically, our research aims to explore organizational practices that promote individual resilience in a COVID-19 crisis situation and in a Tunisian context. Therefore, we believe that the paradigm (resilience in the face of the COVID-19 crisis) and the context (Tunisian) both constitute the originality of our article. Our research contribution consists in demonstrating that the company has a managerial need to strengthen the psychological protective factors of its employees, which will promote their individual resilience in the organization. This necessarily leads it to develop the individual\'s defense mechanisms against trauma, psychological reconstruction and post-resilience learning. This modeling of resilience allowed us to observe and recognize it in sixteen Tunisian companies by using a qualitative study based on sixteen semi-structured interviews analyzed by the \'Nvivo 12\' software in order to explore the functioning of individual resilience in a real organizational context.