近几十年来,离子液体(IL)因其值得注意的性质而引起了研究兴趣,如热稳定性,低或无可燃性,和可忽略的蒸汽压。此外,它们的可调性为设计具有适用于许多工业领域应用的属性的IL提供了无限的机会。本研究旨在合成两个系列的甲基咪唑ILS,它们的阳离子(C9,C10,C12,C14,C16,C18,C20)带有长烷基链,并具有四氟硼酸根(BF4)和1,3-二甲基-5-磺基间苯二甲酸(DMSIP)作为抗衡离子。使用1H-NMR和MALDI-TOF表征IL,并通过DSC和TGA研究了它们的热行为。此外,抗菌剂,抗癌,并分析了IL的细胞毒性活性。此外,最有前途的IL被以不同的浓度(0.5,1,5重量%)掺入聚氯乙烯(PVC)通过溶剂流延获得抗微生物共混膜。所得PVC/IL薄膜的热性能和稳定性,以及它们的疏水性/亲水性,IL表面分布,和释放,使用DSC和TGA进行了研究,接触角(CA),SEM,和紫外-可见光谱法,分别。此外,分析了共混物的抗微生物和细胞毒性。体外结果表明,纯IL对单核细胞增生李斯特菌具有抗菌和抗肿瘤活性,大肠杆菌,荧光假单胞菌菌株,和乳腺癌细胞系(MCF7),分别,主要取决于它们的结构。这些活性在包含BF4阴离子的系列中更高,并且随着甲基咪唑鎓阳离子烷基链长度的增加而增加。然而,烷基链延伸超过C16会导致抗菌活性降低,表示截止效果。在体外生物相容性方面也观察到类似的趋势。将这两个系列的IL加载到PVC基质中不影响PVC共混物膜的热稳定性。然而,它们的Tonset随着IL浓度和烷基链长度的增加而降低。同样,随着IL浓度和烷基链的增加,这两个系列的PVC/IL膜都变得更加亲水。在5%浓度下加载IL导致在共混膜表面上显著的IL积累(如在SEM图像中观察到的),随后,更高的释放。与健康人真皮成纤维细胞(HDF)细胞的生物相容性评估和抗肿瘤特性的研究揭示了有希望的药理学特征。这些发现为IL在生物医学应用中的潜在利用提供了强有力的支持。特别是在癌症治疗的背景下,作为抗菌剂,以应对抗生素耐药性的挑战。此外,PVC/IL薄膜的独特性能使其成为推进医疗保健技术的多功能材料,从药物递送到组织工程和抗菌涂层到诊断设备。
In recent decades, ionic liquids (ILs) have garnered research interest for their noteworthy properties, such as thermal stability, low or no flammability, and negligible vapour pressure. Moreover, their tunability offers limitless opportunities to design ILs with properties suitable for applications in many industrial fields. This study aims to synthetise two series of methylimidazolium ILs bearing long alkyl chain in their cations (C9, C10, C12, C14, C16, C18, C20) and with tetrafluoroborate (BF4) and the 1,3-dimethyl-5-sulfoisophthalate (DMSIP) as counter ions. The ILs were characterised using 1H-NMR and MALDI-TOF, and their thermal behaviour was investigated through DSC and TGA. Additionally, the antimicrobial, anticancer, and cytotoxic activities of the ILs were analysed. Moreover, the most promising ILs were incorporated at different concentrations (0.5, 1, 5 wt%) into polyvinyl chloride (PVC) by solvent casting to obtain antimicrobial blend films. The thermal properties and stability of the resulting PVC/IL films, along with their hydrophobicity/hydrophilicity, IL surface distribution, and release, were studied using DSC and TGA, contact angle (CA), SEM, and UV-vis spectrometry, respectively. Furthermore, the antimicrobial and cytotoxic properties of blends were analysed. The in vitro results demonstrated that the antimicrobial and antitumor activities of pure ILs against t Listeria monocytogenes, Escherichia coli, Pseudomonas fluorescens strains, and the breast cancer cell line (MCF7), respectively, were mainly dependent on their structure. These activities were higher in the series containing the BF4 anion and increased with the increase in the methylimidazolium cation alkyl chain length. However, the elongation of the alkyl chain beyond C16 induced a decrease in antimicrobial activity, indicating a cut-off effect. A similar trend was also observed in terms of in vitro biocompatibility. The loading of both the series of ILs into the PVC matrix did not affect the thermal stability of PVC blend films. However, their Tonset decreased with increased IL concentration and alkyl chain length. Similarly, both the series of PVC/IL films became more hydrophilic with increasing IL concentration and alkyl chain. The loading of ILs at 5% concentration led to considerable IL accumulation on the blend film surfaces (as observed in SEM images) and, subsequently, their higher release. The biocompatibility assessment with healthy human dermal fibroblast (HDF) cells and the investigation of antitumoral properties unveiled promising pharmacological characteristics. These findings provide strong support for the potential utilisation of ILs in biomedical applications, especially in the context of cancer therapy and as antibacterial agents to address the challenge of antibiotic resistance. Furthermore, the unique properties of the PVC/IL films make them versatile materials for advancing healthcare technologies, from drug delivery to tissue engineering and antimicrobial coatings to diagnostic devices.