作为一种疾病,利什曼病在全球范围内被忽视的热带疾病和被忽视的贫困感染中仍然是一个不断的挑战。目前,对抗利什曼原虫热带感染的诊断和治疗不是实质性的补救措施,需要先进和具体的研究。因此,需要一种潜在的新靶点来克服已确定的药物模式在致病性方面的局限性.在这次审查中,我们在利什曼原虫核孔复合物的核孔中提出了一些从头算的发现。关于其他传染性原生生物。所以,通过结构分析和动力学研究,我们假设核孔分子机制和功能。看门人午睡,mRNA的输出,有丝分裂纺锤体的形成是细胞力学的显着特征,这受到动态核孔蛋白的调节。这里,各种研究表明,利什曼原虫物种的Nup93/NIC96,Nup155/Nup144,Mlp1/Mlp2/Tpr可以作为诊断标记,免疫调节,和新的药物靶标。核孔蛋白功能相互作用剂如NUP54/57,RNA解旋酶,泛素蛋白连接酶,外运1,推定的T淋巴细胞触发因子,和9个未表征的蛋白质表明很少有更高的目标。靶向利什曼原虫进口/出口的新药。并确定了Leptomycin-B的作用机制,正弦化合物,姜黄素,Selinexor可以是治疗学中的弧光。利什曼原虫核孔蛋白综述的实质是将我们的研究重新集中在热带疗法的崇高分子靶标上。
UNASSIGNED:在线版本包含补充材料,可在10.1007/s12639-022-01515-0获得。
As an ailment, leishmaniasis is still an incessant challenge in neglected tropical diseases and neglected infections of poverty worldwide. At present, the diagnosis and treatment to combat Leishmania tropical infections are not substantial remedies and require advanced & specific research. Therefore, there is a need for a potential novel target to overcome established medicament modalities\' limitations in pathogenicity. In this review, we proposed a few ab initio findings in nucleoporins of nuclear pore complex in Leishmania sp. concerning other infectious protists. So, through structural analysis and dynamics studies, we hypothesize the nuclear pore molecular machinery & functionality. The gatekeepers Nups, export of mRNA, mitotic spindle formation are salient features in cellular mechanics and this is regulated by dynamic nucleoporins. Here, diverse studies suggest that Nup93/NIC96, Nup155/Nup144, Mlp1/Mlp2/Tpr of Leishmania Species can be a picked out marker for diagnostic, immune-modulation, and novel drug targets. In silico prediction of nucleoporin-functional interactors such as NUP54/57, RNA helicase, Ubiquitin-protein ligase, Exportin 1, putative T-lymphocyte triggering factor, and 9 uncharacterized proteins suggest few more noble targets. The novel drug targeting to importins/exportins of Leishmania sp. and defining mechanism of Leptomycin-B, SINE compounds, Curcumins, Selinexor can be an arc-light in therapeutics. The essence of the review in Leishmania\'s nucleoporins is to refocus our research on noble molecular targets for tropical therapeutics.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s12639-022-01515-0.