■Fontan程序,治疗单心室缺损儿童的标准手术缓解方法,由于在腔肺交界处缺乏泵送,多年来导致全身性并发症。因此考虑了专门为腔肺支持开发的设备,虽然目前商用心室辅助装置(VAD)对血液产生高剪切率,并且有儿科适用性的问题。
■为了证明小型,无阀,非侵入性的血液和脉动旋转泵,集成了阻抗和蠕动效应。
■原型泵是在内部设计和制造的,没有任何努力来优化其规格。然后在体外测试,就抽运频率的影响而言,背景压差和泵尺寸对输出性能的影响。
■净流速(NFR)和最大压头输送均在正常生理范围内合理地线性取决于泵送频率。在NFR和不对称泵浦的程度之间也观察到正线性。该装置将NFR调节在有利的压头差,并克服显著的不利压头差。此外,性能显示对设备尺寸不敏感。
■证明了集成阻抗和蠕动效应的新型旋转泵在正常生理条件下的可行性,而无需任何优化工作。它为未来可能的儿科腔肺支持提供了有希望的结果,并需要进一步研究小型化和可能的溶血。
UNASSIGNED: Fontan procedure, the standard surgical palliation to treat children with single ventricular defects, causes systemic complications over years due to lack of pumping at cavopulmonary junction. A device developed specifically for cavopulmonary support is thus considered, while current commercial ventricular assist devices (VAD) induce high shear rates to blood, and have issues with paediatric suitability.
UNASSIGNED: To demonstrate the feasibility of a small, valveless, non-invasive to blood and pulsatile rotary pump, which integrates
impedance and peristaltic effects.
UNASSIGNED: A prototype pump was designed and fabricated in-house without any effort to optimise its specification. It was then tested in vitro, in terms of effect of pumping frequency, background pressure differences and pump size on output performance.
UNASSIGNED: Net flow rate (NFR) and maximum pressure head delivery are both reasonably linearly dependent on pumping frequency within normal physiological range. Positive linearity is also observed between NFR and the extent of asymmetric pumping. The device regulates NFR in favourable pressure head difference and overcomes significant adverse pressure head difference. Additionally, performance is shown to be insensitive to device size.
UNASSIGNED: The feasibility of the novel rotary pump integrating
impedance and peristaltic effects is demonstrated to perform in normal physiological conditions without any optimisation effort. It provides promising results for possible future paediatric cavopulmonary support and warrants further investigation of miniaturisation and possible haemolysis.