■额颞叶变性(FTLD)与尸检中发现的tau(FTLD-tau)或TDP(FTLD-TDP)包涵体有关。动脉自旋标记(ASL)MRI通常与结构T1加权图像(T1w)在同一会话中获得,能够检测脑血流量(CBF)的区域变化。我们假设使用基于边界的配准(BBR)进行更多自由度的ASL-T1w配准将更好地对齐ASL和T1w图像,并且与患者参与者的手动配准相比,对区域灌注不足差异的敏感性更高。我们假设灌注不足将与疾病严重程度的临床测量相关,FTLD改良的临床痴呆评定量表(FTLD-CDR)。
■散发性可能FTLD-tau(sFTLD-tau;N=21)患者,偶发性可能FTLD-TDP(sFTLD-TDP;N=14),和对照组(N=50)从家族性和散发性额颞叶变性连接组学成像项目(FTDHCP)招募。皮尔逊的相关系数(CC)计算在皮层顶点的CBF每个参与者之间的3种注册方法:(1)手动注册,(2)手动注册初始化BBR(手动+BBR),(3)和BBR初始化采用FLIRT(FLIRT+BBR)。在图像对准之后,对于每种配准方法,在相同的感兴趣区域(ROI)中计算平均CBF。进行每种配准方法的CC值的配对t检验以比较比对。使用t检验比较各组间每个ROI的平均CBF。在p<0.05(Bonferroni校正)时,差异被认为是显著的。我们进行了线性回归,将FTLD-CDR与sFTLD-tau和sFTLD-TDP患者的平均CBF相关联,单独(p<0.05,未校正)。
■所有配准方法均表明,相对于对照组,每个患者组在额叶和颞叶区域的灌注明显不足。所有配准方法都检测到左岛叶皮质灌注不足,颞中回,sFTLD-TDP相对于sFTLD-tau的颞极。在sFTLD-TDP中,FTLD-CDR与右颞和眶额ROI的CBF呈负相关。手动+BBR类似于FLIRT+BBR进行。
■与对照组相比,ASL对患者参与者不同的灌注不足区域敏感,在sFTLD-TDP相对于sFTLD-tau的患者中,灌注的减少与疾病严重程度的增加有关,至少在sFTLD-TDP.BBR可以为对照组和患者充分注册ASL-T1w图像。
UNASSIGNED: Frontotemporal lobar degeneration (FTLD) is associated with FTLD due to tau (FTLD-tau) or TDP (FTLD-TDP) inclusions found at autopsy. Arterial Spin Labeling (ASL) MRI is often acquired in the same session as a structural T1-weighted image (T1w), enabling detection of regional changes in cerebral blood flow (CBF). We hypothesize that ASL-T1w registration with more degrees of freedom using boundary-based registration (BBR) will better align ASL and T1w images and show increased sensitivity to regional hypoperfusion differences compared to manual registration in patient participants. We hypothesize that hypoperfusion will be associated with a clinical measure of disease severity, the FTLD-modified clinical dementia rating scale sum-of-boxes (FTLD-CDR).
UNASSIGNED: Patients with sporadic likely FTLD-tau (sFTLD-tau; N = 21), with sporadic likely FTLD-TDP (sFTLD-TDP; N = 14), and controls (N = 50) were recruited from the Connectomic Imaging in Familial and Sporadic Frontotemporal Degeneration project (FTDHCP). Pearson\'s Correlation Coefficients (CC) were calculated on cortical vertex-wise CBF between each participant for each of 3 registration methods: (1) manual registration, (2) BBR initialized with manual registration (manual+BBR), (3) and BBR initialized using FLIRT (FLIRT+BBR). Mean CBF was calculated in the same regions of interest (ROIs) for each registration method after image alignment. Paired t-tests of CC values for each registration method were performed to compare alignment. Mean CBF in each ROI was compared between groups using t-tests. Differences were considered significant at p < 0.05 (Bonferroni-corrected). We performed linear regression to relate FTLD-CDR to mean CBF in patients with sFTLD-tau and sFTLD-TDP, separately (p < 0.05, uncorrected).
UNASSIGNED: All registration methods demonstrated significant hypoperfusion in frontal and temporal regions in each patient group relative to controls. All registration methods detected hypoperfusion in the left insular cortex, middle temporal gyrus, and temporal pole in sFTLD-TDP relative to sFTLD-tau. FTLD-CDR had an inverse association with CBF in right temporal and orbitofrontal ROIs in sFTLD-TDP. Manual+BBR performed similarly to FLIRT+BBR.
UNASSIGNED: ASL is sensitive to distinct regions of hypoperfusion in patient participants relative to controls, and in patients with sFTLD-TDP relative to sFTLD-tau, and decreasing perfusion is associated with increasing disease severity, at least in sFTLD-TDP. BBR can register ASL-T1w images adequately for controls and patients.