■物质使用和睡眠问题在精神病患者中很常见,但他们在这些患者中的关联尚未得到评估。我们的目的是在全国范围内大规模的精神病患者队列中调查物质使用与睡眠问题之间的关系。
■这项研究是芬兰SUPER研究的一部分,属于斯坦利全球神经精神基因组学计划。在这个横截面中,多中心研究,参与者(N=8616)从初级卫生保健和专科卫生保健中招募.精神分裂症患者,分裂情感障碍,双相情感障碍,包括精神病性抑郁症。关于当前酒精(酒精使用障碍识别测试-简明)和香烟使用以及终身非法药物使用的信息,包括大麻,苯二氮卓类药物,安非他明,和阿片类药物,是用问卷收集的。我们的logistic回归分析的睡眠结果是短(≤6小时)和长睡眠(≥10小时)持续时间,开始入睡的困难,清晨醒来,疲劳,睡眠质量(SQ)差。
■自我报告的物质使用与更高的睡眠问题患病率相关。随着年龄的调整,性别,诊断组,和生活状态,有害酒精使用(例如,差的SQ优势比[OR]=1.80,95%CI:1.49至2.16,P<.001),当前吸烟(短睡眠时间OR=1.28,95%CI:1.08至1.52,P=0.005),和终生误用苯二氮卓类药物(启动睡眠困难OR=2.00,95%CI:1.55至2.48,P<.001)与睡眠问题有关。
■物质使用与睡眠问题有关。我们的发现强调了在治疗精神病患者的睡眠问题时使用筛查物质的潜在益处。
UNASSIGNED: Substance use and sleep problems are common in patients with psychotic disorders, but their associations in these patients have not been evaluated. We aimed to investigate associations between substance use and sleep problems in a large nationwide cohort of patients with a psychotic disorder.
UNASSIGNED: This study is part of the Finnish SUPER study, which belongs to the Stanley Global Neuropsychiatric Genomics Initiative. In this cross-sectional, multicenter study, participants (N = 8616) were recruited from primary and specialized healthcare. Patients with schizophrenia, schizoaffective disorder, bipolar disorder, and psychotic depression were included. Information on current alcohol (Alcohol Use Disorders Identification Test-Concise) and cigarette use as well as on lifetime illicit drug use, including cannabis, benzodiazepines, amphetamines, and opioids, was collected using questionnaires. The sleep outcomes in our logistic regression analysis were short (≤6 h) and long sleep (≥10 h) duration, difficulties initiating asleep, early morning awakenings, fatigue, and poor sleep quality (SQ).
UNASSIGNED: Self-reported substance use was associated with a higher prevalence of sleep problems. After adjustments with age, gender, diagnostic group, and living status, hazardous alcohol use (eg, poor SQ odds ratio [OR] = 1.80, 95% CI: 1.49 to 2.16, P < .001), current smoking (short sleep duration OR = 1.28, 95% CI: 1.08 to 1.52, P = .005), and lifetime benzodiazepine misuse (difficulties initiating sleep OR = 2.00, 95% CI: 1.55 to 2.48, P < .001) were associated with sleep problems.
UNASSIGNED: Substance use was associated with sleep problems. Our findings underline the potential benefits of screening substance use when treating sleep problems in patients with psychotic disorders.