目的：评估宫腔输注和宫腔镜下注射自体富血小板血浆（PRP）对持续薄型子宫内膜（EM）患者进行整倍体冷冻胚胎移植（EFET）周期的影响。方法：这项前瞻性病例对照研究纳入了116名患有薄EM（<7mm）的不孕妇女，她们接受了激素替代疗法（HRT）进行EFET。这些女性至少经历过一次不成功的EFET周期，这导致了周期的取消或妊娠失败。共有55名妇女在FET前接受了PRP宫内输注,38人接受了宫腔镜注射PRP，23例接受无PRP的标准HRT治疗(对照组)。在这些周期中仅转移整倍体胚胎。主要结局是EFET后的植入率（IR）和临床妊娠率（CPR）。结果：在接受宫腔灌注和宫腔镜下注射PRP后，78.2%和55.3%的患者，分别,显示EM厚度超过7毫米，其次是胚胎移植。宫腔镜注射组的IR显著增高（52%），CPR的趋势更高（52％），活产率(38%)高于对照组(18%,22%,和4%）。结论:宫腔灌注和宫腔镜下注射自体PRP可能是增加HRT周期EM厚度的有效方法。根据我们的结果,这两种方法都可以增加EM厚度，虽然宫腔镜注射似乎在增加IR方面提供了更显著的帮助，CPR,持续性薄EM患者EFET后的活产率。
Objectives: To evaluate the effect of intrauterine infusion and hysteroscopic injection of autologous platelet-rich plasma (PRP) in patients with a persistent thin endometrium (EM) undergoing euploid frozen embryo transfer (EFET) cycles. Methods: This prospective case-control study enrolled 116 infertile women with thin EM (<7 mm) who underwent hormone replacement therapy (HRT) for EFET. These women had experienced at least one previous unsuccessful EFET cycle, which either resulted in the cancellation of the cycle or failure of pregnancy. A total of 55 women received an intrauterine infusion of PRP before FET, 38 received a hysteroscopic injection of PRP, and 23 received standard HRT treatment without PRP (control group). Only euploid embryos were transferred in these cycles. The primary outcomes were the implantation rate (IR) and clinical pregnancy rate (CPR) after EFET. Results: After receiving intrauterine infusion and hysteroscopic injection of PRP, 78.2% and 55.3% of patients, respectively, showed an EM thickness exceeding 7 mm, followed by embryo transfer. The hysteroscopic injection group demonstrated significantly higher IR (52%), a higher trend of CPR (52%), and a higher live birth rate (38%) than the control group (18%, 22%, and 4%). Conclusions: Intrauterine infusion and hysteroscopic injection of autologous PRP may be effective methods to increase EM thickness in HRT cycles. According to our results, both methods could increase EM thickness, while hysteroscopic injection appeared to provide more significant assistance in increasing IR, CPR, and live birth rate after EFET in patients with persistent thin EM.
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