本研究的目的是探讨妊娠早期甲状腺功能减退症与小肠细菌过度生长(SIBO)之间的关系以及益生菌的作用。将妊娠早期甲状腺功能减退患者和同期正常孕妇纳入甲烷-氢呼气试验,比较SIBO的发生率,平滑曲线拟合,和临床症状的差异。对于那些与SIBO结合的人,临床症状转换率,甲状腺激素,在常规左甲状腺素钠片的基础上,比较益生菌治疗21天后相关炎症指标的变化。结果如下:(1)妊娠合并甲状腺功能减退症患者合并SIBO的发生率为56.0%,显著高于同期正常孕妇的28.0%。(2)妊娠期甲减患者90min氢气加甲烷气体最高值与FT4呈显著负相关(p<.001,SD=0.169)。(3)合并SIBO后,两组腹胀症状均显著增加(p=0.036,p=0.025),治疗后转化率分别为69.2%和75.0%,分别。(4)甲状腺功能减退症,妊娠合并SIBO,TSH,治疗前CRP较高(p=.001,p=.012),治疗后CRP明显下降(p=.001,p=.008)。妊娠早期甲状腺功能减退与SIBO有关,和益生菌治疗是显著有效的。
The aim of this study was to investigate the association between hypothyroidism in early pregnancy and small intestinal bacterial overgrowth (SIBO) and the effect of probiotics. Patients with hypothyroidism in early pregnancy and normal pregnant women during the same period were included in the methane-hydrogen breath test to compare the incidence of SIBO, smoothed curve fit, and differences in clinical symptoms. For those who combined with SIBO, the rate of clinical symptom conversion, thyroid hormones, and changes in associated inflammatory indexes were compared after 21 days of treatment with probiotics on top of conventional levothyroxine sodium tablets. The results are as follows: (1) The incidence of combined SIBO in patients with hypothyroidism in pregnancy was 56.0%, significantly higher than the 28.0% of normal pregnant women during the same period. (2) The highest value of hydrogen plus methane gas in 90 min in pregnancy hypothyroid patients showed a significant negative correlation with FT4 (p < .001, SD = 0.169). (3) Abdominal distension symptoms were significantly increased in both groups after combined SIBO (p = .036, p = .025), and the conversion rate after treatment was 69.2% and 75.0%, respectively. (4) In hypothyroidism, pregnancy combined with SIBO, TSH, and CRP was higher before treatment (p = .001, p = .012) and decreased significantly after treatment (p = .001, p = .008). Hypothyroidism in early pregnancy is associated with SIBO, and probiotic treatment is significantly effective.