背景:非高密度脂蛋白胆固醇(non-HDL-C)水平可增加甲状腺功能减退患者的心脏代谢危险因素,但各项研究的结果并不一致。这项研究的目的是发现甲状腺功能减退症患者的非HDL-C与心脏代谢危险因素之间的关联。
方法:在本病例对照研究中,共纳入120名受试者,其中60名诊断为甲状腺功能减退的患者和60名年龄匹配的健康对照者,30-65岁。身体质量指数(BMI),腰围(WC),测量收缩压和舒张压(SBP和DBP)。促甲状腺激素(TSH),三碘甲状腺原氨酸(T3),甲状腺素(T4),空腹血糖(FBS),总胆固醇(TC),甘油三酯(TG),并估计高密度脂蛋白胆固醇(HDL-C)。低密度脂蛋白胆固醇(LDL-C),极低密度脂蛋白胆固醇(VLDL-C),计算非HDL-C。P值<0.05被认为是统计学上显著的。
结果:BMI平均值,WC,FBS,TSH,TC,TG,非HDL-C,LDL-C,VLDL-C,SBP,与对照组相比,DBP和DBP显著升高(p<0.001)。然而,与对照组相比,T3,T4和HDL-C的平均值显著降低(p<0.001).Non-HDL-C与年龄呈显著正相关(r=0.345,p<0.01),TC(r=0.451,p<0.01),TG(r=0.269,p<0.05),LDL-C(r=0.402,p<0.01),和VLDL-C(r=0.269,p<0.05)。然而,non-HDL-C与HDL-C呈显著负相关(r=-0.330,p<0.05)。非HDL-C可显著预测甲状腺功能减退症患者的心脏代谢风险(F(13,46)=3.500,p<0.001)。
结论:Non-HDL-C与甲状腺功能减退患者的年龄和血脂异常显著相关。Non-HDL-C可显著预测甲状腺功能减退症患者的心脏代谢危险因素。
BACKGROUND: Non-high-density lipoprotein cholesterol (non-HDL-C) levels can increase the cardiometabolic risk factors in patients with hypothyroidism, but the findings across studies have not been consistently conclusive. The aim of this study was to find the association between non-HDL-C and cardiometabolic risk factors in patients with hypothyroidism.
METHODS: In this case-control study, a total of 120 subjects among which 60 diagnosed hypothyroidism patients and 60 age-matched healthy controls were enrolled, aged 30-65 years. Body mass index (BMI), waist circumference (WC), and systolic and diastolic blood pressures (SBP and DBP) were measured. Thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), fasting blood sugar (FBS), total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) were estimated. Low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and non-HDL-C were calculated. A p-value of <0.05 was considered statistically significant.
RESULTS: Mean of BMI, WC, FBS, TSH, TC, TG, non-HDL-C, LDL-C, VLDL-C, SBP, and DBP were significantly elevated in cases compared to controls (p<0.001). However, the mean of T3, T4, and HDL-C were significantly reduced in cases compared to controls (p<0.001). Non-HDL-C has shown a significant positive correlation with age (r=0.345, p<0.01), TC (r=0.451, p<0.01), TG (r=0.269, p<0.05), LDL-C (r=0.402, p<0.01), and VLDL-C (r=0.269, p<0.05) among cases. However, non-HDL-C has shown a significant negative correlation with HDL-C (r=-0.330, p<0.05) among cases. Non-HDL-C significantly predicted cardiometabolic risk in patients with hypothyroidism (F(13,46)=3.500, p<0.001).
CONCLUSIONS: Non-HDL-C has shown a significant association with age and lipid abnormalities in patients with hypothyroidism. Non-HDL-C significantly predicts cardiometabolic risk factors in patients with hypothyroidism.