介绍鼻-鼻窦炎的内窥镜鼻窦手术,先发制人的α2激动剂可乐定已被用于减少交感神经输出,降低血压,从而降低手术出血。这项研究的目的是分析口服可乐定术前用药对功能性内窥镜鼻窦手术患者的影响。方法这项研究于2020年12月至2022年11月在两组30名患者中进行:可乐定(200μgm口服)和安慰剂。参数记录在基线,服用药物后60分钟,在感应时,五分钟时,10、20、30、45、60、75、105和120。研究了出血的六点平均类别量表。IBMSPSSStatisticsforWindows,版本20.0(2011年发布;IBMCorp.,Armonk,纽约,美国)用于统计分析,并且p<0.05被认为是显著的。结果人口统计标准无统计学意义。心率(HR)和平均动脉压(MAP)在基线和第120分钟标记处无统计学意义,并在其他时间间隔显著。可乐定组失血分级较少,差异有统计学意义(P<0.001)。结论在诱导前60分钟先发制人口服可乐定200mcg可通过控制血流动力学减少手术出血。
Introduction For endoscopic sinus surgery for rhinosinusitis, pre-emptive Alpha 2 agonist clonidine has been used to reduce sympathetic output, which lowers blood pressure and consequently surgical bleeding. The aim of this study was to analyze the effects of oral clonidine premedication in patients undergoing functional endoscopic sinus surgery. Methods This study was performed between December 2020 to November 2022 among two groups of 30 patients each: clonidine (200 μgm oral) and placebo. Parameters were recorded at baseline, 60 mins after administering the drugs, at induction, and at minutes five, 10, 20, 30, 45, 60, 75, 105, and 120. Six-point average category scale for bleeding was studied. IBM SPSS Statistics for Windows, Version 20.0 (Released 2011; IBM Corp., Armonk, New York, United States) was used for statistical analysis, and p < 0.05 was considered significant. Results Demographic criteria were statistically non-significant. Heart rate (HR) and mean arterial pressure (MAP) were statistically non-significant at baseline and the 120th min mark, and were significant at other time intervals. The blood loss grading was less in the clonidine group, and the difference was found to be statistically significant (P < 0.001). Conclusion Pre-emptive oral clonidine 200 mcg 60 min prior to induction was found to reduce surgical bleeding by controlling haemodynamics.