背景:动脉高血压是一种影响约35%世界人口的全身性疾病。用于其控制的药物可产生唾液分泌不足。这项工作评估了光生物调节对唾液流速的影响,唾液pH值,总蛋白质浓度,使用抗高血压药物的个体的钙浓度。
方法:41名受试者随机分为两组:对照组(安慰剂)和光生物调节组。受试者的唾液腺(20个部位)用808nm的激光照射,4J/site每周一次,持续4周,并在整个治疗前后测量其唾液流量。
结果:组内分析(治疗前和治疗后)显示,在光生物调节组中,未刺激和刺激的唾液流存在显着差异(分别为p=0.0007和p=0.0001)。比较安慰剂和光生物调节组,治疗后未刺激(p=0.0441)和刺激唾液流量(p=0.0441)均存在显著差异.在pH值上没有发现显著差异,总蛋白质浓度,钙浓度。
结论:尽管使用了影响神经系统并通常导致唾液分泌减少的药物,光生物调节显示出显着的将唾液产生提高75%的能力。
BACKGROUND: Arterial hypertension is a systemic condition that affects about 35% of the world population. The drugs that are used for its control can produce
hyposalivation. This work evaluated the effect of photobiomodulation on salivary flow rate, salivary pH, total protein concentration, and calcium concentration in individuals using antihypertensive medications.
METHODS: 41 subjects were randomly allocated in one of two groups: control (placebo) and photobiomodulation. The subjects had their salivary glands (20 sites) irradiated with a laser emitting at 808 nm, 4J/site once a week for 4 weeks and had their salivary flow measured before and after the whole treatment.
RESULTS: The intragroup analysis (before and after treatment) shows a significant difference for both non-stimulated and stimulated salivary flow in the photobiomodulation group (p = 0.0007 and p = 0.0001, respectively). Comparing the placebo with the photobiomodulation group, significant differences were found for both non-stimulated (p = 0.0441) and stimulated salivary flow (p = 0.0441) after the treatment. No significant differences were found in pH, total protein concentration, calcium concentration.
CONCLUSIONS: Despite the usage of drugs that influence the nervous system and typically result in a reduction of saliva production, photobiomodulation demonstrated a remarkable ability to enhance saliva production by a significant 75%.