■头颈癌(HNC)是一种复杂的疾病,多种风险因素可能导致其进展。观察性研究表明,单纯疱疹病毒(HSV)可能与HNC的风险有关。然而,它们之间的因果效应和方向尚不清楚.
■本研究基于最新的公共卫生数据和全基因组关联研究(GWAS)数据,采用孟德尔随机化(MR)方法对HSV感染与头颈癌之间的因果关系进行评估。因果关系是使用IVW估计的,加权中位数,还有MR-Egger.随后进行反向MR分析。CochransQ测试,MR-Egger截距测试,留下一个分析,漏斗图全部用于敏感性分析。
■遗传预测的较高水平的HSV-1IgG与HNC(OR=1.0019,95CI=1.0003-1.0036,p=0.0186,IVW)和口腔和口咽癌(OR=1.0018,95CI=1.0004-1.0033,p=0.0105,IVW)有因果关系。反向MR分析未证明HSV和HNC之间存在反向因果关系。然而,HSV-2感染与HNC数据和口鼻咽癌数据无因果关系。进行了敏感性分析,发现没有异质性和水平多效性。
■集体,HSV感染与HNC风险增加之间存在显著关联,为这种恶性肿瘤的病因提供有价值的见解。需要进一步深入研究来验证这些发现并阐明其基础机制。
UNASSIGNED: Head and neck cancer (HNC) is a complex disease, and multiple risk factors can lead to its progression. Observational studies indicated that herpes simplex virus (
HSV) may be correlated with the risk of HNC. However, the causal effects and direction between them were still unclear.
UNASSIGNED: This study utilized a Mendelian randomization (MR) approach for causality assessment between
HSV infection and Head and neck cancer based on the latest public health data and Genome-Wide Association Study (GWAS) data. The causal effects were estimated using IVW, weighted median, and MR-Egger. A reverse MR analysis was subsequently performed. Cochrans Q test, MR-Egger intercept test, leave one out analysis, and the funnel plot were all used in sensitivity analyses.
UNASSIGNED: Genetically predicted higher level of
HSV-1 IgG was causally related to HNC (OR=1.0019, 95%CI=1.0003-1.0036, p=0.0186, IVW) and oral and oropharyngeal cancer (OR=1.0018, 95%CI=1.0004-1.0033, p=0.0105, IVW). The reverse MR analysis did not demonstrate a reverse causal relationship between
HSV and HNC. However,
HSV-2 infection was not causally related to HNC data and oropharyngeal cancer data. Sensitivity analysis was performed and revealed no heterogeneity and horizontal pleiotropy.
UNASSIGNED: Collectively, a significant association was noted between HSV infection and increased risk of HNC, providing valuable insights into the etiology of this malignancy. Further in-depth study is needed to validate these findings and elucidate the underpinning mechanisms.