背景:男性乳腺癌占所有乳腺癌的1%。它的低频率导致缺乏意识,导致严重的诊断延迟。此外,这限制了现有的证据,主要使用基于女性的诊断-治疗算法。
目的:分析患病率,临床表现,解剖学和病理学特征,和男性乳腺癌的预后使用最大的系列之一。其次,将我们的数据与在女性中进行的研究进行比较。
方法:多中心,观察,描述性,描述性在阿拉贡自治社区进行了回顾性研究,西班牙,从1995年到2022年,包括病理诊断为乳腺癌的男性。
结果:共纳入148例患者,患病率为1%。最常见的临床表现是可触及的乳晕后肿块。浸润性导管癌是最常见的类型(88.89%),管腔B是主要亚型(47.76%)。手术是最常用的治疗方法;乳房切除术占90.34%,AL占46.89%。诊断时,52.46%有乳房外受累。复发率为24.1%,归因于该疾病的死亡率为14.6%。
结论:诊断时转移受累率很高,残害手术的比例很高,与现有的男性研究相比,复发次数很多。此外,与女性乳腺癌相比,预后较差,尽管这些肿瘤具有较低侵袭性的分子亚型。这些发现强调了进行针对男性的研究以制定特定协议的重要性。
BACKGROUND: Male breast cancer accounts for 1% of all breast cancers. Its low frequency leads to a lack of awareness, resulting in significant diagnostic delays. Additionally, this limits the available evidence, which primarily uses diagnostic-therapeutic algorithms based on women.
OBJECTIVE: To analyze the prevalence, clinical presentation, anatomical and pathological characteristics, and prognosis of male breast cancer using one of the largest series available. Secondarily, to compare our data with studies conducted in women.
METHODS: A multicenter, observational, descriptive, retrospective study was conducted in the autonomous community of Aragon, Spain, from 1995 to 2022 including men with a pathological diagnosis of breast cancer.
RESULTS: A total of 148 patients were included, with a prevalence of 1%. The most common clinical presentation was a palpable retroareolar mass. Invasive ductal carcinoma was the most frequent type (88.89%), and luminal B was the predominant subtype (47.76%). Surgery was the most utilized treatment; mastectomy was performed in 90.34% and AL in 46.89%. At diagnosis, 52.46% had extramammary involvement. The recurrence rate was 24.1%, and the mortality attributed to the disease was 14.6%.
CONCLUSIONS: There is a high rate of metastatic involvement at diagnosis, a high percentage of mutilating surgeries, and a high number of recurrences compared to available studies on males. Additionally, a worse prognosis is observed compared to breast cancer in women, despite these tumors having a less aggressive molecular subtype. These findings highlight the importance of conducting studies focused on men to develop specific protocols.