未经证实:卵巢癌(OC)是妇科癌症相关死亡的主要原因。在主要的OC组织学亚型中,侵袭性黏液癌(MC)仅占OC病例的3%,并且通常与良好的预后相关。然而,MC在临床上与其他OC组织学有很大不同,病态,和生物学行为。然而,MC的起源和分子发病机制尚未完全了解。因此,新型诊断标志物的鉴定可能有助于OC的早期诊断,特别是MC组织型,从而导致开发组织型特异性治疗方案并提高存活率。
未经批准:在本研究中,使用95个I-II期OC的RNA测序(RNA-seq)数据将三叶因子基因家族成员(TFF1,TFF2和TFF3)鉴定为MC组织型特异性生物标志物。然后通过免疫组织化学对206个按组织学分层的I-II期OCs评估TFF1,TFF2和TFF3的诊断价值(高级别浆液性癌[HGSC],子宫内膜样癌[EC],透明细胞癌[CCC],和MC)。
UNASSIGNED:我们显示MC样品中TFF1、TFF2和TFF3的胞浆内蛋白表达水平显著升高,从而揭示三叶因子基因家族成员的表达与MC组织型之间的关联。一起来看,这些发现表明,TFF蛋白可能在MC组织型的肿瘤发生和发展中起关键作用.
未经批准:一起,这些发现表明,TFF蛋白可能在MC组织型的肿瘤发生和发展中起关键作用.此外,这些新的组织型特异性诊断生物标志物不仅可以改善早期卵巢癌的患者分层,而且可能是分子靶向治疗的候选药物.
UNASSIGNED: Ovarian cancer (OC) is the leading cause of gynecological cancer-related death. Of the main OC histologic subtypes, invasive mucinous carcinomas (MC) account for only 3% of OC cases and are frequently associated with favorable prognosis. Nevertheless, MCs differ greatly from the other OC histotypes in clinical, pathological, and biological behavior. However, the origin and molecular pathogenesis of MC are not yet fully understood. Therefore, identification of novel diagnostic markers could potentially facilitate early diagnosis of OC, particularly the MC
histotype, thereby leading to the development of
histotype-specific treatment regimens and improved survival rates.
UNASSIGNED: In the present study, Trefoil factor gene family members (TFF1, TFF2 and TFF3) were identified as MC histotype-specific biomarkers using RNA sequencing (RNA-seq) data for 95 stage I-II OCs. The diagnostic value of TFF1, TFF2 and TFF3 was then evaluated by immunohistochemistry on 206 stage I-II OCs stratified by
histotype (high-grade serous carcinoma [HGSC], endometrioid carcinoma [EC], clear cell carcinoma [CCC], and MC).
UNASSIGNED: We showed significantly elevated intracytoplasmic protein expression levels for TFF1, TFF2 and TFF3 in MC samples, thereby revealing an association between expression of Trefoil factor gene family members and the MC
histotype. Taken together, these findings suggest that the TFF proteins may play a pivotal role in tumor initiation and progression for the MC histotype.
UNASSIGNED: Taken together, these findings suggest that the TFF proteins may play a pivotal role in tumor initiation and progression for the MC histotype. Moreover, these novel
histotype-specific diagnostic biomarkers may not only improve patient stratification of early-stage ovarian carcinomas but may also be candidates for the development of molecular targeted therapies.