组蛋白去甲基化酶,负责从组蛋白中去除甲基的酶,已经成为调节基因表达和染色质动力学的关键参与者,从而影响各种细胞过程。LSD2和LSD1由于它们与癌症的关联而在这些脱甲基酶中引起了相当大的兴趣。然而,虽然LSD1受到了极大的关注,LSD2尚未得到同等程度的认可。在这项研究中,我们对LSD2和LSD1进行了全面比较,重点探讨了LSD2的含义。虽然两者在结构上有相似之处,LSD2也具有独特的功能。功能上,LSD2展示了不同的角色,特别是在癌症中,具有组织依赖性的作用。此外,LSD2延伸到组蛋白去甲基化之外,影响DNA甲基化,癌细胞重编程,E3泛素连接酶活性与DNA损伤修复途径.这项研究强调了LSD2的独特作用,为它们对癌症和其他细胞过程的贡献提供了见解。
Histone demethylases, enzymes responsible for removing methyl groups from histone proteins, have emerged as critical players in regulating gene expression and chromatin dynamics, thereby influencing various cellular processes. LSD2 and LSD1 have attracted considerable interest among these demethylases because of their associations with cancer. However, while LSD1 has received significant attention, LSD2 has not been recognized to the same extent. In this study, we conduct a comprehensive comparison between LSD2 and LSD1, with a focus on exploring LSD2\'s implications. While both share structural similarities, LSD2 possesses unique features as well. Functionally, LSD2 shows diverse roles, particularly in cancer, with tissue-dependent roles. Additionally, LSD2 extends beyond histone demethylation, impacting DNA methylation, cancer cell reprogramming, E3 ubiquitin ligase activity and DNA damage repair pathways. This study underscores the distinct roles of LSD2, providing insights into their contributions to cancer and other cellular processes.