背景:囊状挛缩仍然是硅胶乳房植入术的常见并发症。病因,形成机制,诱发因素和偏好因素仍然是研究的主题。这项研究旨在证明与其他已知方法:抗生素和皮质类固醇相比,使用假体周围引入的自体脂肪预防包膜挛缩的有效性。
方法:研究纳入了80只Wistar大鼠的队列,分为四个子组。所有受试者都接受了硅胶植入物,植入沿腹部中线形成的口袋中。第一个亚组作为对照组,在没有任何治疗的情况下放置植入物的受试者。对于第二和第三子组,植入物用抗生素溶液和肌肉注射地塞米松治疗,分别。最后一个亚组的受试者接受经假体周围引入的离心自体脂肪。
结果:具有自体脂肪的亚组表现出明显较小的胶囊厚度,代表性不足,表面光滑。使用自体脂肪治疗硅胶假体与假体部位周围缺乏急性炎症有关。
结论:自体脂肪有助于减少“非自我”反应,这导致形成由散布有脂肪细胞的成熟胶原纤维组成的假体周围囊。
BACKGROUND: Capsular contracture remains a common complication in silicone breast implantation. The etiology, formation mechanisms, predisposing and favoring factors are still subjects of research. This study aims to demonstrate the effectiveness of using autologous fat introduced periprosthetically in preventing capsular contracture compared to other known methods: antibiotics and corticosteroids.
METHODS: A cohort of 80 Wistar rats was included in the study, divided into four subgroups. All subjects received a silicone implant, implanted in a pocket created along the abdominal midline. The first subgroup served as the control group, with subjects having the implant placed without any treatment. For the second and third subgroups, the implants were treated with an antibiotic solution and intramuscular injections of dexamethasone, respectively. The subjects in the last subgroup received centrifuged autologous fat introduced periprosthetically.
RESULTS: The subgroup with autologous fat exhibited a significantly smaller capsule thickness, which was poorly represented, with a smooth surface. The use of autologous fat for treating silicone prosthesis was linked with the lack of acute inflammation around the prosthetic site.
CONCLUSIONS: Autologous fat helps to minimize the \"non-self\" reaction, which results in the development of a periprosthetic capsule consisting of mature collagen fibers interspersed with adipocytes.