肥胖和超重,经常是由缺乏锻炼引起的,与许多代谢疾病相关,比如高血压,糖尿病,和血脂异常。有氧运动能有效提高高密度脂蛋白-胆固醇(HDL-C)水平,减轻甘油三酯(TG)水平。Cubanpolicosanol(Raydel®)的消费在增强HDL-C量和HDL功能以治疗血脂异常和高血压方面也是有效的。另一方面,没有研究对肥胖受试者进行高强度运动和多酚醇摄入联合治疗对改善代谢紊乱的作用进行了研究.在目前的研究中,招募了17名肥胖受试者(平均BMI为30.1±1.1kg/m2,8名男性和9名女性),以参加一项将运动和多酚醇(20mg)消耗相结合的计划,为期12周。完成后,BMI,腰围,总脂肪量,收缩压(SBP),舒张压(DBP)显着降低约-15%,-13%,-33%,-11%,-13%,分别。在血脂谱中,在第12周,观察到总胆固醇(TC)和甘油三酯(TG)水平显着降低,从基线到-17%和-54%,分别。血清HDL-C从基线升高约+12%,以及TC中HDL-C的百分比,和HDL-C/TC(%),在第12周增加了+32%。在第12周时,所有参与者的血清辅酶Q10(CoQ10)水平从基线增加1.2倍。特别是,男性参与者比基线增加1.4倍.血清CoQ10的升高与血清HDL-C的升高相关(r=0.621,p=0.018)。肝功能参数得到改善;血清γ-谷氨酰转移酶在第12周下降高达-55%(p<0.007),而天冬氨酸转氨酶和丙氨酸转氨酶水平在正常范围内降低。在脂蛋白水平,随着TG含量的降低,氧化和糖基化程度显着降低。HDL的抗氧化能力,如对氧磷酶(PON)和三价铁离子还原能力(FRA),在第12周时显著增强了1.8倍和1.6倍。在12周内HDL的颗粒大小和数量升高至+10%,随着TG含量的显著下降,糖化程度,和氧化。HDL质量和功能的改善与成年斑马鱼及其胚胎的更高生存能力有关,在羧甲基赖氨酸(CML)的共存下,一种已知会导致急性死亡的促炎分子。总之,12周的古巴policosanol(Raydel®,20mg)的消耗与高强度运动显示出血压的显着改善,身体脂肪量,血脂没有肝损伤,辅酶Q10代谢,和肾功能损害。
Obesity and overweight, frequently caused by a lack of exercise, are associated with many metabolic diseases, such as hypertension, diabetes, and dyslipidemia. Aerobic exercise effectively increases the high-density lipoproteins-cholesterol (HDL-C) levels and alleviates the triglyceride (TG) levels. The consumption of Cuban policosanol (Raydel®) is also effective in enhancing the HDL-C quantity and HDL functionality to treat dyslipidemia and hypertension. On the other hand, no study has examined the effects of a combination of high-intensity exercise and policosanol consumption in obese subjects to improve metabolic disorders. In the current study, 17 obese subjects (average BMI 30.1 ± 1.1 kg/m2, eight male and nine female) were recruited to participate in a program combining exercise and policosanol (20 mg) consumption for 12 weeks. After completion, their BMI, waist circumference, total fat mass, systolic blood pressure (SBP), and diastolic blood pressure (DBP) reduced significantly up to around -15%, -13%, -33%, -11%, and -13%, respectively. In the serum lipid profile, at Week 12, a significant reduction was observed in the total cholesterol (TC) and triglyceride (TG) levels, up to -17% and -54% from the baseline, respectively. The serum HDL-C was elevated by approximately +12% from the baseline, as well as the percentage of HDL-C in TC, and HDL-C/TC (%), was enhanced by up to +32% at Week 12. The serum coenzyme Q10 (CoQ10) level was increased 1.2-fold from the baseline in all participants at Week 12. In particular, the male participants exhibited a 1.4-fold increase from the baseline. The larger rise in serum CoQ10 was correlated with the larger increase in the serum HDL-C (r = 0.621, p = 0.018). The hepatic function parameters were improved; the serum γ-glutamyl transferase decreased at Week 12 by up to -55% (p < 0.007), while the aspartate aminotransferase and alanine transaminase levels diminished within the normal range. In the lipoprotein level, the extent of oxidation and glycation were reduced significantly with the reduction in TG content. The antioxidant abilities of HDL, such as paraoxonase (PON) and ferric ion reduction ability (FRA), were enhanced significantly by up to 1.8-fold and 1.6-fold at Week 12. The particle size and number of HDL were elevated up to +10% during the 12 weeks, with a remarkable decline in the TG content, glycation extent, and oxidation. The improvements in HDL quality and functionality were linked to the higher survivability of adult zebrafish and their embryos, under the co-presence of carboxymethyllysine (CML), a pro-inflammatory molecule known to cause acute death. In conclusion, 12 weeks of Cuban policosanol (Raydel®, 20 mg) consumption with high-intensity exercise displayed a significant improvement in blood pressure, body fat mass, blood lipid profile without liver damage, CoQ10 metabolism, and renal impairment.