背景:尽管已经描述了许多个别病例和小系列的化疗毒性红斑(TEC),所有的研究结果还没有得到很好的理解。
目的:对TEC的临床和组织病理学特征进行全面综述,重点关注新的组织病理学发现。
方法:我们搜索了我们的电子病历中的“化疗毒性红斑”或“中性粒细胞内分泌汗腺炎”。“确定了56例符合临床和组织病理学标准的病例。回顾性审查了电子病历以及随附的苏木精和伊红染色的载玻片。
结果:临床表现是不均匀的,但包括典型的表现,如三菌间出疹(34%)和肢端红斑(25%)。最常见的组织病理学特征是凋亡的角质形成细胞(95%),基底空泡改变(91%),和上皮不成熟(79%)。超过一半的病例(33/56;59%)可见分泌鳞状注射器化生,而嗜中性内分泌汗腺炎并不常见(16%)。有趣的是,许多病例表现出突出的间质组织细胞(55%)。其他新发现包括不规则性角化过度(23%),不规则表皮增生(14%),和棘层松解(9%)。
结论:作为一项回顾性研究,它受到信息偏见的影响。
结论:这是TEC报道的最大系列。除了确认以前报告的功能外,我们确定了新的组织病理学发现,以增加TEC的范围。
BACKGROUND: Although many individual cases and small series of toxic erythema of chemotherapy (TEC) have been described, the full spectrum of findings is not well understood.
OBJECTIVE: To provide a comprehensive review of the clinical and histopathologic features of TEC with an emphasis on novel histopathologic findings.
METHODS: We searched our electronic medical record for \"toxic erythema of chemotherapy\" or \"neutrophilic eccrine
hidradenitis.\" Fifty-six cases meeting clinical and histopathologic criteria were identified. The electronic medical record and accompanying hematoxylin and eosin-stained slides were retrospectively reviewed.
RESULTS: The clinical findings were heterogeneous but included classic presentations such as intertriginous eruptions (34%) and acral erythema (25%). The most common histopathologic features were apoptotic keratinocytes (95%), basal vacuolar change (91%), and epithelial dysmaturation (79%). Eccrine squamous syringometaplasia was seen in over half of the cases (33/56; 59%), whereas neutrophilic eccrine
hidradenitis was uncommon (16%). Interestingly, many cases showed prominent interstitial histiocytes (55%). Other novel findings included irregular orthohyperkeratosis (23%), irregular epidermal hyperplasia (14%), and acantholysis (9%).
CONCLUSIONS: As a retrospective study, it is subject to information bias.
CONCLUSIONS: This is the largest reported series of TEC. In addition to confirming previously reported features, we identify novel histopathologic findings to add to the spectrum of TEC.