■肝毒性是临床医生的首要问题,也是药品召回的主要原因。生物标志物是用于评估治疗功效或诊断疾病的可测量和可量化的属性。有各种生物标志物用于检测肝病和肝损伤的意图。
■这篇综述旨在研究肝毒性生物标志物的现状及其在临床环境中的实用性。使用肝脏生物标志物,肝损伤的存在,其严重性,预后,病原体,和肝毒性的类型都可以确定。
■从MEDLINE/PubMed系统检索了截至2022年的相关发表文章,Scopus,EMBASE,和WOS数据库使用关键词,如药物毒性,肝毒性生物标志物,生化参数,和非酒精性脂肪性肝病。
■在临床试验和日常实践中,药物性肝损伤的生物标志物对于发现最严重的肝毒性病例至关重要。因此,开发新的生物标志物方法来增强肝毒性诊断将增加特异性和/或识别有风险的人。重要的是,对肝病患者的早期临床研究证明,一些生物标志物,如转氨酶,胆红素,白蛋白,和胆汁酸甚至在治疗上是有益的。
■通过评估肝损伤的独特体征,医疗保健专业人员可以快速准确地检测肝损伤并评估其严重程度。这些措施有助于确保及时有效的医疗干预,因此降低了长期肝损伤和其他主要健康问题的风险。
UNASSIGNED: Hepatotoxicity is the foremost issue for clinicians and the primary reason for pharmaceutical product recalls. A biomarker is a measurable and quantifiable attribute used to evaluate the efficacy of a treatment or to diagnose a disease. There are various biomarkers which are used for the detection of liver disease and the intent of liver damage.
UNASSIGNED: This review aims to investigate the current state of hepatotoxicity biomarkers and their utility in clinical settings. Using hepatic biomarkers, the presence of liver injury, its severity, prognosis, causative agent, and type of hepatotoxicity can all be determined.
UNASSIGNED: Relevant published articles up to 2022 were systematically retrieved from MEDLINE/PubMed, SCOPUS, EMBASE, and WOS databases using keywords such as drug toxicity, hepatotoxicity biomarkers, biochemical parameters, and nonalcoholic fatty liver disease.
UNASSIGNED: In clinical trials and everyday practice, biomarkers of drug-induced liver injury are essential for spotting the most severe cases of hepatotoxicity. Hence, developing novel biomarker approaches to enhance hepatotoxicity diagnosis will increase specificity and/or identify the person at risk. Importantly, early clinical studies on patients with liver illness have proved that some biomarkers such as aminotransferase, bilirubin, albumin, and bile acids are even therapeutically beneficial.
UNASSIGNED: By assessing the unique signs of liver injury, health care professionals can rapidly and accurately detect liver damage and evaluate its severity. These measures contribute to ensuring prompt and effective medical intervention, hence reducing the risk of long-term liver damage and other major health concerns.