■膝关节骨性关节炎(OA)是最常见和最衰弱的疾病之一,尤其是老年人。大麻籽油是一种植物产品,由于其抗炎和镇痛特性,自古以来就被用作食品或药物。
方法:双盲,活跃,我们进行了安慰剂对照试验,以评估大麻籽油对膝关节OA的疗效.90例患者被随机分为三组;大麻籽油,双氯芬酸凝胶,和安慰剂通过封闭的随机方法,并被要求每天应用局部治疗2个月。研究参与者之前接受过评估,干预后4周和8周。评估包括测量脚跟到大腿的距离,西安大略省和麦克马斯特大学骨关节炎指数(WOMAC)的利用,并应用视觉模拟量表(VAS)。使用SPSS.24进行数据分析,显著性水平被认为是p<0.05。
结果:所有参数,除了脚跟到大腿的距离,与安慰剂组相比,大麻籽油组的改善显着。与大麻籽油和双氯芬酸凝胶组相比,VAS和WOMAC参数的改善没有差异。研究期间,所有组的脚跟到大腿距离均显着降低。与三组相比,脚跟到大腿距离的改善没有显着差异。
■大麻籽油导致VAS疼痛评分和WOMAC参数的更大改善,但不是膝盖屈曲范围,与安慰剂相比。比较大麻籽油和双氯芬酸凝胶的测量结果没有差异。
UNASSIGNED: Knee osteoarthritis (OA) is one of the most common and debilitating diseases, especially in the elderly.
Hemp seed oil is a plant product that has been used as a food or drug since ancient times because of its anti-inflammatory and analgesic properties.
METHODS: A double-blind, active, placebo-controlled trial was done to assess the efficacy of
hemp seed oil on knee OA. Ninety patients were randomly allocated to three groups;
hemp seed oil, diclofenac gel, and placebo via a blocked randomization method, and were asked to apply the topical treatment daily for 2 months. The study participant underwent assessments before, and four and 8 weeks after the intervention. Evaluation included measurements of the heel-to-thigh distance, utilization of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and application of visual analog scale (VAS). Data analysis was performed using SPSS.24 and the significance level was considered as p < .05.
RESULTS: All parameters, except heel-to-thigh distance, improved significantly in the
hemp seed oil group compared to placebo group. Improvements in VAS and WOMAC parameters were not different comparing the hemp seed oil and diclofenac gel groups. Heel-to-thigh distance decreased significantly within all groups during the study. There were no significant differences in improvements in heel-to-thigh distance comparing the three groups.
UNASSIGNED: Hemp seed oil led to greater improvements in VAS pain score and WOMAC parameters, but not knee flexion range, compared to placebo. There were no differences in measured outcomes comparing
hemp seed oil and diclofenac gel.