创伤性脑损伤(TBI)是一个多方面的健康问题,在整个人群中表现出不同的影响。这项研究探讨了TBI在性别特定背景下的生物力学复杂性,专注于女性。我们的主要目标是调查与女性相关的独特损伤机制和风险,强调在这个队列中进行量身定制的调查的必要性。通过采用流体-结构相互作用(FSI)分析,我们进行了模拟,以量化不同年龄段女性对创伤力的生物力学反应。该研究利用缩放技术来创建有限元模型(FEM)。年轻的女性FEM,根据人体测量数据,与年轻男性FEM相比,头部几何形状小15%。此外,虽然老年女性FEM在大多数结构方面都与年轻女性FEM密切相关,它显示出独特的特征,例如脑萎缩和脑脊液(CSF)层厚度增加。值得注意的是,儿童女性FEM(7-11岁)复制了约95%的年轻女性FEM几何形状。这些结构性差异精心捕捉了我们建模的女性年龄组的特定年龄差异。值得注意的是,相同的条件,包括冲击强度,加载类型,和边界条件,在此生物力学有限元分析中,所有FEM都保持不变,确保比较结果。研究结果揭示了不同年龄段的额叶和枕骨压力的显着差异,强调女性TBI易感性的潜在年龄相关差异。这些变化主要与解剖特征的差异有关,包括脑容量,脑脊液厚度,和大脑状况,asthesamematerialpropertieswereusedintheFEMs.Theseresultswereapproximately4.70,6.33and6.43%inforearareaofbrainindifferentagegroupoffemale(young,老年人,和儿童)分别与年轻男性FEM进行比较。比较年轻女性和老年女性的有限元结果,我们在同一点观察到枕骨脑压下降,从171,993减少到167,793Pa,标志着大约2.5%的下降。虽然与年轻人相比,老年人通常表现出更大的大脑脆弱性,我们的发现显示了大脑压力的降低。值得注意的是,在评估大脑和颅骨在枕骨区域的相对移动时,与年轻女性(1.04mm)相比,老年人(1.8mm)的相对运动更大。因此,脑萎缩增加了大脑在颅空间内的运动范围。该研究强调了针对年龄和性别进行细致入微的TBI风险评估的关键必要性。强调特定年龄的保护策略在跨不同人口统计学管理TBI中的重要性。未来的研究采用个人建模技术和探索更广泛的年龄范围有望完善我们对TBI机制的理解,并采用有针对性的方法来减轻不同群体的TBI。
Traumatic Brain Injury (TBI) stands as a multifaceted health concern, exhibiting varying influences across human population. This study delves into the biomechanical complexities of TBI within gender-specific contexts, focusing on females. Our primary objective is to investigate distinctive injury mechanisms and risks associated with females, emphasizing the imperative for tailored investigations within this cohort. By employing Fluid-Structure Interaction (FSI) Analysis, we conducted simulations to quantify biomechanical responses to traumatic forces across diverse age groups of females. The study utilized a scaling technique to create finite element models (FEMs). The young female FEM, based on anthropometric data, showcased a 15 % smaller head geometry compared to the young male FEM. Moreover, while the elderly female FEM closely mirrored the young female FEM in most structural aspects, it showed distinctive features such as brain atrophy and increased cerebrospinal fluid (CSF) layer thickness. Notably, the child female FEM (ages 7-11 years) replicated around 95 % of the young female FEM\'s geometry. These structural distinctions meticulously captured age-specific variations across our modeled female age groups. It\'s noteworthy that identical conditions, encompassing impact intensity, loading type, and boundary conditions, were maintained across all FEMs in this biomechanical finite element analysis, ensuring comparative results. The findings unveiled significant variations in frontal and occipital pressures among diverse age groups, highlighting potential age-related discrepancies in TBI susceptibility among females. These variations were primarily linked to differences in anatomical features, including brain volume, CSF thickness, and brain condition, as the same material properties were used in the FEMs. These results were approximately 4.70, 6.33 and 6.43 % in frontal area of brain in diverse age groups of females (young, elderly, and child) respectively compared to young male FEM. Comparing the FEM results between the young female and the elderly female, we observed a decrease in occipital brain pressure at the same point, reducing from 171,993 to 167,793 Pa, marking an approximate 2.5 % decrease. While typically the elderly exhibit greater brain vulnerability compared to the young, our findings showcase a reduction in brain pressure. Notably, upon assessing the relative movement between the brain and the skull at the point located in occipital area, we observed greater relative movement in the elderly (1.8 mm) compared to the young female (1.04 mm). Therefore, brain atrophy increases the range of motion of the brain within the cranial space. The study underscores the critical necessity for nuanced TBI risk assessment tailored to age and gender, emphasizing the importance of age-specific protective strategies in managing TBIs across diverse demographics. Future research employing individual modeling techniques and exploring a wider age spectrum holds promise in refining our understanding of TBI mechanisms and adopting targeted approaches to mitigate TBI in diverse groups.