背景:心理弹性被定义为个体成功适应挑战性生活经历的过程和结果。已知Habenula(Hb)参与应激反应;然而,人类血红蛋白量与恢复力之间的关系尚不清楚。本研究调查了韧性之间的相关性,Hb音量,和成年人的抑郁倾向。
方法:使用深度学习技术对110名健康参与者进行Hb体积评估。使用Connor-Davidson弹性量表和Beck抑郁量表-II评估弹性和抑郁,分别。我们研究了血红蛋白量与弹性之间的关系,并评估了弹性对血红蛋白量与抑郁倾向之间关系的中介作用。
结果:相关分析显示韧性与Hb体积呈正相关(部分r=0.176,p=0.001),这在女性中更为明显(部分r=0.353,p=0.003)。左侧和右侧的Hb体积表现出显著的侧向化(LI=0.031,95%CI=[0.016,0.046])。尽管Hb不对称,偏侧化与韧性没有显著相关。调解分析显示,韧性对血红蛋白量和抑郁倾向之间的关系有显著的间接影响(β=-0.093,95CI=[-0.189,-0.019])。
结论:这项研究发现,恢复力较低的人群Hb体积较小。先前的研究表明,随着患者抑郁症状严重程度的增加,Hb体积减少。我们的发现支持这一观点,并将其扩展到尚未被临床诊断为抑郁症的人群。此外,我们发现心理弹性可以通过血红蛋白量来预测,并且可以作为间接影响抑郁倾向的中介因素,即使是健康的个体。
结论:由于其横截面设计,本研究无法分析韧性适应过程中Hb量的动态变化。
BACKGROUND: Psychological resilience is defined as the process and outcome of individuals\' successful adaptation to challenging life experiences. The
Habenula (Hb) is known to be involved in the stress response; however, the relationship between Hb volume and resilience in humans remains unclear. This study investigated the correlation among resilience, Hb volume, and depressive tendencies in adults.
METHODS: Hb volumes were assessed using deep learning techniques applied to 110 healthy participants. Resilience and depression were evaluated using the Connor-Davidson Resilience Scale and Beck Depression Inventory-II, respectively. We examined the relationship between Hb volume and resilience and assessed the mediating effects of resilience on the relationship between Hb volume and depressive tendencies.
RESULTS: Correlation analysis revealed a positive correlation between resilience and Hb volume (partial r = 0.176, p = 0.001), which was more pronounced in women (partial r = 0.353, p = 0.003). Hb volumes on the left and right sides exhibited significant lateralization (LI = 0.031, 95 % CI = [0.016, 0.046]). Despite Hb asymmetry, lateralization was not significantly associated with resilience. The mediation analysis shows significant indirect effect of resilience on the relationship between Hb volume and depressive tendencies (β = -0.093, 95%CI = [-0.189, -0.019]).
CONCLUSIONS: This study found that populations with lower resilience have smaller Hb volume. Previous research has shown that Hb volume decreased with the increasing severity of depression symptoms in patients. Our findings support this view and extend it to a population that has not been clinically diagnosed with depression. Additionally, we found that psychological resilience can be predicted by Hb volume and may serve as a mediating factor indirectly affecting depressive tendencies, even in healthy individuals.
CONCLUSIONS: Due to its cross-sectional design, this study was unable to analyze dynamic changes in Hb volume during the process of resilience adaptation.