■妊娠糖尿病,以孕妇血糖升高为特征的常见妊娠并发症,会对母亲和胎儿造成严重的不良影响,包括羊水增加和胎儿窒息的风险,缺氧,和早产。
■构建预测模型,分析妊娠期糖尿病分娩中巨大儿的危险因素。
■从2021年1月到2023年2月,选择了362名患有妊娠糖尿病的孕妇进行研究。他们被跟踪直到交货。根据新生儿出生体重,参与者被分为巨大儿组(出生体重4000g)和非巨大儿组(出生体重<4000g)。比较两组孕妇的数据。绘制ROC曲线,分析多因素对妊娠期糖尿病孕妇大体儿分娩的预测价值。建立了逻辑回归模型以确定分娩宏观婴儿的危险因素,并对模型进行了测试。
■共包括362名妊娠糖尿病孕妇,其中58例(16.02%)婴儿患有巨大儿。与没有巨大儿的人群相比,巨大儿人群在几个方面表现出更高的指标:孕前BMI,空腹血糖,1小时和2小时OGTT糖水平,怀孕期间体重增加,和甘油三酯的水平,LDL-C,和HDL-C,差异均有统计学意义(P<0.05)。ROC分析显示巨大儿的预测价值,AUC为0.761(孕前BMI),0.710(空腹血糖),0.671(1小时OGTT),0.634(2小时OGTT),0.850(体重增加),0.837(甘油三酯),0.742(LDL-C),和0.776(HDL-C),有统计学意义(P<0.05)。Logistic回归确定孕前BMI高,空腹血糖,体重增加,甘油三酯,和LDL-C水平作为巨大儿的独立危险因素,赔率比分别为2.448、2.730、1.884、16.919和5.667,均有统计学意义(P<0.05)。模型的AUC为0.980(P<0.05),证明了其可靠性和稳定性。
■妊娠期糖尿病大体婴儿的分娩可能与怀孕前的体重指数等因素有关,血糖水平,怀孕期间体重增加,和脂质水平。应实施针对这些因素的临床干预措施,以减少巨大儿的发生率。
UNASSIGNED: Gestational diabetes, a frequent pregnancy complication marked by elevated maternal blood glucose, can cause serious adverse effects for both mother and fetus, including increased amniotic fluid and risks of fetal asphyxia, hypoxia, and premature birth.
UNASSIGNED: To construct a predictive model to analyze the risk factors for macrosomia in deliveries with gestational diabetes.
UNASSIGNED: From January 2021 to February 2023, 362 pregnant women with gestational diabetes were selected for the study. They were followed up until delivery. Based on newborn birth weight, the participants were divided into the macrosomia group (birth weight ⩾ 4000 g) and the non-macrosomia group (birth weight < 4000 g). The data of the two groups of pregnant women were compared. ROC curves were plotted to analyze the predictive value of multiple factors for the delivery of macrosomic infants among pregnant women with gestational diabetes. A logistic regression model was constructed to identify the risk factors for delivering macrosomic infants and the model was tested.
UNASSIGNED: A total of 362 pregnant women with gestational diabetes were included, of which 58 (16.02%) had babies with macrosomia. The macrosomia group exhibited higher metrics in several areas compared to those without: pre-pregnancy BMI, fasting glucose, 1 h and 2 h OGTT sugar levels, weight gain during pregnancy, and levels of triglycerides, LDL-C, and HDL-C, all with significant differences (P< 0.05). ROC analysis revealed predictive value for macrosomia with AUCs of 0.761 (pre-pregnancy BMI), 0.710 (fasting glucose), 0.671 (1 h OGTT), 0.634 (2 h OGTT), 0.850 (weight gain), 0.837 (triglycerides), 0.742 (LDL-C), and 0.776 (HDL-C), indicating statistical significance (P< 0.05). Logistic regression identified high pre-pregnancy BMI, fasting glucose, weight gain, triglycerides, and LDL-C levels as independent risk factors for macrosomia, with odds ratios of 2.448, 2.730, 1.884, 16.919, and 5.667, respectively, and all were statistically significant (P< 0.05). The model\'s AUC of 0.980 (P< 0.05) attests to its reliability and stability.
UNASSIGNED: The delivery of macrosomic infants in gestational diabetes may be related to factors such as body mass index before pregnancy, blood-glucose levels, gain weight during pregnancy, and lipid levels. Clinical interventions targeting these factors should be implemented to reduce the incidence of macrosomia.