■观察性研究的证据表明慢性乙型肝炎(CHB)与心血管疾病(CVD)有关。然而,结果不一致,因果关系尚待确定。我们利用两个样本孟德尔随机化(MR)来调查CHB和CVD之间的潜在因果关联,包括动脉粥样硬化,冠心病,高血压,和缺血性中风。
■分析是通过全基因组关联研究(GWAS)进行的,考虑慢性乙型肝炎作为暴露和心血管疾病作为终点。在此分析中,评估因果关系的主要方法是逆方差加权(IVW)技术。此外,我们采用了加权中位数,MR-Egger回归,加权模式,和补充分析的简单模式方法。最后,异质性测试,敏感性分析,并进行了多重效应分析。
■在随机效应IVW分析中,我们发现慢性乙型肝炎的遗传易感性与动脉粥样硬化风险增加相关[OR=1.048,95%CI(1.022-1.075),P=3.08E-04],以及冠心病风险增加[OR=1.039,95%CI(1.006-1.072),P=0.020]。然而,与缺血性卒中风险呈负相关[OR=0.972,95%CI(0.957-0.988),P=4.13E-04]。没有证据表明慢性乙型肝炎与高血压相关[OR=1.021,95%CI(0.994-1.049),P=0.121]。
■我们的研究表明,慢性乙型肝炎与发展动脉粥样硬化和冠心病的风险升高有关,而与缺血性卒中风险降低相关。
UNASSIGNED: Evidence from observational studies suggests that chronic hepatitis B (CHB) is associated with cardiovascular disease (CVD). However, results have been inconsistent and causality remains to be established. We utilized two-sample Mendelian randomization (MR) to investigate potential causal associations between CHB and CVD, including atherosclerosis, coronary heart disease, hypertension, and ischemic stroke.
UNASSIGNED: The analysis was conducted through genome-wide association studies (GWAS), considering chronic hepatitis B as the exposure and cardiovascular disease as the endpoint. The primary method for evaluating causality in this analysis was the inverse-variance weighted (IVW) technique. Additionally, we employed the weighted median, MR-Egger regression, weighted mode, and simple mode methods for supplementary analyses. Finally, heterogeneity tests, sensitivity analyses, and multiple effects analyses were conducted.
UNASSIGNED: In a random-effects IVW analysis, we found that genetic susceptibility to chronic hepatitis B was associated with an increased risk of atherosclerosis [OR = 1.048, 95% CI (1.022-1.075), P = 3.08E-04], as well as an increased risk of coronary heart disease [OR = 1.039, 95% CI (1.006-1.072), P = 0.020]. However, it was found to be inversely correlated with ischemic stroke risk [OR = 0.972, 95% CI (0.957-0.988), P = 4.13E-04]. There was no evidence that chronic hepatitis B was associated with hypertension [OR = 1.021, 95% CI (0.994-1.049), P = 0.121].
UNASSIGNED: Our research indicates that chronic hepatitis B has a correlation with an elevated risk of developing atherosclerosis and coronary heart disease, while it is associated with a decreased risk of experiencing an ischemic stroke.