UNASSIGNED:本研究旨在分析扩大抗逆转录病毒治疗(ART)后中国西南地区农村地区HIV性传播的遗传网络,并通过遗传网络探讨HIV性传播的相关因素。
UNASSIGNED:这是广西的一项纵向遗传网络研究,中国。基线调查和随访研究分别在2015年和2016年至2018年新诊断的HIV患者中进行。采用广义估计方程模型通过新诊断的HIV患者(2016-2018)和基线患者(2015-2017)之间的遗传联系来探索与HIV传播相关的因素。分别。
未经证实:在3,259个确定的HIV患者序列中,2,714名患者处于基线,545名新诊断为HIV患者。通过重复测量分析共观察到8,691个基线目标。治疗的HIV患者在HIV传播中的预防功效为33%[调整比值比(AOR):0.67,95%置信区间(CI):0.48-0.93]。分层分析表明,对于病毒载量(VL)<50拷贝/ml的接受治疗的HIV患者和VL<50拷贝/ml的接受治疗4年的HIV患者,其HIV传播的预防功效为41[AOR:0.59,95%CI:0.43-0.82]和65%[AOR:0.35,95%CI:0.24-0.50],分别。在接受治疗的VL缺失的HIV患者或接受治疗的HIV患者中,HIV传播没有显着减少。一些因素与艾滋病毒传播有关,包括50岁以上的人,男人,壮族等民族,低于中等教育,作为一个农民,和异性传播。
UNASSIGNED:这项研究揭示了ART在减少HIV传播中的作用,和那些年龄较大的男性农民,低于中学教育水平在人口水平上感染艾滋病毒的风险很高。迫切需要提高HIV患者的ART疗效,并在ART扩展过程中对高危人群进行精确干预。
UNASSIGNED: This study is used to analyze the genetic network of HIV sexual transmission in rural areas of Southwest China after expanding antiretroviral therapy (ART) and to investigate the factors associated with HIV sexual transmission through the genetic network.
UNASSIGNED: This was a longitudinal genetic network study in Guangxi, China. The baseline survey and follow-up study were conducted among patients with HIV in 2015, and among those newly diagnosed from 2016 to 2018, respectively. A generalized estimating equation model was employed to explore the factors associated with HIV transmission through the genetic linkage between newly diagnosed patients with HIV (2016-2018) and those at baseline (2015-2017), respectively.
UNASSIGNED: Of 3,259 identified HIV patient sequences, 2,714 patients were at baseline, and 545 were newly diagnosed patients with HIV at follow-up. A total of 8,691 baseline objectives were observed by repeated measurement analysis. The prevention efficacy in HIV transmission for treated HIV patients was 33% [adjusted odds ratio (AOR): 0.67, 95% confidence interval (CI): 0.48-0.93]. Stratified analyses indicated the prevention efficacy in HIV transmission for treated HIV patients with a viral load (VL) of <50 copies/ml and those treated for 4 years with a VL of <50 copies/ml to be 41 [AOR: 0.59, 95% CI: 0.43-0.82] and 65% [AOR: 0.35, 95% CI: 0.24-0.50], respectively. No significant reduction in HIV transmission occurred among treated HIV patients with VL missing or treated HIV patients on dropout. Some factors were associated with HIV transmission, including over 50 years old, men, Zhuang and other nationalities, with less than secondary schooling, working as a farmer, and heterosexual transmission.
UNASSIGNED: This study reveals the role of ART in reducing HIV transmission, and those older male farmers with less than secondary schooling are at high risk of HIV infection at a population level. Improvements to ART efficacy for patients with HIV and precision intervention on high-risk individuals during the expansion of ART are urgently required.