general medicine

普通医学
  • 文章类型: Journal Article
    女医生人数的增加与她们在学术职位和专业协会中的代表性不足形成鲜明对比。本研究旨在根据社会成员资格评估日本医院综合医学学会(JHGM)中女医生的地位,董事会成员,和年度会议作者身份。
    进行横截面分析。关于女医生的信息,社会和董事会成员,收集了年会作者身份。来自日本初级保健协会(JPCA)的数据作为对照。在JHGM和JPCA年会中接受摘要的作者的性别由姓名或互联网搜索确定。
    在JHGM中,14.2%的成员是女医生,与JPCA中的19.1%(p<0.001)相比。21名JHGM董事会成员中没有一名是女性,与JPCA中的20.5%相比(p<0.001)。JHGM董事会成员的平均经验年数明显高于JPCA董事会成员(37.0vs.28.1年,p<0.001)。2022-2023年JHGM会议的女性第一作者占17.9%,显著低于2023年JPCA会议的28.4%(p=0.002)。女性最后一位作者也看到了类似的模式(JHGM中的6.0%与JPCA中的18.8%,p<0.001)和女性主席(JHGM中的17.9%与JPCA中的40.3%,p=0.036)。
    JHGM在社会和董事会成员中的女性代表性较低,和年度会议作者身份。需要采取战略,通过增加妇女在JHGM中的参与和领导来增强多样性和包容性。
    UNASSIGNED: The increasing number of women physicians is in contrast to their underrepresentation in academic positions and professional associations. This study aimed to evaluate the status of women physicians in the Japanese Society of Hospital General Medicine (JHGM) based on society membership, board membership, and annual meeting authorship.
    UNASSIGNED: A cross-sectional analysis was conducted. Information on women physicians, society and board membership, and annual meeting authorship was collected. Data from the Japanese Primary Care Association (JPCA) served as the control. The gender of authors with accepted abstracts in the JHGM and JPCA annual meetings was determined by name or Internet search.
    UNASSIGNED: In the JHGM, 14.2% of members were women physicians, compared to 19.1% in the JPCA (p < 0.001). None of the 21 JHGM board members were women, compared to 20.5% in the JPCA (p < 0.001). The average number of years of experience was significantly higher for the JHGM board members than for the JPCA board members (37.0 vs. 28.1 years, p < 0.001). Women first authors in the 2022-2023 JHGM meeting comprised 17.9%, significantly lower than the 28.4% in the 2023 JPCA meeting (p = 0.002). Similar patterns were seen for women last authors (6.0% in the JHGM vs. 18.8% in the JPCA, p < 0.001) and women chairpersons (17.9% in the JHGM vs. 40.3% in the JPCA, p = 0.036).
    UNASSIGNED: The JHGM has low women representation in society and board membership, and annual meeting authorship. Strategies are needed to enhance diversity and inclusion by increasing women\'s participation and leadership in the JHGM.
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  • 文章类型: Case Reports
    一名50岁的男子出现发烧和全身皮疹,患有慢性疲劳和淋巴结病一年半。初步测试排除了淋巴增生性疾病,显示反应性增生和巨细胞病毒。氨苄青霉素治疗后症状恶化,导致疑似药物诱发的超敏反应综合征(DIHS)。一被录取,停用了阿莫西林,启动泼尼松龙和抗病毒治疗。这种疗法使病人的病情得到改善。药物诱导的淋巴细胞刺激试验证实了对氨苄青霉素和别嘌呤醇的超敏反应。由于罕见的表现,该病例说明了慢性和急性DIHS的诊断挑战。它强调了对慢性淋巴结病和疲劳患者高度怀疑DIHS的必要性,特别是最近的药物暴露。有效的管理包括识别症状,撤回令人反感的药物,使用皮质类固醇。巨细胞病毒等病毒感染会使DIHS诊断和治疗复杂化,需要采取全面的方法。这个案例强调了在鉴别诊断中考虑DIHS的重要性,以及在农村医疗机构中与共感染一起管理DIHS的复杂性。
    A 50-year-old man presented with fever and a generalized rash, with chronic fatigue and lymphadenopathy for a year and a half. Initial tests ruled out lymphoproliferative disorders, showing reactive hyperplasia and cytomegalovirus. Symptoms worsened after ampicillin treatment, leading to suspected drug-induced hypersensitivity syndrome (DIHS). Upon admission, amoxicillin was discontinued, and prednisolone and antiviral treatment were initiated. The patient\'s condition improved with this therapy. A drug-induced lymphocyte stimulation test confirmed hypersensitivity to both ampicillin and allopurinol. This case illustrates the diagnostic challenge of chronic and acute DIHS because of the rare presentation. It underscores the need for high suspicion of DIHS in patients with chronic lymphadenopathy and fatigue, particularly with recent drug exposure. Effective management involves recognizing symptoms, withdrawing the offending drug, and using corticosteroids. Viral infections like cytomegalovirus can complicate DIHS diagnosis and treatment, necessitating a comprehensive approach. This case highlights the importance of considering DIHS in differential diagnoses and the complexities of managing it alongside co-infections in rural healthcare settings.
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  • 文章类型: Case Reports
    本病例报告讨论了一名具有复杂病史的68岁男性患者抗中性粒细胞胞浆抗体(ANCA)阴性快速进展性肾小球肾炎(RPGN)的治疗。呈现疲劳,水肿,和急性肾衰竭.尽管没有特定RPGN类型的阳性生物标志物,临床进展提示显微镜下多血管炎,导致环磷酰胺和利妥昔单抗的强化免疫抑制治疗。患者的病情因肾病综合征和肾病综合征的共存而进一步复杂化,需要细致入微的管理策略,包括长时间的血液透析.最初治疗失败后,最终实现了缓解,允许停止透析和肾功能的显着恢复。此案例凸显了诊断和管理ANCA阴性RPGN的挑战,特别是量身定做的重要性,资源有限环境下的动态治疗方法。观察到的恢复强调了肾功能改善的潜力,即使经过长时间的强化治疗,加强管理复杂RPGN病例对持久性和适应性的需求。
    This case report discusses the management of anti-neutrophil cytoplasmic antibodies (ANCA)-negative rapid progressive glomerulonephritis (RPGN) in a 68-year-old man with a complex medical history, presenting with fatigue, edema, and acute renal failure. Despite the absence of positive biomarkers for specific RPGN types, the clinical progression suggested microscopic polyangiitis, leading to intensive immunosuppressive therapy with cyclophosphamide and rituximab. The patient\'s condition was further complicated by the coexistence of nephritic and nephrotic syndromes, requiring nuanced management strategies, including prolonged hemodialysis. After initial treatment failure, remission was eventually achieved, allowing cessation of dialysis and significant recovery of renal function. This case highlights the challenges of diagnosing and managing ANCA-negative RPGN, particularly the importance of a tailored, dynamic approach to treatment in resource-limited settings. The recovery observed underscores the potential for renal function improvement even after prolonged periods of intensive therapy, reinforcing the need for persistence and adaptability in managing complex RPGN cases.
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  • 文章类型: Journal Article
    背景:研究的主要目的是验证Zulfiqar虚弱量表(ZFS),并检查其与改良的短期急诊老年评估(mSEGA)量表的一致性,
    方法:在瓜德罗普岛(法国)进行了为期两个月的前瞻性观察研究(从2024年2月20日至4月20日)。涉及65岁及以上的老年人,认为自给自足,ADL(日常生活活动)得分超过六分中的四分。
    结果:在这个由98个人组成的社区队列中,平均75岁,根据修改后的SEGA标准,29%的人身体虚弱。根据“ZFS”评分,虚弱占40%。在我们的研究中确定的脆弱的关键预测因素包括年龄,合并症(Charlson评分),多药(药物和治疗类的总数),和功能能力(ADL评分)。值得注意的是,根据ZFS和SEGA量表,过去6个月内的跌倒和住院经历显著影响了虚弱分类.与家庭护理助手的存在显著关联(p<0.0001),单足支撑试验结果(p<0.0001),记忆障碍(p<0.0001),最近住院(p=0.0054)强调了虚弱的多维影响。SEGA和Zulfiqar脆弱量表之间的Pearson相关系数及其95%置信区间为0.73[0.61:0.81]。脆弱的识别阈值设定为六个标准中的三个,显示64%的灵敏度和80%的阴性预测值。Zulfiqar虚弱量表的曲线下面积(AUC)报告为0.8。
    结论:\"ZFS\"工具允许以非常令人满意的灵敏度和阴性预测值检测虚弱。
    BACKGROUND: The primary aim of the study was to validate the Zulfiqar Frailty Scale (ZFS) and examine its concordance with the modified Short Emergency Geriatric Assessment (mSEGA) scale, Part A.
    METHODS: A prospective observational study was conducted in Guadeloupe (France) over a two-month duration (from 20 February to 20 April 2024), involving elderly individuals aged 65 and older, deemed self-sufficient with an ADL (Activities of Daily Living) score exceeding four out of six.
    RESULTS: Within this community cohort of 98 individuals, averaging 75 years in age, frailty according to the modified SEGA criteria was prevalent in 29%. Frailty according to the \"ZFS\" score was prevalent in 40%. Key predictors of frailty identified in our study included age, comorbidity (Charlson score), polypharmacy (total number of medications and therapeutic classes), and functional ability (ADL scores). Notably, experiences of falls and hospitalizations within the past six months significantly influenced the classification of frailty according to both ZFS and SEGA scales. Significant associations with the presence of home care aides (p < 0.0001), monopodal support test results (p < 0.0001), memory impairments (p < 0.0001), and recent hospitalizations (p = 0.0054) underscored the multidimensional impact of frailty. The Pearson correlation coefficient and its 95% confidence interval between the SEGA and Zulfiqar Frailty Scales stood at 0.73 [0.61: 0.81]. The discernment threshold for frailty was set at three out of six criteria, showcasing a sensitivity of 64% and a negative predictive value of 80%. The area under the curve (AUC) for the Zulfiqar Frailty Scale was reported as 0.8.
    CONCLUSIONS: The \"ZFS\" tool allows for the detection of frailty with a highly satisfactory sensitivity and negative predictive value.
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  • 文章类型: Case Reports
    此病例报告详细介绍了一名88岁男子的诊断挑战和管理,该男子因败血症样症状出现在日本农村社区医院,根据他的物理和实验室检查结果,最初怀疑是急性细菌性胆管炎。尽管他唑巴坦和哌拉西林的抗生素治疗,病人的症状持续存在,导致进一步的调查显示,没有感染的迹象,但在对比增强的计算机断层扫描中,主动脉弓壁明显增厚。这些发现,结合患者的临床表现和缺乏抗生素反应,将诊断重定向到巨细胞动脉炎(GCA)。每天60mg泼尼松龙的给药可显著缓解症状并防止潜在的严重并发症,例如失明和不可逆的神经损伤。该病例强调了在出现全身炎症症状的老年患者中考虑GCA的重要性以及及时干预的必要性。它还强调了在老年患者中管理高剂量类固醇治疗的挑战,并提出了整合免疫抑制剂以减少类固醇依赖的潜在益处。本报告强调需要在GCA的非典型表现中提高意识和全面的诊断方法,特别是在资源有限的医疗保健环境中的老年人群中。
    This case report details the diagnostic challenge and management of an 88-year-old man who presented to a rural Japanese community hospital with sepsis-like symptoms, initially suspected of acute bacterial cholangitis based on his physical and laboratory findings. Despite the antibiotic treatment of tazobactam and piperacillin, the patient\'s symptoms persisted, leading to further investigations that revealed no signs of infection but notable aortic arch wall thickening on contrast-enhanced computed tomography scans. These findings, combined with the patient\'s clinical presentation and lack of antibiotic response, redirected the diagnosis toward giant cell arteritis (GCA). The administration of prednisolone of 60 mg daily significantly alleviated symptoms and prevented potential severe complications such as blindness and irreversible neurological damage. This case underscores the importance of considering GCA in elderly patients presenting with systemic inflammatory symptoms and the necessity of timely intervention. It also highlights the challenges in managing high-dose steroid therapy in elderly patients and suggests the potential benefits of integrating immunosuppressants to reduce steroid dependency. This report emphasizes the need for heightened awareness and a comprehensive diagnostic approach in atypical presentations of GCA, particularly in geriatric populations within resource-limited healthcare settings.
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  • 文章类型: Journal Article
    背景:全科医生和精神科医生之间有关于精神病诊断的过度诊断与漏报的讨论。对该主题的更深入了解对于提供合理的医疗保健和规划未来的研究至关重要。理解这一讨论的一个关键因素是每个部门疾病患病率的差异。获得有关此类流行情况的知识的一种方法是分析有关部门的常规护理数据。然而,与诊断相关的数据可能会受到其他几个影响因素的影响。
    目的:本研究旨在探讨在精神病和普通医疗环境中,什么样的动机和修饰因素在进行精神病诊断中起作用或反对作用。
    方法:对普通医学和精神病学领域的德国医生进行了26次半结构化访谈。使用内容分析对访谈进行了分析。
    结果:分析揭示了发现诊断的三个主要动机类别:(1)“客观事物”,例如“研究分类”;(2)“功能和性能相关因素”,例如“药物要求”,与某些诊断或“获得适当护理”相关的“帐单方面”和(3)“个人因素”,例如“医生的个性”。同样,出现了导致无法进行精神病诊断的因素,例如“患者对污名化的恐惧”或“精神病诊断的有害保险状况”。此外,参与者还提到了“未诊断精神病诊断”的其他原因,如“其他临床图片的编码”。
    结论:诊断过程是一个复杂的现象,远远超出了医学发现的识别。在处理和解释用于设计医疗保健系统或设计研究的次要数据时,应考虑这种见解。
    BACKGROUND: There is a discussion among general practitioners and psychiatrists regarding over-diagnosing versus under-reporting of psychiatric diagnoses. A deeper understanding of this topic is relevant for providing reasonable health care and for planning future studies. A crucial factor to understanding this discussion is the difference in the prevalence of a disease in each sector. One way to attain knowledge about such prevalences is the analysis of routine care data of the sector in question. However, diagnosis-related data might be modified by several additional influencing factors.
    OBJECTIVE: This study aims to explore what kind of motives and modifying factors play a role for or against giving psychiatric diagnoses in psychiatric and general medical settings.
    METHODS: Twenty-six semi-structured interviews were conducted with German physicians in the fields of general medicine and psychiatry. Interviews were analysed using content analysis.
    RESULTS: The analysis revealed three major motivational categories for finding a diagnosis: (1) \"objective matters\" such as \"categorisation for research\"; (2) \"functional and performance-related factors\" such as \"requirement for medication\", \"billing aspects\" that go with certain diagnoses or \"access to adequate care\" and (3) \"Individual factors\" such as the \"personality of a physician\". Similarly, factors emerged that lead to not making psychiatric diagnoses like \"fear of stigmatization among patients\" or \"detrimental insurance status with psychiatric diagnosis\". Additionally participants mentioned other reasons for \"not diagnosing a psychiatric diagnosis\", such as \"coding of other clinical pictures\".
    CONCLUSIONS: The diagnostic process is a complex phenomenon that goes far beyond the identification of medical findings. This insight should be considered when processing and interpreting secondary data for designing health care systems or designing a study.
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  • 文章类型: Journal Article
    这项研究提供了对日本农村地区母婴健康(MCH)的批判性叙述回顾,反映了全球老龄化社会面临的更广泛的挑战。这项研究探讨了专业和非专业护理在维持农村社区中的交织作用,强调家庭医学和初级保健在加强妇幼保健服务方面的独特地位。医疗资源的稀缺,特别是产科医生的短缺和传统社区支持系统的弱化,强调了这些领域的挑战。我们的审查方法涉及对PubMed进行全面搜索,以查找2000年4月至2024年8月发表的文章,重点是日本农村的MCH问题。这项研究强调了农村妇幼保健提供方面的几个关键差距:医疗专业人员向城市中心的迁移,影响传统护理的社会结构转型,以及初级保健医生缺乏专门的妇幼保健培训。我们讨论了潜在的解决方案,如激励农村地区的产科护理,将妇幼保健教育纳入家庭医学课程,和振兴社区支持系统。通过解决这些问题,这项研究旨在制定可行的策略来支持妇幼保健服务,从而确保日本农村社区和全球类似环境的健康结果和可持续性。
    This research provides a critical narrative review of maternal and child health (MCH) in rural Japan, reflecting broader challenges faced by aging societies globally. The study explores the intertwined roles of professional and lay care in sustaining rural communities, emphasizing the unique position of family medicine and primary care in enhancing MCH services. The scarcity of healthcare resources, particularly the shortage of obstetricians and the weakening of traditional community support systems, underscores the challenges in these areas. Our review method involved a comprehensive search of PubMed for articles published from April 2000 to August 2024, focusing on MCH issues in rural Japan. This study highlights several critical gaps in rural MCH provision: the migration of medical professionals to urban centers, the transformation of social structures affecting traditional caregiving, and the lack of specialized MCH training among primary care physicians. We discuss potential solutions such as incentivizing obstetric care in rural areas, integrating MCH education within family medicine curricula, and revitalizing community-based support systems. By addressing these issues, the research aims to formulate actionable strategies to bolster MCH services, thus ensuring better health outcomes and sustainability of rural communities in Japan and similar settings worldwide.
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  • 文章类型: English Abstract
    目的:本研究的目的是探讨全科医生对DSM-5成人ADHD自我报告筛查量表(ASRS-5)作为筛查工具的适用性的主观看法。一般实践中成人的注意力缺陷/多动障碍(ADHD)。
    方法:11名全科医生,我们采访了参加德语版ASRS-5验证研究的患者.为此,半结构化面试指南是使用实施研究综合框架(CFIR)设计的。采访是录音的,转录,并根据Kuckartz采用定性内容分析进行分析。
    结果:ASRS-5似乎在一般医学实践中效果良好。但是有证据表明,全科医生缺乏对成年人多动症的了解,并且需要在这一领域进行进一步培训。此外,在ADHD筛查阳性后,后续治疗的可能性不足.
    结论:在一般医学中,在临床疑似病例中引入ASRS-5筛查可能是改善成年ADHD患者治疗的第一步.
    结论:优化成人多动症的管理需要额外的信息和培训举措,以支持早期诊断,尤其是在初级保健环境中,并揭示成人多动症的治疗选择和护理理念。
    OBJECTIVE: The aim of the study was to explore the subjective views of general practitioners on the applicability of the Adult ADHD Self-Report Screening Scale for DSM-5 (ASRS-5) as a screening tool for attention-deficit/hyperactivity disorder (ADHD) in adults in general practice.
    METHODS: Eleven general practitioners, who had participated in the validation study of the German version of the ASRS-5, were interviewed. For this purpose, a semi-structured interview guide was designed using the Consolidated Framework for Implementation Research (CFIR). The interviews were audio-recorded, transcribed, and analyzed using qualitative content analysis according to Kuckartz.
    RESULTS: The ASRS-5 seems to work well in general medical practice. But there is evidence for a lack of knowledge about ADHD in adults among general practitioners and a demand for further training in this area. Moreover, insufficient possibilities for subsequent treatment after a positive ADHD screening were claimed.
    CONCLUSIONS: In general medicine, the introduction of a screening using ASRS-5 in cases of clinical suspicion could be the first step towards improving the management of adult patients with ADHD.
    CONCLUSIONS: Optimizing the management of adults with ADHD requires additional information and training initiatives to support early diagnosis especially in the primary care setting, and to reveal treatment options and care concepts for adults with ADHD.
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  • 文章类型: Case Reports
    老年人自身免疫性疾病的诊断,由于发热和全身疼痛等症状的不同病因,接受透析的免疫功能低下患者面临重大挑战。本案例研究报告了一名79岁的男性,患有多种合并症,包括糖尿病,心力衰竭,和纯红细胞再生障碍.他表现为亚急性多关节炎和发烧,最终被诊断为血清阴性的类风湿性关节炎。该病例说明了该人群鉴别诊断的复杂性,强调需要一种系统的方法来区分可能的感染和自身免疫原因。尽管没有类风湿因子和抗瓜氨酸蛋白抗体,患者的临床表现和对类固醇的反应支持血清阴性类风湿性关节炎的诊断。使用泼尼松龙治疗可显著改善症状和生活质量,证明类固醇在管理老年人自身免疫性疾病方面的有效性,高危患者。然而,由于潜在的不利影响,这种治疗需要仔细监测。该病例强调了在鉴别诊断中考虑自身免疫性疾病和定制治疗策略以适应老年人的独特需求的重要性。免疫功能低下的透析患者。这种情况下的见解有助于更好地理解和管理相似患者人群中的复杂临床情景。
    The diagnosis of autoimmune diseases in elderly, immunocompromised patients undergoing dialysis poses significant challenges due to the diverse etiology of symptoms such as fever and systemic pain. This case study reports on a 79-year-old man undergoing hemodialysis with a history of multiple comorbidities, including diabetes, heart failure, and pure red cell aplasia. He presented with subacute polyarthritis and fever and was ultimately diagnosed with seronegative rheumatoid arthritis. The case illustrates the complexities of differential diagnosis in this population, emphasizing the need for a systematic approach to distinguish between possible infectious and autoimmune causes. Despite the absence of rheumatoid factor and anti-citrullinated protein antibody, the patient\'s clinical presentation and response to steroids supported the diagnosis of seronegative rheumatoid arthritis. Treatment with prednisolone resulted in significant improvement in symptoms and quality of life, demonstrating the effectiveness of steroids in managing autoimmune conditions in elderly, high-risk patients. However, such treatment necessitates careful monitoring due to potential adverse effects. This case underlines the importance of considering autoimmune diseases in differential diagnoses and customizing treatment strategies to accommodate the unique needs of elderly, immunocompromised patients on dialysis. Insights from this case contribute to better understanding and management of complex clinical scenarios in similar patient populations.
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