大多数生物已经进化出特定的机制来响应环境条件的变化,例如白天的光和温度。生物体生理和行为的这些周期性变化,被称为昼夜节律,是转录和翻译反馈回路形式的复杂分子机制的结果。植物昼夜节律调节网络是一个复杂的网络,包括各种转录因子,如CCA1,LHY,PRR,TOC1LUX,ELF3、ELF4、RVE8等。该网络使植物能够在不同的环境条件下适应和茁壮成长。它响应夹带信号,包括光,温度,和营养浓度,并与大多数生理功能如开花相互作用,生长和应激反应。这些基因调控网络的数学模型不仅可以更深入地了解功能,还可以了解随着气候变化而可能影响植物生长和功能的扰动。多年来,已经开发了许多数学模型来了解植物昼夜节律调节的各个方面。在这次审查中,我们深入研究了这些模型的系统开发,概述模型组件和随时间的改进。我们还强调了迄今为止开发的每个模型的优势和局限性。最后,我们通过描述这些模型的研究和发展的前景,以更好地理解植物昼夜节律调节。
Most organisms have evolved specific mechanisms to respond to changes in environmental conditions such as light and temperature over the course of day. These periodic changes in the physiology and behaviour of organisms, referred to as circadian rhythms, are a consequence of intricate molecular mechanisms in the form of transcription and translational feedback loops. The plant circadian regulatory network is a complex web of interconnected feedback loops involving various transcription factors such as CCA1, LHY, PRRs, TOC1, LUX, ELF3, ELF4, RVE8, and more. This network enables plants to adapt and thrive in diverse environmental conditions. It responds to entrainment signals, including light, temperature, and nutrient concentrations and interacts with most of the physiological functions such as flowering, growth and stress response. Mathematical modelling of these gene regulatory networks enables a deeper understanding of not only the function but also the perturbations that may affect the plant growth and function with changing climate. Over the years, numerous mathematical models have been developed to understand the diverse aspects of plant circadian regulation. In this review, we have delved into the systematic development of these models, outlining the model components and refinements over time. We have also highlighted strengths and limitations of each of the models developed so far. Finally, we conclude the review by describing the prospects for investigation and advancement of these models for better understanding of plant circadian regulation.