背景:高胆红素血症是新生儿常见的疾病,早产儿患这种疾病的风险更高。
目的:应用葡萄糖-6-磷酸脱氢酶(G6PD)基因检测,确定遵义地区新生儿高胆红素血症G6PD缺乏的发生率,分析G6PD缺乏的病因,为临床诊断和治疗提供科学依据。
方法:对于基因检测,选取64例高胆红素血症患儿作为观察组,选取30例正常新生儿作为对照组,采用多因素logistic回归分析探讨高胆红素血症的危险因素。
结果:观察组新生儿中,G1388A突变59例(92.19%),G1376T突变5例(7.81%)。对照组未检测到突变。在观察组中,早产新生儿的比例,人工喂养,随着开始喂食超过24小时的年龄,第一次排便时间超过24小时,胎膜早破,感染,头皮血肿,围产期窒息率高于对照组,差异有统计学意义(p<0.05)。多因素Logistic回归分析显示,感染,头皮血肿,围产期窒息,开始喂养超过24小时的年龄,首次排便时间超过24h是新生儿高胆红素血症发生的危险因素(p<0.05)。
结论:G1338A和G1376T突变是新生儿高胆红素血症遗传学的重要特征,和基因检测以及预防早产,感染,头皮血肿,围产期窒息,开始进食的年龄,第一次排便的时间将有助于减少这种疾病的发病率。
UNASSIGNED: Hyperbilirubinemia is a common disorder in neonates, with premature infants at higher risk of developing the disorder.
UNASSIGNED: Glucose-6-phosphate dehydrogenase (G6PD) gene detection was used to determine the incidence of G6PD deficiency and analyze the etiologies of G6PD deficiency in neonates with hyperbilirubinemia in the Zunyi region with the aim of providing scientific evidence for the clinical diagnosis and treatment.
UNASSIGNED: For the gene detection, 64 neonates with hyperbilirubinemia were selected as the observation group and 30 normal neonates were selected as the control group, and the risk factors for hyperbilirubinemia were investigated by using multivariate logistic regression analysis.
UNASSIGNED: Among the neonates in the observation group, 59 cases had the G1388A mutation (92.19%) and 5 cases had the G1376T mutation (7.81%). No mutation was detected in the control group. In the observation group, the proportion of neonates who were born prematurely, with artificial feeding, with the age of starting feeding of more than 24 h, the time of first bowel movement of more than 24 h, premature rupture of membranes, infection, scalp hematoma, and perinatal asphyxia was higher than that in the control group, and the difference was statistically significant (p< 0.05). Multivariate logistic regression analysis showed that prematurity, infection, scalp hematoma, perinatal asphyxia, the age of starting feeding of more than 24 h, and the time of first bowel movement over 24 h were risk factors for the development of neonatal hyperbilirubinemia (p< 0.05).
UNASSIGNED: The G1338A and G1376T mutations were important features of the genetics of neonatal hyperbilirubinemia, and genetic detection together with the prevention of prematurity, infection, scalp hematoma, perinatal asphyxia, the age of starting feeding, and the time of first bowel movement would help reduce the incidence of this disease.