gastric ulcer perforation

胃溃疡穿孔
  • 文章类型: Case Reports
    嗜酸性粒细胞性胃炎是一种罕见的嗜酸性粒细胞性胃肠道疾病。嗜酸性粒细胞性胃炎患者通常表现为恶心等症状,呕吐,腹痛,和减肥。在严重的情况下,患者可能会出现罕见的并发症,如胃出口梗阻和自发性穿孔。这里,我们介绍了一个年轻的成年男性,他出现急性腹痛1天。患者腹部CT扫描发现胃窦壁明显增厚伴气腹,与胃溃疡穿孔一致。患者接受了剖腹探查术,需要改良的格雷厄姆补片修复术。依据术中内镜活检标本的病理检讨作出嗜酸性粒细胞性胃炎的诊断。
    Eosinophilic gastritis is a rare type of eosinophilic gastrointestinal diseases. Patients with eosinophilic gastritis usually present with symptoms such as nausea, emesis, abdominal pain, and weight loss. In severe cases, patients can suffer rare complications such as gastric outlet obstruction and spontaneous perforation. Here, we present the case of a young adult male who presented with acute onset abdominal pain for 1 day. The patient was found to have significant mural thickening of gastric antrum with pneumoperitoneum on abdominal CT scan, consistent with a perforated gastric ulcer. The patient underwent exploratory laparotomy and required modified graham patch repair. The diagnosis of eosinophilic gastritis was made based on the pathology review of intraoperative endoscopic biopsy specimens.
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  • 文章类型: Observational Study
    背景:穿孔性消化性溃疡仍然是印度最常见的外科急症之一,具有显著的发病率和死亡率。这项研究的目的是确定影响消化性溃疡穿孔患者术后发病率和死亡率的围手术期危险因素。
    方法:这项观察性回顾性研究包括了在过去8年中在我们机构接受穿孔性消化性溃疡手术的500名患者。他们的临床表现,对围手术期管理进行了研究和分析。
    结果:共分析了500例病例,其中96%为男性。平均年龄为46.5岁。共有160例患者出现十二指肠穿孔,328例出现胃穿孔,平均大小为8.6mm。大多数患者(96.2%)接受了穿孔的网膜补片闭合,平均住院时间为14天。最常见的主要和次要术后并发症分别是插管时间延长和肺部不适。术后渗漏率为5.8%的病例中有6.2%需要重新检查。年龄>60岁,共病的存在,术前休克和穿孔大小>1cm被确定为术后发病率的独立预测因子.总死亡率为11.6%,而男性和女性的特定死亡率分别为11.8%和5%。年龄>60岁,演示时感到震惊,腹部强直和穿孔大小>1cm是死亡率的独立预测因素.
    结论:老年,合并症,演示时感到震惊,穿孔尺寸>1厘米,较高的ASA等级,手术时间延长和胆红素污染>500mL是术后发病率和死亡率增加的独立预测因素.
    BACKGROUND: Perforated peptic ulcer remains one of the most common surgical emergencies in India with significant morbidity and mortality. The aim of this study was to identify the perioperative risk factors influencing the post-operative morbidity and mortality in patients with perforated peptic ulcer disease.
    METHODS: Five-hundred patients who underwent surgery for perforated peptic ulcer in our institution in the preceding 8 years were included in this observational retrospective study. Their clinical presentations, peri-operative managements were studied and analysed.
    RESULTS: Five hundred cases were analysed of which 96% were males. Mean age was 46.5 years. A total of 160 patients had duodenal perforation and 328 had gastric perforation with a mean size of 8.6 mm. Most patients (96.2%) underwent omental patch closure of the perforation with mean length of hospitalization being 14 days. The most common major and minor postoperative complications were prolonged intubation and pulmonary complaints respectively. Re-exploration was needed in 6.2% of cases with a post-operative leak rate of 5.8%. Age >60 years, presence of comorbid illnesses, shock at presentation and perforation size >1 cm were identified as independent predictors of postoperative morbidity. Overall mortality was 11.6% while specific mortality among males and females were 11.8% and 5% respectively. Age >60 years, shock at presentation, presence of abdominal rigidity and size of perforation >1 cm were independent predictors of mortality.
    CONCLUSIONS: Old age, comorbidities, shock at presentation, perforation size >1 cm, higher ASA grade, prolonged surgery and biliopurulent contamination >500 mL were independent predictors of both increased post-operative morbidity and mortality.
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  • 文章类型: Case Reports
    慢性淋巴细胞白血病(CLL)是一种恶性肿瘤,其特征是淋巴细胞在骨髓和淋巴器官中的进行性积累。胃肠道表现在所有类型的白血病中都很少见。一般来说,这种情况发生在复发性疾病或急性白血病中;然而,最近的治疗进展减少了这些并发症。最常见的是,胃中的病变是出血性的,和下胃肠道的病变表现为腹膜炎或结肠炎。我们的病人是独一无二的,因为她有穿孔,而不是流血,开始伊布替尼后由浸润性慢性淋巴细胞白血病引起的消化性溃疡。虽然这种药物会损害伤口愈合和/或导致出血,目前尚无溃疡穿孔的报告。此外,慢性淋巴细胞白血病引起消化性溃疡穿孔(PUD)是罕见的,这就是,根据我们的知识,这种现象的第一个例子。
    Chronic lymphocytic leukemia (CLL) is a malignancy characterized by the progressive accumulation of lymphocytes in the bone marrow and lymphoid organs. Gastrointestinal manifestations are rare in all types of leukemia. Generally, this occurs during relapsing disease or in acute leukemias; however, recent advancements in treatment have reduced these complications. Most commonly, lesions in the stomach are hemorrhagic, and lesions in the lower gastrointestinal tract present as peritonitis or colitis. Our patient was unique because she had a perforated, rather than bleeding, peptic ulcer caused by infiltrative chronic lymphocytic leukemia after starting ibrutinib. Although this medication can impair wound healing and/or cause bleeding, there are no reports of perforation of existing ulcers. Additionally, chronic lymphocytic leukemia causing perforated peptic ulcer disease (PUD) is rare, and this is, to our knowledge, the first case of this phenomenon.
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  • 文章类型: Case Reports
    介绍消化性溃疡通常以急腹症的形式出现在紧急情况下,通常在临床或放射学上容易诊断。尽管其发病率随着质子泵抑制剂的引入而降低,但仍然是外科医生遇到的最常见的紧急情况之一。病例介绍一名60岁的妇女抱怨上腹部肿胀6个月,在过去2个月中逐渐增加并变得不可减少。患者还抱怨与呕吐相关的疼痛。放射学检查显示上腹部疝,网膜和胃为内容物,并在右肝周区域收集液体,微小的空气焦点。对患者进行了调查。讨论穿孔性消化性溃疡是一种严重的并发症,具有很高的发病和死亡风险。早期诊断,立即复苏和手术干预对于改善预后至关重要。这是一例罕见的穿孔性胃溃疡,在复杂的腹疝下被掩盖。
    Introduction  Peptic ulcer usually presents to the emergency in the form of an acute abdomen, which is usually diagnosed easily either clinically or radiologically. Although its incidence has decreased with the introduction on proton pump inhibitors it is still one of the most common emergencies encountered by a surgeon. Case Presentation  A 60-year-old woman complained of epigastric swelling for 6 months which gradually increased and became irreducible over the last 2 months. The patient also complained of pain associated with vomiting. Radiological investigations revealed a epigastric hernia with omentum and stomach as content along with fluid collection in the right perihepatic region, with tiny air foci. The patient was explored for the same. Discussion  Perforated peptic ulcer is a serious complication and carries high risk of morbidity and mortality. Early diagnosis with immediate resuscitation and surgical intervention is essential to improve outcomes. This is a rare case of perforated gastric ulcer which was masked under the complicated ventral hernia.
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  • 文章类型: Case Reports
    Diaphragmatic hernia in adults often presents with overlapping respiratory and abdominal symptoms. They may be simple diaphragmatic eventrations or undiagnosed Bochdalek\'s hernias or may even be of post traumatic variety. Diaphragmatic hernias may be asymptomatic, present only with respiratory symptoms, or may present with obstruction and strangulation of involved bowel loops with faeco-pneumothorax. The index case was operated for open diaphragmatic hernia repair six years back and admitted for breathlessness with absence of abdominal signs and symptoms. Patient subsequently developed hydro-pneumothorax during conservative management. Emergency laparotomy revealed a gastric ulcer which perforated into the left chest giving rise to hydro-pneumothorax. In present study we would like to report how this unusual presentation led to dilemma in diagnosis and surgical intervention thus increasing the morbidity and mortality of the patient at our institute.
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