■主要目的是建立液体胃排空和小肠的参考值。次要目标包括比较前视图和几何平均方法,评估性别差异,并探索与年龄的潜在相关性。
■连续35名健康参与者(28名女性和7名男性),平均年龄为42±11岁(中位数,42;范围,23-65)以五个间隔(0、0.5、1、2和4h)进行液体胃排空闪烁显像,在24小时进行可选的额外成像。使用保留百分比和半衰期(T1/2)评估液体胃排空。使用小肠转运指数(ISBT)评估小肠转运,计算为4小时时回肠末端储库计数与总腹部计数的比率。参考值基于百分位数或平均值和标准偏差(SD)建立。通过目视检查确定快速小肠运输。统计分析涉及配对样本t检验或Wilcoxon符号秩检验,以比较成像方法。性别比较的独立样本t检验或曼-惠特尼U检验,和Spearman的等级相关性,用于评估与年龄相关的协会。双尾P<0.05表示显著性。
■基于几何平均方法的快速液体胃排空定义为在30分钟时保留百分比<8%,当延迟排空时,保留百分比>33%,>20%,在1、2和4小时时>4%,分别。胃排空的T1/2参考范围为10-60分钟。用几何平均法确定小肠转运参考值为4h时ISBT>30%,而快速小肠运输被定义为1小时内盲肠升结肠活动的首次可视化。与几何平均方法相比,前视方法的液体胃排空和小肠运输参数明显更高(P≤0.019),除了2小时的保留百分比(P=0.510)。然而,获得的参考值,无论是基于百分位数还是平均值和SD,两种方法之间没有显着差异,以保证临床意义。性别对液体胃排空或小肠转运均无影响(P≥0.173),和年龄没有显著的中度或强烈相关性(斯皮尔曼ρ≤0.397)。
■该研究通过标准胃排空闪烁显像方案确定了液体胃排空和小肠转运的参考值,避免额外的复杂程序或延长成像会话。已建立的规范数据可适用于年龄≥18岁的男女个体。在提倡几何平均法作为首要选择的同时,该研究承认,在资源有限的繁忙中心处理多项研究,并且单头伽马相机迎合多项研究,前视方法仍然是一个可行的选择。
UNASSIGNED: The primary objective was to establish the reference values for liquid gastric emptying and small bowel. The secondary objectives encompassed comparing the anterior view and geometric mean methods, assessing gender differences, and exploring potential correlations with age.
UNASSIGNED: Thirty-five consecutive healthy participants (28 females and 7 males) with a mean age of 42 ± 11 years (median, 42; range, 23-65) underwent liquid gastric emptying scintigraphy at five intervals (0, 0.5, 1, 2, and 4 h), with optional additional imaging at 24 h. Liquid gastric emptying was evaluated using percent retention and half-time (T1/2). Small-bowel transit was assessed using the index of small-bowel transit (ISBT), calculated as the ratio of terminal ileal reservoir counts to total abdominal counts at 4 h. Reference values were established based on percentiles or mean and standard deviation (SD). Rapid small-bowel transit was determined through visual inspection. Statistical analysis involved paired Samples t-test or Wilcoxon signed-rank test for comparing imaging methods, independent Samples t-test or Mann-Whitney U-test for gender comparison, and Spearman\'s rank correlation for assessing age-related associations. A 2-tailed P < 0.05 indicated significance.
UNASSIGNED: Rapid liquid gastric emptying based on the geometric mean method was defined as percent retention <8% at 30 min, while delayed emptying as percent retention >33%, >20%, and >4% at 1, 2, and 4 h, respectively. The reference range of T1/2 of gastric emptying was 10-60 min. The reference value for small-bowel transit using the geometric mean method was established as ISBT >30% at 4 h, while rapid small-bowel transit was defined as the first visualization of activity in the cecum-ascending colon within 1 h. Parameters for liquid gastric emptying and small-bowel transit were notably higher in the anterior view method compared to the geometric mean method (P ≤ 0.019), except for percent retention at 2 h (P = 0.510). Nevertheless, the obtained reference values, whether based on percentiles or mean and SD, showed no notable variance between the two methods to warrant clinical significance. Gender did not display an impact on liquid gastric emptying or small-bowel transit in either method (P ≥ 0.173), and age demonstrated no significant moderate or strong correlations (Spearman\'s ρ ≤ 0.397).
UNASSIGNED: The study determined reference values for liquid gastric emptying and small-bowel transit through a standard gastric emptying scintigraphy protocol, avoiding additional complex procedures or extended imaging sessions. The established normative data can apply to individuals of both genders aged ≥18 years. While advocating the geometric mean method as the primary choice, the study acknowledges that in busy centers handling multiple studies with limited resources and a single-head gamma camera catering to multiple studies, the anterior view method remains a feasible alternative.