背景:叔丁基苯酚(TBP)衍生物,粘合剂和糖尿病装置中的抗氧化剂,可能引发过敏性接触性皮炎(ACD)。
目的:本研究的目的是报告医疗器械中TBP衍生物的致敏作用,并强调叔丁基对苯二酚(BHQ)和叔丁基邻苯二酚(TBC)是这方面的潜在筛选剂。
方法:对来自粘合剂和糖尿病设备的15例ACD患者进行了不同TBP的贴片测试:BHQ1%pet。,TBC0.25%宠物。,BHA2%宠物。,BHT2%宠物。,4-叔丁基苯酚(TBP)1%pet。和2,4-二叔丁基苯酚(diTBP)1%pet。罪魁祸首装置(医用粘合剂,卫生垫,糖尿病设备)和TBP贴片制剂使用气相色谱-质谱(GC-MS)进行分析。
结果:BHQ(9/13),TBC(7/13),和较小程度的BHT(3/15),BHA(2/15)和TBP(2/13)产生阳性反应。七名患者从粘合剂和糖尿病装置中产生了ACD,分别,和一名卫生巾患者。GC-MS分析医疗器械和贴片试验材料证实了贴片试验阳性TBP的存在,或化学相关的衍生物,或者,有趣的是,发现叔丁基苯醌(BBQ),也就是说,自发形成的,高反应性TBP代谢物,可能(伪)与补丁测试的TBP交叉反应。
结论:TBP可能是医疗器械中被忽视的敏化剂,BHQ和TBC在这方面是潜在的筛查人员。
BACKGROUND: Tert-butylphenol (TBP) derivatives, antioxidants in adhesives and diabetes devices, may provoke allergic contact dermatitis (ACD).
OBJECTIVE: The objective of this study is to report sensitization to TBP derivatives in medical devices and to highlight that tert-butylhydroquinone (BHQ) and tert-butylcatechol (TBC) are potential screeners in this regard.
METHODS: Fifteen patients with ACD from adhesives and diabetes devices were patch tested to different TBPs: BHQ 1% pet., TBC 0.25% pet., BHA 2% pet., BHT 2% pet., 4-tert-butylphenol (TBP) 1% pet. and 2,4-di-tert-butylphenol (di TBP) 1% pet. The culprit devices (medical adhesives, sanitary pads, diabetes devices) and TBP patch preparations were analysed using gas chromatography-mass spectrometry (GC-MS).
RESULTS: BHQ (9/13), TBC (7/13), and to a lesser extent BHT (3/15), BHA (2/15) and TBP (2/13) gave positive reactions. Seven patients had developed ACD from adhesives and diabetes devices, respectively, and one patient from sanitary pads. GC-MS analyses of the medical devices and patch test materials confirmed the presence of the patch-test positive TBPs, or chemically related derivatives, or, interestingly, tert-butylbenzoquinones (BBQ) were found, that is, spontaneously formed, highly reactive TBP metabolites, likely (pseudo-) cross reacting with the patch tested TBPs.
CONCLUSIONS: TBPs might be overlooked sensitizers in medical devices, and BHQ and TBC are potential screeners in this regard.