■静息状态功能磁共振成像数据的动态功能网络连接(dFNC)分析已对许多神经系统和神经精神疾病产生了见解。常见的dFNC分析方法使用k均值聚类等硬聚类方法将样本分配给总结网络动态的状态。然而,硬聚类方法通过假设(1)集群中的所有样本都与它们分配的质心相同,并且(2)在数据空间中彼此比它们的质心更接近的样本由它们的质心很好地表示来掩盖网络动态。此外,很难比较科目,因为在某些情况下,个人可能没有表现出足够强的状态来进入硬集群。允许对连接模式进行维度处理的方法(例如,模糊聚类)可以缓解这些问题。在这项研究中,我们提出了一个可解释的模糊聚类框架,通过结合模糊c均值聚类与几个可解释性指标和新的摘要特征。
■我们将我们的框架应用于精神分裂症(SZ)默认模式网络分析。即,我们从具有SZ和对照的个体中提取DFNC,识别5个dFNC状态,并使用新的基于扰动的聚类可解释性方法来表征对这些状态最重要的dFNC特征。然后,我们提取了通常用于硬聚类的几个特征,并进一步呈现了专门设计用于模糊聚类的各种独特特征,以量化状态动态。我们研究了具有SZ和对照的个体之间这些特征的差异,并进一步搜索这些特征与SZ症状严重程度之间的关系。
■重要的是,我们发现,患有SZ的个体花费更多的时间在前后扣带回皮质之间处于中度反相关状态,而在前突和前扣带回皮质之间处于强烈的反相关状态。我们进一步发现,具有SZ的个体倾向于在低幅度和高幅度dFNC状态之间比对照更快地转变。
■我们提出了一种新颖的dFNC分析框架,并用它来识别SZ对网络动力学的影响。鉴于我们的框架易于实施及其对网络动态的增强洞察力,它在未来的DFNC研究中具有很大的应用潜力。
UNASSIGNED: Dynamic functional network connectivity (dFNC) analysis of resting state functional magnetic resonance imaging data has yielded insights into many neurological and neuropsychiatric disorders. A common dFNC analysis approach uses hard clustering methods like k-means clustering to assign samples to states that summarize network dynamics. However, hard clustering methods obscure network dynamics by assuming (1) that all samples within a cluster are equally like their assigned centroids and (2) that samples closer to one another in the data space than to their centroids are well-represented by their centroids. In addition, it can be hard to compare subjects, as in some cases an individual may not manifest a state strongly enough to enter a hard cluster. Approaches that allow a dimensional approach to connectivity patterns (e.g., fuzzy clustering) can mitigate these issues. In this study, we present an explainable fuzzy clustering framework by combining fuzzy c-means clustering with several explainability metrics and novel summary features.
UNASSIGNED: We apply our framework for schizophrenia (SZ) default mode network analysis. Namely, we extract dFNC from individuals with SZ and controls, identify 5 dFNC states, and characterize the dFNC features most crucial to those states with a new perturbation-based clustering explainability approach. We then extract several features typically used in hard clustering and further present a variety of unique features specially designed for use with fuzzy clustering to quantify state dynamics. We examine differences in those features between individuals with SZ and controls and further search for relationships between those features and SZ symptom severity.
UNASSIGNED: Importantly, we find that individuals with SZ spend more time in states of moderate anticorrelation between the anterior and posterior cingulate cortices and strong anticorrelation between the precuneus and anterior cingulate cortex. We further find that individuals with SZ tend to transition more rapidly than controls between low-magnitude and high-magnitude dFNC states.
UNASSIGNED: We present a novel dFNC analysis framework and use it to identify effects of SZ upon network dynamics. Given the ease of implementing our framework and its enhanced insight into network dynamics, it has great potential for use in future dFNC studies.