目的:本研究的目的是确定Fuchs内皮角膜营养不良(FECD)研究领域的趋势和重点。
方法:进行了基于WebofScienceCoreCollection的文献计量分析。提取并分析了2001年至2020年与FECD有关的所有出版物。VOSviewerv.1.6.17用于构建可视化地图,并评估FECD研究的趋势和重点。
结果:共提取了1,041篇出版物。全球出版物的比率稳步上升。美国的出版物数量最高(461),引用次数最多(18,757次),H指数最高(69)。MellesGRJ发表的论文数量最多(60),在FECD研究领域,PriceFW的引用次数最多(4,154次)。出版物数量最多的是《角膜》杂志(279)。关键词分为四类:(1)角膜移植手术,(2)手术技术和器械,(3)角膜参数测量,(4)遗传和分子病理机制。对关键词的平均出现年份(AAYs)进行了评估。最近出现的关键词包括“Tcf4基因”(2018.3年的AAY),\"ctg18.1\"(AYof2017.2),“三核苷酸重复扩展”(2018.3年的AAY),“岩石抑制剂”(2017.4年AY),和“decesemetorhexis”(AYof2017.4)。
结论:美国在FECD研究中占据主导地位。尽管角膜移植手术长期以来一直是FECD研究领域的最主流领域,基因突变,如TCF4CTG三核苷酸重复扩增,非手术干预措施,如rho相关激酶抑制剂,较新的手术方法如无内皮角膜移植术是潜在的研究热点。
OBJECTIVE: The aim of this study was to identify trends and focuses in the field of Fuchs endothelial corneal dystrophy (FECD) research.
METHODS: A bibliometric analysis based on the Web of Science Core Collection was conducted. All publications related to FECD from 2001 to 2020 were extracted and analyzed. VOSviewer v.1.6.17 was used to construct a visualization map and evaluate the trends and focuses in FECD research.
RESULTS: A total of 1,041 publications were extracted. The rate of global publications has steadily increased. The United States produced the highest number of publications (461), the highest number of citations (18,757), and the highest H index (69). Melles GRJ published the highest number of papers (60), and Price FW had the highest number of citations (4,154) in the FECD research field. The highest number of publications came from the journal Cornea (279). Keywords were classified into four clusters: (1) corneal transplantation surgery, (2) surgical techniques and instruments, (3) corneal parameter measurement, and (4) genetic and molecular pathomechanisms. The average appearing years (AAYs) of the keywords were evaluated. Recently appearing keywords included \"Tcf4 gene\" (AAY of 2018.3), \"ctg18.1\" (AAY of 2017.2), \"trinucleotide repeat expansion\" (AAY of 2018.3), \"rock inhibitor\" (AAY of 2017.4), and \"descemetorhexis\" (AAY of 2017.4).
CONCLUSIONS: The United States has a dominant position in FECD research. Although corneal transplantation surgery has been the most mainstream area of FECD research field for a long time, gene mutations such as the TCF4 CTG trinucleotide repeat expansion, nonsurgical interventions such as rho-associated kinase inhibitors, and newer surgical methods such as descemetorhexis without endothelial keratoplasty are potential research hotspots.