这项研究的目的是评估的效用的氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描(FPCT)参数检测复发性疾病和抢救手术的结果在多模式治疗后局部晚期口腔鳞状细胞癌(TSCC)。总的来说,69例局部晚期TSCC患者接受多模式治疗。所有患者在初次手术后4-10个月接受全身FPCT扫描。分析包括FPCT参数,例如最大标准化摄取值(SUVmax),代谢性肿瘤体积(MTV),和总病变糖酵解(TLG)。组织学检查用作参考标准。复发性TSCC患者接受抢救手术或手术加全身治疗。这项研究包括69例患者:复发TSCC组36例,非复发TSCC组33例。SUVmax,MTV,TSCC复发组TLG分别为11.3±3.6,28.3±15.6cm3和113.2±46.8g,分别为5.9±3.6、5.1±2.2cm3和13.4±4.8g,分别在非复发性TSCC组中。两组在SUVmax方面有显著差异,MTV,和TLG。在复发性TSCC组中,91.6%的患者出现了当地,局部区域,和区域性疾病,并接受了抢救手术和系统治疗,而仅有远处转移的局部区域复发为8.4%,并接受了手术加全身治疗.术后随访12~60个月;复发和非复发TSCC组19例和20例患者均无疾病证据。而11和8人患有这种疾病。局部复发或远处转移导致复发TSCC组6例死亡,非复发TSCC组5例死亡。两组之间的生存率没有显着差异。FPCT参数可以检测多模式治疗后局部晚期TSCC的复发。早期抢救手术可以改善复发性TSCC的治疗效果。
The purpose of this study was to evaluate the utility of ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (FPCT) parameters for detecting recurrent disease and the outcomes of salvage surgery in patients with locally advanced oral tongue squamous cell carcinoma (TSCC) after multimodal treatment. In total, 69 patients with locally advanced TSCC were treated with multimodal therapy. All patients underwent whole-body FPCT scans 4-10 months after the initial surgery. The analysis included FPCT parameters, such as maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). Histological examination was used as the reference standard. Patients with recurrent TSCC underwent salvage surgery or surgery plus systemic treatment. This study included 69 patients: 36 in the recurrent TSCC group and 33 in the non-recurrent TSCC group. The SUVmax, MTV, and TLG in the recurrent TSCC group were 11.3 ± 3.6, 28.3 ± 15.6 cm3, and 113.2 ± 46.8 g, respectively; these values were 5.9 ± 3.6, 5.1 ± 2.2 cm3, and 13.4 ± 4.8 g, in the non-recurrent TSCC group respectively. The two groups had significant differences in terms of SUVmax, MTV, and TLG. In the recurrent TSCC group, 91.6 % of patients presented with local, locoregional, and regional disease and underwent salvage surgery plus systemic therapy, whereas 8.4 % had locoregional recurrence with distant metastases alone and underwent surgery plus systemic therapy. The patients were followed up for 12-60 months; 19 and 20 patients in the recurrent and non-recurrent TSCC groups showed no evidence of disease, whereas 11 and 8 were alive with the disease. Local recurrence or distant metastases led to the deaths of six patients in the recurrent TSCC group and five in the non-recurrent TSCC group. No significant differences in survival were observed between the two groups. FPCT parameters can detect the recurrence of locally advanced TSCC after multimodal treatment. Early salvage surgery can improve the treatment outcomes for recurrent TSCC.