目的:系统评价盐酸氟桂利嗪联合中药汤剂治疗偏头痛的疗效和优越性。
方法:作者对研究盐酸氟桂利嗪与中草药汤联合治疗偏头痛的临床随机对照试验(RCT)进行了全面搜索。搜索的数据库包括CNKI,VIP,万方,PubMed,WOI,科克伦图书馆,和Embase,涵盖2019年1月1日至2023年11月10日期间。两名独立研究人员精心筛选,提取,并评估了相关数据,采用Revman5.3软件进行荟萃分析。
结果:荟萃分析显示,与分离中使用的盐酸氟桂利嗪相比,与中药汤剂联合使用显着提高了有效率(RR=1.26,95%CI[1.18,1.34],p<0.0001)。此外,中医症状评分显著改善(MD=4.97,95%CI[-6.74,-3.19],p<0.00001)。与对照组相比,观察组内皮素水平有统计学上的显着改善(I2=85%,MD=-13.66,95%CI[-17.87,-9.45],p=0.0001)。观察组NRS评分较对照组明显降低,表明更好的结果(I2=95%,MD=-2.11,95%CI[-3.09,-1.12],p<0.0001)。观察组在减少发作次数方面优于对照组(I2=63%,MD=-1.16,95%CI[-1.45,-0.87],p=0.007)。
结论:盐酸氟桂利嗪与中药汤剂合用治疗偏头痛患者,与单用盐酸氟桂利嗪相比,临床疗效显著,中医症状积分改善明显。
To systematically evaluate the efficacy and superiority of Flunarizine Hydrochloride when combined with Traditional Chinese Medicine (TCM) Decoctions in treating migraine headaches.
The authors conducted a comprehensive search for clinical Randomized Controlled Trials (RCTs) investigating the combination of Flunarizine Hydrochloride with Chinese herbal decoctions in treating migraines. The databases searched included CNKI, VIP, Wanfang, PubMed, WOI, Cochrane Library, and Embase, covering the period from January 1, 2019, to November 10, 2023. Two independent researchers meticulously screened, extracted, and assessed the relevant data, employing the Revman 5.3 software for meta-analysis.
The meta-analysis revealed that, in comparison to Flunarizine Hydrochloride used in isolation, the combination with Chinese herbal decoctions markedly enhanced the effective rate (RR = 1.26, 95 % CI [1.18, 1.34], p < 0.0001). Moreover, significant improvements were observed in the TCM symptom score (MD = 4.97, 95 % CI [-6.74, -3.19], p < 0.00001). The observation group demonstrated a statistically significant improvement in endothelin levels compared to the control group (I2 = 85 %, MD = -13.66, 95 % CI [-17.87, -9.45], p = 0.0001). The observation group showed a significant reduction in NRS scores compared to the control group, indicating better outcomes (I2 = 95 %, MD = -2.11, 95 % CI [-3.09, -1.12], p < 0.0001). The observation group was superior to the control group in terms of the reduction in the number of episodes (I2 = 63 %, MD = -1.16, 95 % CI [-1.45, -0.87], p = 0.007).
The confluence of Flunarizine Hydrochloride with traditional Chinese medicine decoctions in treating migraine patients demonstrated substantial clinical efficacy and improvement in TCM symptom score over the use of Flunarizine Hydrochloride alone.