代谢物3-羧基-4-甲基-5-丙基-2-呋喃丙酸(CMPF)是脂肪鱼摄入的生物标志物。我们调查了CMPF的血浆水平与牙龈炎症和牙周炎病例定义之间的关系,以及范围和严重性变量。
马尔默后代研究是一项基于人群的研究,马尔默后代牙科研究(MODS)是它的牙科手臂,包括牙周图.使用液相色谱-质谱法测量血浆CMPF,并使用多变量线性或逻辑回归模型调整年龄,研究与牙周诊断和参数的关系。性别,教育,身体质量指数,空腹血糖,和吸烟。
有922名MODS参与者的代谢物数据。较高的CMPF水平与较少的牙龈炎症(β=-2.12,p=0.002)和较低的严重牙周炎几率(比值比[OR]=0.74,95%置信区间[CI]:0.56至0.98)相关。更高的CMPF水平也与更多的牙齿相关(β=0.19,p=0.001),牙周袋数量较低(≥4mm)(β=-1.07,p=0.007),在完全调整的模型中,两个或多个≥6mm牙周袋的几率较低(OR=0.80,95%CI:0.65至0.98)。
CMPF,脂肪鱼消费的有效生物标志物,与较少的牙周炎症和牙周炎有关。不能排除残留的混杂因素,和未来的研究是有必要的。
The metabolite 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF) is a fatty fish-intake biomarker. We investigated the association between plasma levels of CMPF in relation to gingival inflammation and periodontitis case definition, as well as the extent and severity variables.
The Malmö Offspring Study is a population-based study, and the Malmö Offspring Dental Study (MODS) is its dental arm, including periodontal charting. Plasma CMPF was measured using liquid chromatography-mass spectrometry and studied in relation to periodontal diagnosis and parameters using multivariable linear or logistic regression modelling adjusting for age, sex, education, body mass index, fasting glucose, and smoking.
Metabolite data were available for 922 MODS participants. Higher CMPF levels were associated with less gingival inflammation (β = -2.12, p = .002) and lower odds of severe periodontitis (odds ratio [OR] = 0.74, 95% confidence interval [CI]: 0.56 to 0.98). Higher CMPF levels were also associated with more teeth (β = 0.19, p = .001), lower number of periodontal pockets (≥4 mm) (β = -1.07, p = .007), and lower odds of having two or more periodontal pockets of ≥6 mm (OR = 0.80, 95% CI: 0.65 to 0.98) in fully adjusted models.
CMPF, a validated biomarker of fatty fish consumption, is associated with less periodontal inflammation and periodontitis. Residual confounding cannot be ruled out, and future studies are warranted.