films

Films
  • 文章类型: Historical Article
    本文通过心理学家PaulEkman在1960年代的早期工作,研究了将面部数据从其出现的背景中分离出来的详细过程。它探讨了埃克曼的数据实践是如何发展的,批评,并通过将它们置于他早期职业生涯的政治和知识环境中来妥协。这篇文章遵循埃克曼从兰利·波特神经精神研究所到新英格兰的旅程,强调他与心理学家CharlesE.Osgood和NIH研究人员D.CarletonGajdusek和E.RichardSorenson的简短但值得注意的合作。它认为,赋予人脸的不同含义导致每个小组如何发展他们的研究-无论是在互动中检查面部表情,他们在人际沟通中形成互惠行为,或者孤立地,面孔从个人无意识的内部浮出水面。
    This essay examines the detailed process of isolating facial data from the context of its emergence through the early work of psychologist Paul Ekman in the 1960s. It explores how Ekman\'s data practices have been developed, criticized, and compromised by situating them within the political and intellectual landscape of his early career. This essay follows Ekman\'s journey from the Langley Porter Neuropsychiatric Institute to New Guinea, highlighting his brief but notable collaborations with psychologist Charles E. Osgood and NIH researchers D. Carleton Gajdusek and E. Richard Sorenson. It argues that the different meanings assigned to the human face resulted in how each group developed their studies - examining facial expressions either in interaction, where they shape reciprocal actions in interpersonal communication, or in isolation, where faces surface from the individual\'s unconscious interior.
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  • 文章类型: Journal Article
    口腔粘膜病变(OML),这代表了世界范围内的重大公共卫生问题,包括口腔粘膜的任何病理变化,如溃疡,色素沉着,和肿胀。由于其潮湿和动态的复杂环境,设计口腔粘膜制剂提出了重大挑战。从贻贝中汲取灵感,本研究采用环保一锅法制备壳聚糖/聚多巴胺(CS/PDA)薄膜。我们证明了在酸性条件下CS诱导的多巴胺单体聚合,这可能归因于CS链的大量氢键位点。PDA显着增强CS膜的性能并表现出浓度依赖性。在浓度为1重量%的PDA,CS/PDA薄膜的搭接剪切强度和拉伸强度分别达到5.01±0.24kpa和4.20±0.78kpa,分别,表明粘膜粘附能力显著提高。与单一的CS膜相比,CS/PDA薄膜的溶胀率降低了约30%。流变结果还表明,循环大应变后储能模量恢复到93%,而单个CS膜仅恢复到73%。此外,这些薄膜表现出良好的生物相容性和增强大鼠口腔溃疡愈合,为OML的局部治疗提供了新的实用选择。
    Oral mucosal lesions (OML), which represent a major public health issue worldwide, include any pathological changes in the oral mucosa, such as ulcers, pigmentation, and swelling. Due to its humid and dynamic complex environment, designing oral mucosal preparations poses significant challenges. Drawing inspiration from mussels, this study employed an eco-friendly one-pot strategy for the preparation of chitosan/polydopamine (CS/PDA) films. We demonstrated that CS-induced polymerization of dopamine monomers under acidic conditions, which might be attributed to the large number of hydrogen bonding sites of CS chains. PDA markedly enhances properties of the CS film and exhibits concentration dependence. At the concentration of 1 wt% PDA, the lap-shear strength and tensile strength of CS/PDA films reached 5.01 ± 0.24 kpa and 4.20 ± 0.78 kpa, respectively, indicating that the mucosal adhesion ability was significantly improved. In comparison with the single CS film, the swelling rate of CS/PDA film decreased by about 30 %. Rheological results also showed that the storage modulus returned to 93 % after cyclic large strain, while the single CS film only recovered to 73 %. Moreover, these films demonstrated good biocompatibility and enhanced oral ulcer healing in rats, providing a new and practical option for the local treatment of OML.
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  • 文章类型: Journal Article
    食管疾病患病率的增加凸显了新的临床相关性,长效粘膜粘附口服剂型。EsoCap装置能够在食道中靶向局部应用膜。诸如EsoPeriDiss之类的生物相关测试系统对于早期配方开发至关重要。为此,开发和已经描述的用于模拟食道的释放模型正在进一步开发,因为它有潜力通过对生物相关释放介质的全面调温和研究来对应用部位进行生物相关映射。特别是粘稠的唾液制剂导致保留时间延长。此外,正在评估增加食管贴膜保留时间的可能配方策略,例如不同的薄膜厚度,聚合物等级和不同活性成分性质对保留时间的影响。对于高度可溶的活性成分,薄膜厚度代表延长保留时间的选项,而对于溶解性较低的物质,聚合物等级的选择可能是特别感兴趣的。
    The increasing prevalence of esophageal disease highlights the clinical relevance of novel, long-lasting mucoadhesive oral dosage forms. The EsoCap device enables targeted local application of films in the esophagus. Biorelevant test systems such as EsoPeriDiss are essential for early formulation development. To this end, the developed and already described release model for simulating the esophagus is being further developed for its potential for biorelevant mapping of the application site through complete tempering and investigation of biorelevant release media. Particularly viscous saliva formulations led to an extension of the retention time. In addition, possible formulation strategies for increasing the retention time of esophageal applied films are being evaluated, such as different film thicknesses, polymer grades and the influence of different active ingredient properties on the retention time. For highly soluble active ingredients, the film thickness represents an option for extending the retention time, while for less soluble substances, the choice of polymer grade may be of particular interest.
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  • 文章类型: Journal Article
    在这项研究中,我们提出了新颖的三层复合闪烁体,旨在同时检测不同的电离辐射成分。这些闪烁体基于LuAG和YAG石榴石的外延结构,掺杂Ce3+和Sc3+离子。这些复合闪烁体的样本,含有不同厚度的YAG:Ce和LuAG:Ce单晶薄膜和LuAG:Sc单晶衬底,使用液相外延方法从基于PbO-B2O3通量的熔体溶液中生长。所提出的复合材料的闪烁性能,YAG:Ce薄膜/LuAG:Sc薄膜/LuAG:Ce晶体和YAG:Ce薄膜/LuAG:Ce薄膜/LuAG:Sc晶体,在239Pu源的α粒子辐射激发下进行了研究,来自90Sr源的β粒子和来自137Cs源的γ射线。考虑到上述复合闪烁体的特性,特别注意使用闪烁衰减动力学同时分离包含上述粒子和量子的混合电离辐射的不同成分的能力。使用各种闪烁衰减强度水平下的品质因数(FOM)值(1/e,0.1、0.05、0.01)。
    In this study, we propose novel three-layer composite scintillators designed for the simultaneous detection of different ionizing radiation components. These scintillators are based on epitaxial structures of LuAG and YAG garnets, doped with Ce3+ and Sc3+ ions. Samples of these composite scintillators, containing YAG:Ce and LuAG:Ce single crystalline films with different thicknesses and LuAG:Sc single crystal substrates, were grown using the liquid phase epitaxy method from melt solutions based on PbO-B2O3 fluxes. The scintillation properties of the proposed composites, YAG:Ce film/LuAG:Sc film/LuAG:Ce crystal and YAG:Ce film/LuAG:Ce film/LuAG:Sc crystal, were investigated under excitation by radiation with α-particles from a 239Pu source, β-particles from 90Sr sources and γ-rays from a 137Cs source. Considering the properties of the mentioned composite scintillators, special attention was paid to the ability of simultaneous separation of the different components of mixed ionizing radiation containing the mentioned particles and quanta using scintillation decay kinetics. The differences in scintillation decay curves under α- and β-particle and γ-ray excitations were characterized using figure of merit (FOM) values at various scintillation decay intensity levels (1/e, 0.1, 0.05, 0.01).
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  • 文章类型: Journal Article
    流行病学和公共卫生问题主要依赖于对气体污染物的准确控制,需要高效的气体传感器设备检测有害气体。尽管在这个时代付出了许多努力,精确的,对气体的持续审查对于适当的气体选择性仍然难以捉摸,迅速响应和恢复时间,适当的可重复性,以及低成本。因此,纳米结构的建筑传感线索已经得到了广泛的关注,以通用的检测和传感程序。作为一种代表性的纳米结构,MXene系列已被广泛引入,通过提供大表面积来定制和增强传感器模式,可调表面化学,优越的导电性,化学稳定性,与柔性基板的兼容性,和多功能性的潜力。此外,它们可以以各种薄膜和分层设计的形式合成,纤维膜,和凝胶状结构,创造协同效应,可以提供卓越的气体传感性能。在这里,MXene纳米片作为气敏材料的合成和好处,与MXene基气体传感器在薄膜形成方面的过去到现在的进展相一致,纤维状,和凝胶状结构,全面审查。作为一个深入的参考,本概述可以阐明进一步推进基于MXene结构开发的气体传感器架构。
    Epidemiology and public health concerns have primarily relied on the accurate control of gas pollutants, requiring highly efficient gas sensor devices for detecting hazardous gases. Despite the dedication of many efforts in this era, the precise, continuous scrutiny of gases remains elusive for appropriate gas selectivity, prompt response and recovery time, proper repeatability, as well as low cost. Accordingly, nanostructured architectural sensing cues have received enormous attention toward versatile detection and sensing procedures. As a representational nanostructure, the MXene family has been widely introduced to tailor and augment sensor patterns by providing large surface area, tunable surface chemistry, superior electrical conductivity, chemical stability, compatibility with flexible substrates, and potential for multifunctionality. Additionally, they could be synthesized in various formations of film and layered designs, fibrous membranes, and gel-like structures, creating synergetic effects that can provide superior gas-sensing performance. Herein, the synthesis and benefits of MXene nanosheets as gas-sensitive materials, in tandem with the past-to-present progress of MXene-based gas sensors in the formation of films, fibrous, and gel-like configurations, are comprehensively reviewed. As an in-depth reference, the present overview could shed light on further advancing gas sensor architectures developed based on MXene structures.
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  • 文章类型: Journal Article
    基于Ulvaspp的水热分馏的简单级联过程。生物质被提出。考虑到总提取率(50%),ulvan恢复(23%),和ulvan组成,结构,机械和细胞毒性特性,选择的最佳最终加热温度为160°C。乙醇沉淀提供了最高的ulvan回收率,但氯化胆碱沉淀的ulvans显示出更强的机械性能,乙醇和氯化胆碱的G'模量为1.5·104Pa和3·104Pa,分别。两种产品在L929小鼠成纤维细胞和冷却阶段后都是安全的,形成的薄膜不需要任何添加剂。从无乌尔文的液体馏分中,一种产品占43%(重量,d.b.)分离了酚类和中等的抗自由基特性以及含有营养素和矿物质的副产物。相应的残留固体的甲烷势受到水热加热温度的影响,与未处理的海藻生物质(60mL/gVS)相比,是两倍。该方案也可以应用于湿藻类生物质,在一个无化学物质的替代品中,提供随时可用的ulvan生物聚合物,生物活性物质,营养素,盐和沼气,符合生物炼制方法。
    A simple cascade process based on the hydrothermal fractionation of Ulva spp. biomass was proposed. Considering the overall extraction yields (50 %), ulvan recovery (23 %), and ulvan composition, structural, mechanical and cytotoxic properties, the selected optimal final heating temperature was 160 °C. Ethanol precipitation provided the highest ulvan recovery yields but choline chloride precipitated ulvans showed stronger mechanical properties, G´ moduli 1.5·104 Pa and 3·104 Pa for ethanol and for choline chloride, respectively. Both products were safe on NCTC 929 mouse fibroblasts and after a cooling stage, formed films without requiring any additives. From the ulvan-free liquid fraction, one product with 43 % (wt, d.b.) phenolics and moderate antiradical properties and a byproduct containing nutrients and minerals were separated. The methane potential of the corresponding residual solids was influenced by the hydrothermal heating temperature and was doubled compared to than for the untreated seaweed biomass (60 mL/g VS). This scheme could be also applied to the wet algal biomass, in a chemical free alternative to provide ready to use ulvan biopolymers, bioactives, nutrients, salts and biogas, conforming a biorefinery approach.
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  • 文章类型: Journal Article
    目的:本研究旨在确定与职业相关的电影对护生职业自豪感的影响。
    方法:本研究采用随机对照实验设计进行。
    方法:该研究的样本包括102名在护理学院第一年注册的学生,2022-2023学年位于蒂尔基耶的宗古尔达克·布伦特·埃切维特大学。这些学生被随机分配到实验组(n=57)和对照组(n=45)。实验小组在YouTube上观看了两部纪录片和一部电影,并休息了一周。自我管理的在线问卷通过WhatsApp小组分发,用于前测和后测。数据是通过GoogleForms平台上准备的调查表中包含的“社会人口统计学数据表格”和“护理专业自豪感量表(NPPS)”收集的。使用Spearman的rho分析数据,Mann-WhitneyU测试,和Wilcoxon符号等级测试.
    结果:参与者的平均年龄为18.80±0.99岁,80%的参与者是女性,79.4%的人一生中居住时间最长的地方是城市,85.3%的人在上大学之前就有关于护理专业的信息(36.8%来自互联网,34.6%来自周围的人)。干预后实验组NPPS评分明显高于对照组(p=0.017)。在实验组中,职业感觉(p=0.012)和继续职业的愿望(p=0.002)的维度也显着增加。
    患者和公众没有参与这项研究。
    OBJECTIVE: This study aimed to determine the effects of profession-related films on the professional pride of nursing students.
    METHODS: The study was conducted with a randomised controlled experimental design.
    METHODS: The sample of the study consisted of 102 students enrolled in the first year of the School of Nursing, Zonguldak Bulent Ecevit University in Türkiye in the 2022-2023 academic year. These students were randomly assigned to the experimental (n = 57) and control (n = 45) groups. The experimental group watched two documentaries and a film on YouTube with a one-week break. Self-administered online questionnaires were distributed via WhatsApp groups for pretests and posttests. Data were collected with a \"Sociodemographic Data Form\" and the \"Nursing Professional Pride Scale (NPPS)\" included in the questionnaire forms prepared on the Google Forms platform. Data were analysed using Spearman\'s rho, the Mann-Whitney U Test, and the Wilcoxon Signed-Rank Test.
    RESULTS: The mean age of the participants was 18.80 ± 0.99 years, 80% of the participants were female, the place where 79.4% had lived for the longest duration in their lives was the city, 85.3% had information about the profession of nursing before they started university (36.8% from the internet, 34.6% from people around them). The experimental group had significantly higher NPPS scores than the control group after the intervention (p = 0.017). There was also a significant increase in the dimensions of professional feeling (p = 0.012) and desire to continue the profession in the experimental group (p = 0.002).
    UNASSIGNED: Patients and public were not involved in this research.
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  • 文章类型: Journal Article
    牙周炎是一种影响支持牙周组织的炎症疾病。它是由牙龈对牙菌斑的免疫反应引发的,导致牙周附着结构的破坏。牙周炎是世界上最常见的牙科疾病之一,也是成人牙齿脱落的主要因素。缩放和根部平整对于治疗持续性牙周炎患者仍然至关重要。然而,完全依赖牙周手术等机械干预,提取,和牙根规划不足以阻止牙周炎的进展。针对细菌耐药性的问题,一些研究人员致力于寻找抗生素的替代疗法。此外,一些学者致力于寻找新材料,为牙周组织再生提供强大的微环境,促进成骨修复。纳米颗粒具有独特的治疗品质,包括特殊的抗菌,抗炎,和抗氧化性能,免疫调节能力,和促进骨再生能力,这使得它们可以用于牙周炎的治疗。然而,有许多问题限制了纳米粒子的临床翻译,例如细胞中的毒性积累,体内外相关性差,和差的动物到人的可传播性。在本文中,我们从三个主要类别的角度综述了纳米粒子在牙周炎治疗中的研究现状:无机纳米粒子,有机纳米粒子,和纳米复合材料(包括纳米纤维,水凝胶,和膜)。这篇综述的目的是提供有关基于纳米粒子的牙周炎疗法的全面和最新的更新。结语部门总结了用于牙周炎医治的纳米粒设计和临床翻译中的机会和挑衅。
    Periodontitis is a disease of inflammation that affects the tissues supporting the periodontium. It is triggered by an immunological reaction of the gums to plaque, which leads to the destruction of periodontal attachment structures. Periodontitis is one of the most commonly recognized dental disorders in the world and a major factor in the loss of adult teeth. Scaling and root planing remain crucial for managing patients with persistent periodontitis. Nevertheless, exclusive reliance on mechanical interventions like periodontal surgery, extractions, and root planning is insufficient to halt the progression of periodontitis. In response to the problem of bacterial resistance, some researchers are committed to finding alternative therapies to antibiotics. In addition, some scholars focus on finding new materials to provide a powerful microenvironment for periodontal tissue regeneration and promote osteogenic repair. Nanoparticles possess distinct therapeutic qualities, including exceptional antibacterial, anti-inflammatory, and antioxidant properties, immunomodulatory capacities, and the promotion of bone regeneration ability, which made them can be used for the treatment of periodontitis. However, there are many problems that limit the clinical translation of nanoparticles, such as toxic accumulation in cells, poor correlation between in vitro and in vivo, and poor animal-to-human transmissibility. In this paper, we review the present researches on nanoparticles in periodontitis treatment from the perspective of three main categories: inorganic nanoparticles, organic nanoparticles, and nanocomposites (including nanofibers, hydrogels, and membranes). The aim of this review is to provide a comprehensive and recent update on nanoparticles-based therapies for periodontitis. The conclusion section summarizes the opportunities and challenges in the design and clinical translation of nanoparticles for the treatment of periodontitis.
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  • 文章类型: Journal Article
    本文探讨了柑橘残留物作为包装膜生产的不同果胶材料的来源:水溶性橙渣提取物(WSE)(〜5%果胶),在柠檬酸(SP)中提取的半纯果胶(〜50%果胶),和商业纯柑橘果胶(CP)。首先,这些材料在化学组成方面进行了表征。然后,使用它们纯的或通过溶剂流延与壳聚糖或甘油混合来生产膜。最后,抗氧化活性,功能特性(例如,机械和气体阻隔性能),并评估膜的视觉外观。WSE膜表现出最高的抗氧化活性,但机械强度最低,断裂伸长率(EB)最高(54%);掺入壳聚糖增加了膜的强度(杨氏模量高35.5倍)。SP薄膜表现出中等的机械性能,通过添加壳聚糖增强(杨氏模量高4.7倍);它们表现出优异的干O2屏障。CP薄膜表现出与SP薄膜相似的O2阻隔,并具有最高的杨氏模量(〜29MPa)。但是它们的脆性需要甘油来改善柔韧性,和壳聚糖的添加损害了它们的表面规则性。总的来说,果胶材料的类型决定了薄膜的性能,较少精制的果胶提供与纯商业果胶一样多的好处。
    This article explores the use of citrus residues as a source of different pectic materials for packaging film production: a water-soluble orange residue extract (WSE) (~5% pectin), semi-pure pectins extracted in citric acid (SP) (~50% pectin), and commercial pure citrus pectins (CP). First, these materials were characterized in terms of chemical composition. Then, films were produced using them pure or mixed with chitosan or glycerol through solvent-casting. Finally, antioxidant activity, functional properties (e.g., mechanical and gas barrier properties), and visual appearance of the films were assessed. WSE films showed the highest antioxidant activity but the lowest mechanical strength with the highest elongation at break (EB) (54%); incorporating chitosan increased the films\' strength (Young\'s modulus 35.5 times higher). SP films showed intermediate mechanical properties, reinforced by chitosan addition (Young\'s modulus 4.7 times higher); they showed an outstanding dry O2 barrier. CP films showed a similar O2 barrier to SP films and had the highest Young\'s modulus (~29 MPa), but their brittleness required glycerol for improved pliability, and chitosan addition compromised their surface regularity. Overall, the type of pectic material determined the film\'s properties, with less-refined pectins offering just as many benefits as pure commercial ones.
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  • 文章类型: Journal Article
    通过流延法制备了一系列基于TEMPO-氧化壳聚糖纳米颗粒的新型薄膜。傅里叶变换红外光谱(FTIR)用于确定TEMPO氧化壳聚糖的化学结构。通过原子力显微镜(AFM)分析了TEMPO氧化的壳聚糖纳米颗粒的表面形态。物理化学(面积密度,厚度,碘吸附,粗糙度),功能性(吸湿,液体吸收能力,与液体接触后的重量损失,和水蒸气透过率),抗菌,并研究了基于TEMPO氧化壳聚糖纳米颗粒的薄膜的抗氧化性能。薄膜的物理化学性质变化很大:面积密度在77.83±0.06至184.46±0.05mg/cm2之间,厚度在80.5±1.6和200.5±1.6μm之间变化,碘吸附范围从333.7±2.1到166.4±2.2mgI2/g,粗糙度范围为4.1±0.2至5.6±0.3nm。同样,功能特性也有显著变化:吸湿性范围从4.76±0.03到9.62±0.11%,24h后液体吸收能力在129.04±0.24和159.33±0.73%之间,24小时后,与液体接触后的体重减轻在31.06±0.35和45.88±0.58%之间,水蒸气透过率在1220.10±2.91至1407.77±5.22g/m2天之间。尽管物理化学和功能特性有很大差异,所有薄膜显示金黄色葡萄球菌和大肠杆菌的最大细菌减少,尽管它们表现出低抗氧化活性。结果表明,该薄膜可以有效地用作抗菌伤口敷料。
    A series of novel films based on TEMPO-oxidized chitosan nanoparticles were prepared by casting method. Fourier transform infrared spectroscopy (FTIR) was employed to ascertain the chemical structure of TEMPO-oxidized chitosan. The surface morphology of the TEMPO-oxidized chitosan nanoparticles was analyzed by atomic force microscopy (AFM). The physicochemical (area density, thickness, iodine sorption, roughness), functional (moisture sorption, liquid absorption capacity, weight loss upon contact with the liquid, and water vapor transmission rate), antibacterial, and antioxidant properties of films based on TEMPO-oxidized chitosan nanoparticles were also investigated. The physicochemical properties of the films varied widely: area density ranged from 77.83 ± 0.06 to184.46 ± 0.05 mg/cm2, thickness varied between 80.5 ± 1.6 and 200.5 ± 1.6 μm, iodine sorption spanned from 333.7 ± 2.1 to166.4 ± 2.2 mg I2/g, and roughness ranged from 4.1 ± 0.2 to 5.6 ± 0.3 nm. Similarly, the functional properties also varied significantly: moisture sorption ranged from 4.76 ± 0.03 to 9.62 ± 0.11 %, liquid absorption capacity was between 129.04 ± 0.24 and 159.33 ± 0.73 % after 24 h, weight loss upon contact with the liquid varied between 31.06 ± 0.35 and 45.88 ± 0.58 % after 24 h and water vapor transmission rate ranged from 1220.10 ± 2.91to1407.77 ± 5.22 g/m2 day. Despite the wide variations in physicochemical and functional properties, all films showed maximum bacterial reduction of Staphylococcus aureus and Escherichia coli, although they exhibited low antioxidant activity. The results suggest that the films could be effectively utilized as antibacterial wound dressings.
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