背景:儿科姑息治疗(PPC)患者营养不良的风险增加。营养不足也会导致微量营养素缺乏。这些因素会导致体重减轻,发育迟缓,和生活质量差。尽管这些问题普遍存在,PPC患者的微量营养素状态研究有限。这项研究的目的是确定维生素B12和D,铁,铁蛋白,叶酸,钙,磷,PPC患者的镁水平有助于更好地了解他们的微量营养素需求以及饮食和治疗方法的适当管理。
方法:这是一项单中心观察性横断面回顾性研究。这项研究评估了维生素B12,25-羟基维生素D,铁,铁蛋白,叶酸,钙,磷,PPC患者的镁。根据慢性复杂状况(CCC)v2对患者进行分类,然后进行比较。
结果:共收集了364例患者中822例住院患者的3,144个微量营养素数据点。在96.9%的患者中发现至少一种微量营养素缺乏。最普遍的缺乏是铁,钙,和磷酸盐。此外,在三分之一的患者中观察到25-羟基维生素D缺乏。钙,镁,磷,叶酸,25-羟维生素D与年龄呈负相关。
结论:这项研究的结果表明,微量营养素缺乏在PPC患者中非常普遍。这些发现有可能有助于改善患者的营养和治疗管理。
BACKGROUND: Pediatric palliative care (PPC) patients are at an elevated risk of malnutrition. Nutritional inadequacy can also cause micronutrient deficiencies. These factors can lead to weight loss, stunted growth, and poor quality of life. Despite the prevalence of these issues, limited research exists in the micronutrient status of PPC patients. The purpose of this study was to determine the vitamin B12 and D, iron, ferritin, folate, calcium, phosphorus, and magnesium levels of PPC patients to contribute to a better understanding of their micronutrient needs as well as the appropriate management of diet and treatment approaches.
METHODS: This was a single-center observational cross-sectional retrospective study. This study evaluated the levels of vitamin B12, 25-hydroxyvitamin D, iron, ferritin, folate, calcium, phosphorus, and magnesium in PPC patients. The patients were classified according to the Chronic Complex Conditions (CCC) v2 and then compared.
RESULTS: A total of 3,144 micronutrient data points were collected from 822 hospitalizations of 364 patients. At least one micronutrient deficiency was identified in 96.9% of the patients. The most prevalent deficiencies were observed for iron, calcium, and phosphate. In addition, 25-hydroxyvitamin D deficiency was observed in one-third of patients. Calcium, magnesium, phosphorus, folate, and 25-hydroxyvitamin D were negatively correlated with age.
CONCLUSIONS: The results of this study indicate that micronutrient deficiencies are highly prevalent in PPC patients. These findings have the potential to contribute to improvements in the nutritional and therapeutic management of patients.