新生儿低血糖(NH)被广泛地定义为引起低血糖诱导的脑功能受损的低血浆葡萄糖浓度。迄今为止,尚未公布新生儿血浆葡萄糖水平的普遍接受的阈值(参考范围),因为数据一致表明,在不同的血浆葡萄糖浓度下,对低血糖的神经系统反应不同。有NH风险的婴儿包括糖尿病母亲的婴儿,胎龄小或大,和早产儿。常见的表现包括抖动,喂养不良,烦躁,和脑病。与NH相关的神经发育障碍包括认知和运动延迟,脑瘫,视力和听力障碍,和糟糕的学校表现。本文及时讨论了NH的科学状况,并为新生儿提供者提供了有关早期识别和疾病预防的建议。
Neonatal hypoglycemia (NH) is broadly defined as a low plasma glucose concentration that elicits hypoglycemia-induced impaired brain function. To date, no universally accepted threshold (reference range) for plasma glucose levels in newborns has been published, as data consistently indicate that neurologic responses to hypoglycemia differ at various plasma glucose concentrations. Infants at risk for NH include infants of diabetic mothers, small or large for gestational age, and premature infants. Common manifestations include jitteriness, poor feeding, irritability, and encephalopathy. Neurodevelopmental morbidities associated with NH include cognitive and motor delays, cerebral palsy, vision and hearing impairment, and poor school performance. This article offers a timely discussion of the state of the science of NH and recommendations for neonatal providers focused on early identification and disease prevention.