未经评估:与年龄相关的肌肉质量和功能下降是在临床实践和研究中引起关注的关键问题。然而,关于肌肉健康进展的时间过程知之甚少,以及它在这个转变过程中的决定因素应该被估计出来。
UNASSIGNED:我们招募了年龄≥65岁的社区居住成年人,在他们的常规健康检查中。从2015年到2021年,每年对参与者的身体成分和肌肉功能进行测量。节前减少症的特征仅在于肌肉质量的损失;功能障碍被定义为肌肉功能低下,而肌肉质量没有变化;肌肉减少症被指示为肌肉质量和肌肉功能的下降。我们观察了衰老过程中肌肉健康发展的自然过程。研究了老年人肌肉健康下降与不同决定因素之间的关系。
未经评估:在568名参与者中,有18.49%,3.52%,和1.06%的健康个体过渡到肌张力障碍,先兆减少症,和肌少症,分别。年龄之间显著正相关,存在脂肪肌肉比(FMR)和功能障碍转换[风险比(HR)=1.08和HR=1.73,均p<0.05].血清白蛋白水平与糖尿病转换风险呈负相关(HR=0.30,p=0.004)。与没有这三个危险因素的参与者相比,具有这三个危险因素的参与者具有最高的失调症转换HR(HR=8.67,p=0.001)。在危险因素数量和功能障碍转变的风险之间存在剂量反应效应(趋势p<0.001)。在多个协变量调整后,这种正相关和剂量反应关系仍然存在(HR=7.74,p=0.002,趋势p<0.001)。具有两个或两个以上危险因素的参与者比具有低危险因素的参与者具有更高的功能障碍过渡风险(p=0.0027)。多重协变量调整后HR为1.96(p=0.029)。
未经评估:健康社区居住的老年人倾向于在肌肉健康恶化期间转变为肌强弱症。年龄较大的人,更高的FMR,较低的白蛋白水平有较高的营养不良过渡风险;并且在该人群中也存在正的剂量-反应效应.
UNASSIGNED: Age-related muscle mass and function decline are critical issues that have gained attention in clinical practice and research. Nevertheless, little is known regarding the time course of muscle health progression, and its determinants during this transition should be estimated.
UNASSIGNED: We enrolled community-dwelling adults aged ≥65 years during their regular health checkup. The participants\' body composition and muscle function were measured annually from 2015 to 2021. Presarcopenia was characterized by the loss of muscle mass only; dynapenia was defined as low muscle function without changes in muscle mass; and sarcopenia was indicated as a decline in both muscle mass and muscle function. We observed the natural course of muscle health progression during aging. The relationship between muscle health decline and different determinants among old adults was examined.
UNASSIGNED: Among 568 participants, there was 18.49%, 3.52%, and 1.06% of healthy individuals transited to dynapenia, presarcopenia, and sarcopenia, respectively. Significant positive correlations between age, fat-to-muscle ratio (FMR) and the dynapenia transition were existed [hazard ratio (HR) = 1.08 and HR = 1.73, all p < 0.05]. Serum albumin level had negative correlation with the dynapenia transition risk (HR = 0.30, p = 0.004). Participants with these three risk factors had the highest HR of dynapenia transition compared to those without (HR = 8.67, p = 0.001). A dose-response effect existed between risk factors numbers and the risk of dynapenia transition (p for trend < 0.001). This positive association and dose-response relationship remains after multiple covariates adjustment (HR = 7.74, p = 0.002, p for trend < 0.001). Participants with two or more than two risk factors had a higher risk of dynapenia transition than those with low risk factors (p = 0.0027), and the HR was 1.96 after multiple covariate adjustment (p = 0.029).
UNASSIGNED: Healthy community-dwelling old adults tended to transit to dynapenia during muscle health deterioration. Individuals with older age, higher FMR, lower albumin level had a higher risk of dynapenia transition; and a positive dose-response effect existed among this population as well.