聚(l-乳酸)(PLLA)常用于生物可吸收医疗植入物,但它遭受缓慢的降解速率和快速下降的机械性能的骨科应用。为了解决这个缺点,最近的研究探索了Mg作为PLLA填料的用途,导致与纯PLLA相比具有改善的降解速率和细胞相容性的复合材料。在这项研究中,提出了FeMg粉末颗粒作为PLLA的填料,以研究PLLA/FeMg复合材料用于生物可吸收植入物的潜力。PLLA的圆柱体试样,PLLA/Fe,PLLA/Mg和PLLA/FeMg是使用溶剂浇铸然后热成型制备的。微观结构,热行为,在模拟体液中的体外降解行为,研究了这些复合材料的力学性能和细胞相容性。结果表明,FeMg颗粒的存在可以防止复合材料力学性能的恶化,至少14天。一旦复合材料达到一定量的降解,降解速度比PLLA快。直接的细胞毒性实验表明,前成骨细胞MC3T3-E1细胞成功地粘附并在PLLA/FeMg表面上增殖。在Fe晶格中包含低百分比的Mg不仅加速了Fe的降解速率,而且还改善了其细胞相容性。提高降解率,机械性能,这种复合材料的骨传导特性使其成为临时骨科生物医学设备的有希望的选择。
Poly(l-lactic) acid (PLLA) is commonly used in bioabsorbable medical implants, but it suffers from slow degradation rate and rapid decline in mechanical properties for orthopedic applications. To address this drawback, recent research has explored the use of Mg as a filler for PLLA, resulting in composites with improved degradation rate and cytocompatibility compared to neat PLLA. In this study,
FeMg powder particles were proposed as fillers for PLLA to investigate the potential of PLLA/
FeMg composites for bioabsorbable implants. Cylinder specimens of PLLA, PLLA/Fe, PLLA/Mg and PLLA/
FeMg were prepared using solvent casting followed by thermo-molding. The microstructure, thermal behavior, in vitro degradation behavior in simulated body fluid, mechanical properties and cytocompatibility of these composites were examined. The results indicate that the presence of
FeMg particles prevents the deterioration of the composite mechanical properties, at least up to 14 days. Once a certain amount of degradation of the composite is reached, the degradation is faster than that of PLLA. Direct cytotoxicity assays revealed that pre-osteoblast MC3T3-E1 cells successfully adhered to and proliferated on the PLLA/
FeMg surface. The inclusion of a low percentage of Mg into the Fe lattice not only accelerated the degradation rate of Fe but also improved its cytocompatibility. The enhanced degradation rate, mechanical properties, and osteoconductive properties of this composite make it a promising option for temporary orthopedic biomedical devices.