在极早产新生儿康复治疗中使用脐带来源的自体间充质基质细胞治疗的2例临床病例(妊娠27-28周,体重900和870克,分别)描述了缺氧缺血性脑病。女孩是剖腹产的;1分钟Apgar评分为6分。包括人工通气在内的复苏后,在缺氧缺血性脑病发展的背景下实现了病情的稳定。康复治疗包括施用出生时收获的脐带来源的间充质基质细胞。在3、6、12个月(第一患者)和3、6、9、15个月(第二患者)的年龄以1.6-7百万/kg体重的剂量注射细胞。使用Hellbrügge量表对心理神经发育迟缓进行评分。细胞治疗无明显不良反应,改善患儿精神运动发育。
Two clinical cases of the use of cell therapy with umbilical cord-derived autologous mesenchymal stromal cells in the rehabilitation therapy of extremely premature newborns (27-28 weeks gestation, body weights 900 and 870 g, respectively) with hypoxic-ischemic encephalopathy are described. The girls were born by caesarean section; the 1-min Apgar score was 6 points. After resuscitation including artificial ventilation, stabilization of the condition was achieved against the background of the development of hypoxic-ischemic encephalopathy. Rehabilitation therapy included administration of umbilical cord-derived mesenchymal stromal cells harvested at birth. The cells were injected in a dose of 1.6-7 million/kg body weight at the age of 3, 6, 12 months (the first patient) and 3, 6, 9, 15 months (the second patient). Psychoneurological developmental delay was scored using the Hellbrügge scale. Cell therapy induced no significant adverse reactions and improved the psychomotor development of children.