■前列腺癌侵入胶囊是选择适当治疗方法的关键因素。术前准确预测前列腺外扩张(EPE)有助于实现治疗方案的精确选择。
■本研究的目的是验证肿瘤大小的诊断效能,囊接触长度(LCC),表观扩散系数(ADC),和酰胺质子转移(APT)值在预测EPE中的作用。此外,该研究旨在探讨APT对预测EPE的潜在附加价值。
■本研究包括47名肿瘤器官受限患者(年龄,64.16±9.18)和50例EPE患者(年龄,61.51±8.82)。肿瘤大小的差异,LCC,比较各组间ADC值及APT值。二元逻辑回归用于筛选EPE预测因子。进行了受试者操作员特征曲线分析,以评估用于预测EPE的变量的诊断性能。还分析了组合模型(模型I:ADC+LCC+肿瘤大小;模型II:APT+LCC+肿瘤大小;和模型III:APT+ADC+LCC+肿瘤大小)的诊断功效。
■APT,ADC,肿瘤大小和LCC是EPE的独立预测因子。APT曲线下面积(AUC),ADC,肿瘤大小和LCC分别为0.752、0.665、0.700和0.756。模型I的AUC,模型II,模型III分别为0.803、0.845和0.869。APT的截止值,ADC,肿瘤大小和LCC为3.65%,0.97×10-3mm2/s,17.30mm和10.78mm,分别。APT的敏感性/特异性,ADC,肿瘤大小和LCC分别为76%/89.4%,80%/59.6%,54%/78.9%,72%/66%,分别。模型I的敏感性/特异性,模型II和模型III分别为74%/72.3%,82%/72.5%和84%/80.9%,分别。
■酰胺质子转移成像对预测EPE具有附加价值。APT的组合模型平衡了敏感性和特异性。
UNASSIGNED: Prostate cancer invades the capsule is a key factor in selecting appropriate treatment methods. Accurate preoperative prediction of extraprostatic extension (EPE) can help achieve precise selection of treatment plans.
UNASSIGNED: The aim of this study is to verify the diagnostic efficacy of tumor size, length of capsular contact (LCC), apparent diffusion coefficient (ADC), and Amide proton transfer (APT) value in predicting EPE. Additionally, the study aims to investigate the potential additional value of APT for predicting EPE.
UNASSIGNED: This study include 47 tumor organ confined patients (age, 64.16 ± 9.18) and 50 EPE patients (age, 61.51 ± 8.82). The difference of tumor size, LCC, ADC and APT value between groups were compared. Binary logistic regression was used to screen the EPE predictors. The receiver operator characteristic curve analysis was performed to assess the diagnostic performance of variables for predicting EPE. The diagnostic efficacy of combined models (model I: ADC+LCC+tumor size; model II: APT+LCC+tumor size; and model III: APT +ADC+LCC+tumor size) were also analyzed.
UNASSIGNED: APT, ADC, tumor size and the LCC were independent predictors of EPE. The area under the curve (AUC) of APT, ADC, tumor size and the LCC were 0.752, 0.665, 0.700 and 0.756, respectively. The AUC of model I, model II, and model III were 0.803, 0.845 and 0.869, respectively. The cutoff value of APT, ADC, tumor size and the LCC were 3.65%, 0.97×10-3mm2/s, 17.30mm and 10.78mm, respectively. The sensitivity/specificity of APT, ADC, tumor size and the LCC were 76%/89.4.0%, 80%/59.6%, 54%/78.9%, 72%/66%, respectively. The sensitivity/specificity of model I, Model II and Model III were 74%/72.3%, 82%/72.5% and 84%/80.9%, respectively.
UNASSIGNED: Amide proton transfer imaging has added value for predicting EPE. The combination model of APT balanced the sensitivity and specificity.