■Exergaming有可能通过游戏增加对锻炼的坚持,个性化培训,和(在线)远程监控。RealityDigitalTherapeutics(RealityDTx®)是用于增强现实(AR)眼镜的数字治疗软件平台,可实现专门为帕金森氏症(pwPD)患者设计的基于家庭的步态和平衡运动干预。
■主要目标是评估RealityDTx®AR运动干预改善步态的可行性和潜在功效,balance,和步行适应性跌倒风险指标。次要目标是评估AR眼镜的潜在优势[MagicLeap2(ML2)与HoloLens2(HL2)]。
■这项等待名单控制的临床可行性研究包括三次实验室访视(基线、干预前和干预后),家访,以及为期6周的AR运动干预。远程规定了五个互补的步态和平衡运动游戏(默认为五个会话/周,30分钟/会话),监控,和量身定制的。在安全性方面进行了可行性评估,坚持,和用户体验。在实验室访问期间,使用标准临床步态和平衡测试和高级步行适应性跌倒风险评估来评估步态和平衡能力.
■总共,24pwPD参加。据报道没有跌倒和四个附近跌倒。会话依从性为104%。RealityDTx®的用户体验问卷得分从高于平均水平到优秀不等,在明晰性和可靠性方面,HL2得分优于ML2。在计时和围棋测试中观察到了干预效果(尽管很小),五次坐以待毙,步行速度。步行适应性跌倒风险指标均改善了干预后。
■RealityDTx®是安全的,可附着的,可用,被广泛接受,以及pwPD的潜在有效干预。这些有希望的结果保证了未来的随机对照试验(成本)有效性的家庭为基础的AR运动干预措施,以改善步态,balance,跌倒风险。
■ClinicalTrials.gov,标识符NCT05605249。
UNASSIGNED: Exergaming has the potential to increase adherence to exercise through play, individually tailored training, and (online) remote monitoring. Reality Digital Therapeutics (Reality DTx®) is a digital therapeutic software platform for augmented reality (AR) glasses that enables a home-based gait-and-balance
exergaming intervention specifically designed for people with Parkinson\'s disease (pwPD).
UNASSIGNED: The primary objective was to evaluate the feasibility and potential efficacy of Reality DTx® AR
exergaming intervention for improving gait, balance, and walking-adaptability fall-risk indicators. The secondary objective was to evaluate the potential superiority of AR glasses [Magic Leap 2 (ML2) vs. HoloLens 2 (HL2)].
UNASSIGNED: This waitlist-controlled clinical feasibility study comprised three laboratory visits (baseline; pre-intervention; and post-intervention), a home visit, and a 6-week AR
exergaming intervention. Five complementary gait-and-balance exergames were remotely prescribed (default five sessions/week of 30 active minutes/session), monitored, and tailored. Feasibility was assessed in terms of safety, adherence, and user experience. During laboratory visits, gait-and-balance capacity was assessed using standard clinical gait-and-balance tests and advanced walking-adaptability fall-risk assessments.
UNASSIGNED: In total, 24 pwPD participated. No falls and four near falls were reported. Session adherence was 104%. The User Experience Questionnaire scores for Reality DTx® ranged from above average to excellent, with superior scores for HL2 over ML2 for Perspicuity and Dependability. Intervention effects were observed for the Timed Up and Go test (albeit small), the Five Times Sit to Stand test, and walking speed. Walking-adaptability fall-risk indicators all improved post-intervention.
UNASSIGNED: Reality DTx® is a safe, adherable, usable, well-accepted, and potentially effective intervention in pwPD. These promising results warrant future randomized controlled trials on the (cost-)effectiveness of home-based AR
exergaming interventions for improving gait, balance, and fall risk.
UNASSIGNED: ClinicalTrials.gov, identifier NCT05605249.