The growing and ubiquitous digitalization trends embodied in eHealth initiatives have led to the widespread adoption of digital solutions in the healthcare sector. These initiatives have been heralded as a potent transformative force aiming to improve healthcare delivery, enhance patient outcomes and increase the efficiency of healthcare systems. However, despite the significant potential and possibilities offered by eHealth initiatives, the article highlights the importance of critically examining their implications and cautions against the misconception that technology alone can solve complex public health concerns and healthcare challenges. It emphasizes the need to critically consider the sociocultural context, education and training, organizational and institutional aspects, regulatory frameworks, user involvement and other important factors when implementing eHealth initiatives. Disregarding these crucial elements can render eHealth initiatives inefficient or even counterproductive. In view of that, the article identifies failures and fallacies that can hinder the success of eHealth initiatives and highlights areas where they often fall short of meeting rising and unjustified expectations. To address these challenges, the article recommends a more realistic and evidence-based approach to planning and implementing eHealth initiatives. It calls for consistent research agendas, appropriate evaluation methodologies and strategic orientations within eHealth initiatives. By adopting this approach, eHealth initiatives can contribute to the achievement of societal goals and the realization of the key health priorities and development imperatives of healthcare systems on a global scale.

UNASSIGNED: Political appeal and social pressure, combined with law ambiguity and lack of resources, to avoid the hard decisions, often have brought to a simplified model of inclusive education and to an apparently simplistic solution: opting for the location of education for children with special educational needs and dis¬abilities instead of tackling the routes of the problem.
UNASSIGNED: Within this context, the current research aims to explore the fundamental characteristics of inclusive education, highlighting the bio-psycho-social evidence-based approach in education.
UNASSIGNED: The method applied in the present work is explorative-reflective research on what can be regarded as inclusive education, education for all, and social capital psychoeducation as benchmarks for an integrative society.
UNASSIGNED: This research concludes that the inclusive education is not an emergency-adaptive pedagogy but has to be conceived as a medical psycho-pedagogy of raising awareness in healthy personalities and social inclusion, not shunning differences but observing them and seeking to offer to everyone the best opportunities for personal and community growth. Compared to the traditional concept of inclusion, the theoretical perspective of evidence-based approach has a much broader scope and it embraces the fact that inclusive education carries intrinsically also a risk of exclusion that must be actively prevented, and at the same time affirms the importance of involving all actors in creating a truly welcoming community, which must become sensitive to the full range of differences present in children\'s life.

Objectives: To provide a step-by-step, easy-to-understand, practical guide for systematic review and meta-analysis of observational studies. Methods: A multidisciplinary team of researchers with extensive experience in observational studies and systematic review and meta-analysis was established. Previous guidelines in evidence synthesis were considered. Results: There is inherent variability in observational study design, population, and analysis, making evidence synthesis challenging. We provided a framework and discussed basic meta-analysis concepts to assist reviewers in making informed decisions. We also explained several statistical tools for dealing with heterogeneity, probing for bias, and interpreting findings. Finally, we briefly discussed issues and caveats for translating results into clinical and public health recommendations. Our guideline complements \"A 24-step guide on how to design, conduct, and successfully publish a systematic review and meta-analysis in medical research\" and addresses peculiarities for observational studies previously unexplored. Conclusion: We provided 7 steps to synthesize evidence from observational studies. We encourage medical and public health practitioners who answer important questions to systematically integrate evidence from observational studies and contribute evidence-based decision-making in health sciences.

Unvalidated theories have been proposed for the etiopathogenesis of masticatory myofascial temporomandibular disorders (mTMD). Modalities such as cone-beam computed tomography/computed tomography and MRI contributes little to the diagnosis of mTMD. Diagnosing mTMD is based on the recognition of \"familiar pain\" presentation in the masticatory myofascial tissue. This assessment tool contributes little our understanding of the underlying disease process. Thus, management of mTMD is empirical and arbitrary. Exploring emerging technologies to identify biomarkers and objectively assess myofascial tissue physiology in disease and health may be key in moving the diagnosis of mTMD from the pragmatic paradigm to an evidence-based paradigm.

The fast development of biomaterials science and engineering has generated significant number of studies and publications as well as tremendous amount of research data. A methodology is needed to translate such research data and results to validated scientific evidence. This article for the first time proposes the concept and methodology of evidence-based biomaterials research, which is to use evidence-based research approach represented by systematic reviews to generate evidence for answering scientific questions related to biomaterials. After briefly introducing the advancement of biomaterials since 1950s, the scientific and engineering nature of biomaterials are discussed along with the roadmap of biomaterials translation from basic research to commercialized medical products, and the needs of scientific evidence. Key information of the evidence-based approach such as its origination from evidence-based medicine, levels of evidence, systematic review and meta-analysis, differences between systematic and narrative reviews is then highlighted. Applications with a step-by-step procedure of conducting evidence-based biomaterials research, three examples of biomaterials research using evidence-based approach to generate scientific evidence, and opportunities and challenges of evidence-based biomaterials research are presented. With its notable impact on the practice of medicine, the evidence-based approach is also expected to make influential contributions to the biomaterials field.

BACKGROUND: This study aimed to assess senior dental students\' knowledge and attitudes regarding evidence-based dentistry (EBD), their use of the current literature and considerations for patient preferences.
METHODS: A modified Knowledge, Attitudes, Access, and Confidence Evaluation (KACE) survey was administered to collect data from senior dental students at the University of Maryland School of Dentistry (UMSOD). The chi-squared test was used to compare the correct response rates of each question in the knowledge of scientific evidence domain. Spearman\'s rank correlation coefficient was conducted to examine correlations between students\' knowledge of scientific evidence and their confidence in appraising the study qualities.
RESULTS: 61 seniors (out of 130) answered all survey questions. Participants displayed an intermediate level of knowledge of EBD. Only 15% of participants correctly answered to the most appropriate design; the distribution of responses appeared significantly different amongst the questions in the basic knowledge section (chi-squared test, p < .0001). There was no or very weak correlation between students\' knowledge of scientific evidence and their confidence in appraising study qualities (Spearman\'s ρ = 0-0.18). The participants highly valued the use of the current literature and patient preferences. However, their preferred sources of scientific evidence were the Internet excluding Cochrane reviews (60%) and colleagues (56%). Forty per cent of participants rarely or never used textbooks.
CONCLUSIONS: Whilst seniors felt confident in evaluating study qualities and implementing EBD in routine practice, their understanding of the study design was poor. Seniors\' preferred sources of scientific evidence were non-peer-reviewed Internet sources and colleagues.

Though human activities are postulated to be the main drivers of the worldwide biodiversity crisis, humans are also suggested by some to be an important part of the solution to the crisis. How can such a paradox be best solved? This paradox requires an adaptive, context-specific, dynamic solution, at a fine-grained scale that varies by location. The Wild Chimpanzee Foundation (WCF) works on the ground in three West African countries: In Côte d\'Ivoire, where bushmeat consumption is a recurrent and generalized threat to wildlife, WCF used live theater performances in the villages to address this issue. Post-activity evaluations revealed that the more often individuals have been part of such awareness activities, the less they will consume bushmeat. In nearby Liberia, where illegal miners have invaded many protected areas and intact forests, the WCF supports Community Watch Teams (CWT) to patrol the Sapo National Park with Forestry Development Authority staff. Within 11 months of its creation, the CWT patrols around and in the Sapo National Park resulted in thousands of illegal miners progressively leaving the national park. In Guinea, where coexistence between humans and primates has prevailed based on religious traditions, the WCF developed a strategic approach, as the Moyen-Bafing National Park contains about 5000 chimpanzees as well as some 255 villages. Therefore, we adopted an \"integrated landscape approach\" whereby the community activities are planned in combination with initiatives increasing forest regeneration and connectivity in high conservation value areas. Communities in northern Guinea confronted with dramatic fluctuations due to climatic changes welcomed such activities that help them become more resilient and adaptable to those alterations. In conclusion, evidence-based information at the local level helps to resolve the conservation paradox by adapting with the local communities\' context-specific dynamic approaches to enhance the conservation of great apes.

Determining the eligibility of principal investigators (PIs) is a challenging task, especially at an academic institution. The prevailing practice within the academic community is not to grant PI status to students. There is a lack of studies that have investigated students\' eligibility to serve as PI. This study aimed to explore the faculty and students\' perceptions of the PI eligibility of medical students. A secondary objective was to assist the university in developing an evidence-based PI eligibility policy. To achieve the study aims, the investigators developed and validated a survey that targeted both faculty and students of Alfaisal University, College of Medicine (COM). In total, 53 faculty (four were administrators), and 135 medical students responded. The response rates were approximately 50% and 12% for faculty and students, respectively. Of the faculty, 62% reported that medical students are not PI eligible without the supervision of a faculty member. Of the students, 77% reported that they were not qualified to serve as PI. The results of the current study support the practice at most universities of not allowing medical students to serve as PI.

A clinical pathway is one of the tools used to support clinical decision making that provides a standardized care process in a specific context. The objective of this research was to develop a method for building data-driven clinical pathways using electronic health record data.
We proposed a matching rate-based clinical pathway mining algorithm that produces the optimal set of clinical orders for each clinical stage by employing matching rates. To validate the approach, we utilized two different datasets of deidentified inpatient records directly related to total laparoscopic hysterectomy (TLH) and rotator cuff tears (RCTs) from a hospital in South Korea. The derived data-driven clinical pathways were evaluated with knowledge-based models by health professionals using a delta analysis.
Two different data-driven clinical pathways, i.e., TLH and RCTs, were produced by applying the matching rate-based clinical pathway mining algorithm. We identified that there were significant differences in clinical orders between the data-driven and knowledge-based models. Additionally, the data-driven clinical pathways based on our algorithm outperformed the models by clinical experts, with average matching rates of 82.02% and 79.66%, respectively.
The proposed algorithm will be helpful for supporting clinical decisions and directly applicable in medical practices.

The opinion article \"An Evidence-based Perspective on Misconceptions Regarding Pediatric Auditory Processing Disorder\" by Neijenhuis et al. (1) presents a distorted view of the evidence-based approach used in medicine. The authors focus on the amorphous non-diagnostic entity \"listening difficulties\" not auditory processing disorder (APD) and create confusion that could jeopardize clinical services to individuals with APD. In our perspective article, we rebut Neijenhuis et al. (1), and more importantly, we present a rationale for evidence-based practice founded on the premise that research on APD is only clinically applicable when conducted on clinical populations diagnosed with APD.