目的:推论放电(CD)机制抑制自我产生的语音声音感知,在精神分裂症中出现中断,并可能导致异常自我体验(ASEs)。然而,目前尚不清楚这种改变及其与ASEs的相关性是否延伸到其他精神病性障碍.
方法:脑电图用于研究N1事件相关电位(ERP),作为35名精神分裂症患者听觉皮层CD介导抑制的指标,26岁的双相情感障碍患者,和30个健康对照。听觉N1是由两个条件引起的:通过连接的麦克风和耳机讲话时实时收听自发音的元音(听/说话-或先前文献中的说话条件)和被动收听相同的先前录制的自发音元音(听/不说话-或听条件-)。
结果:在所有组中,与听/不说话相比,在听/说话条件下N1ERP幅度较低。然而,在精神分裂症中N1抑制显著减少,双相情感障碍患者在两组之间表现出中等衰减(即,与对照组无显著差异)。此外,仅在精神分裂症中,N1抑制与ASEs严重程度呈负相关。
结论:CD机制的功能障碍可能是精神分裂症的定义特征,它连接到ASES的地方。
结论:这些结果证实了先前的发现,将精神分裂症中的听觉N1ERP抑制与CD机制破坏联系起来,但不是双相情感障碍。
OBJECTIVE: The Corollary Discharge (CD) mechanism inhibits self-generated speech sound perception, appearing disrupted in schizophrenia and potentially contributing to Anomalous Self-Experiences (ASEs). However, it remains unclear if this alteration and its correlation with ASEs extend to other psychotic disorders.
METHODS: Electroencephalography was used to study the N1 Event-Related Potential (ERP) as an index of CD-mediated suppression in the auditory cortex across thirty-five participants with schizophrenia, twenty-six with bipolar disorder, and thirty healthy controls. Auditory N1 was elicited by two conditions: real-time listening to self-pronounced vowels while speaking through connected microphone and earphones (listen/talk -or talk condition in previous literature-) and passive listening to the same previously recorded self-uttered vowels (listen/no talk -or listen condition-).
RESULTS: N1 ERP amplitude was lower in the listen/talk condition compared to listen/no talk across all groups. However, N1 suppression was significantly reduced in schizophrenia, with bipolar patients showing intermediate attenuation between both groups (i.e., non-significantly different from controls). Furthermore, N1 suppression inversely correlated with ASEs severity only in schizophrenia.
CONCLUSIONS: Dysfunction of the CD mechanism may be a defining feature of schizophrenia, where it is connected to ASEs.
CONCLUSIONS: These results corroborate previous findings linking auditory N1 ERP suppression with disrupted CD mechanism in schizophrenia, but not in bipolar disorder.