■有机磷(OP)农药与精液质量下降有关,尽管关于协会的规模仍然存在相当多的争论。
■本研究对OP农药对精液质量和男性生殖激素的影响进行了系统综述和荟萃分析。
■本研究是根据系统评价和荟萃分析(PRISMA)方案的首选报告项目进行的。使用组合文本词作为搜索词进行战略搜索。资格标准是根据人口制定的,曝光,比较器,结果,和研究设计(PECOS)框架。提取相关数据,偏差风险由健康评估和翻译办公室(OHAT)工具评估,证据的确定性通过建议分级评估来评估,发展和评价(等级)工作组准则。使用ReviewManager进行定量荟萃分析。
■共有766名男性受试者(349名暴露于OP农药,417名未暴露的对照)被纳入荟萃分析。射精量无显著差异,精液体积,精子多重异常指数,精子,和暴露于OP的受试者与对照相比的白细胞水平。此外,OP农药暴露对血清FSH浓度无显著影响,LH,与未暴露的受试者相比,暴露于OP农药的受试者和睾丸激素。然而,我们发现精子数量显著减少,精子浓度,进行性精子运动性,精子总运动性,与未暴露受试者相比,暴露于OP农药的受试者的精子形态正常。然而,在亚型和敏感性分析后,暴露于OP杀虫剂并没有减少精子数量。此外,经过敏感性分析,OP杀虫剂暴露不会改变进行性精子运动。
■这项研究表明,OP杀虫剂暴露会降低精子数量,浓度,总运动和渐进运动,精子形态正常,可能是通过不依赖睾酮的机制。
UNASSIGNED: Organophosphate (OP) pesticides have been associated with a decline in semen quality, although there are still considerable arguments about the magnitude of the association.
UNASSIGNED: This study provides a systematic review and meta-analysis of the impacts of OP pesticides on semen quality and male reproductive hormones.
UNASSIGNED: This study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocols. Strategic search was conducted using combined text words as search terms. The eligibility criteria were developed based on Population, Exposure, Comparator, Outcome, and Study designs (PECOS) framework. Relevant data were extracted, risk of bias was evaluated by The Office of Health Assessment and Translation (OHAT) tool, and certainty of evidence was assessed by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group guidelines. Quantitative meta-analysis was performed by using Review Manager.
UNASSIGNED: A total of 766 male subjects (349 exposed to OP pesticides and 417 unexposed controls) were included in the meta-analysis. There was no significant difference in the ejaculate volume, seminal fluid volume, sperm multiple anomaly index, sperm, and leukocytes levels of the OP-exposed subjects compared to the control. In addition, OP pesticides exposure did not significantly affect serum concentrations of FSH, LH, and testosterone in subjects who were exposed to OP pesticides compared to their unexposed counterparts. However, we found a significant reduction in the sperm count, sperm concentration, progressive sperm motility, total sperm motility, and normal sperm morphology of OP pesticides-exposed subjects compared to the unexposed subjects. However, after subtype and sensitivity analyses, exposure to OP pesticides did not reduce sperm count. Also, after sensitivity analysis, OP pesticides exposure did not alter progressive sperm motility.
UNASSIGNED: This study demonstrates that OP pesticides exposure reduced sperm count, concentration, total and progressive motility, and normal sperm morphology, possibly via a testosterone-independent mechanism.