OBJECTIVE: This study aims to develop an ensemble machine learning-based (EML-based) risk prediction model for radiation dermatitis (RD) in patients with head and neck cancer undergoing proton radiotherapy, with the goal of achieving superior predictive performance compared to traditional models.
METHODS: Data from 57 head and neck cancer patients treated with intensity-modulated proton therapy at Kaohsiung Chang Gung Memorial Hospital were analyzed. The study incorporated 11 clinical and 9 dosimetric parameters. Pearson\'s correlation was used to eliminate highly correlated variables, followed by feature selection via LASSO to focus on potential RD predictors. Model training involved traditional logistic regression (LR) and advanced ensemble methods such as Random Forest and XGBoost, which were optimized through hyperparameter tuning.
RESULTS: Feature selection identified six key predictors, including smoking history and specific dosimetric parameters. Ensemble machine learning models, particularly XGBoost, demonstrated superior performance, achieving the highest AUC of 0.890. Feature importance was assessed using SHAP (SHapley Additive exPlanations) values, which underscored the relevance of various clinical and dosimetric factors in predicting RD.
CONCLUSIONS: The study confirms that EML methods, especially XGBoost with its boosting algorithm, provide superior predictive accuracy, enhanced feature selection, and improved data handling compared to traditional LR. While LR offers greater interpretability, the precision and broader applicability of EML make it more suitable for complex medical prediction tasks, such as predicting radiation dermatitis. Given these advantages, EML is highly recommended for further research and application in clinical settings.

Source and raw water quality may deteriorate due to rainfall and river flow events that occur in watersheds. The effects on raw water quality are normally detected in drinking water treatment plants (DWTPs) with a time-lag after these events in the watersheds. Early warning systems (EWSs) in DWTPs require models with high accuracy in order to anticipate changes in raw water quality parameters. Ensemble machine learning (EML) techniques have recently been used for water quality modeling to improve accuracy and decrease variance in the outcomes. We used three decision-tree-based EML models (random forest [RF], gradient boosting [GB], and eXtreme Gradient Boosting [XGB]) to predict two critical parameters for DWTPs, raw water Turbidity and UV absorbance (UV254), using rainfall and river flow time series as predictors. When modeling raw water turbidity, the three EML models (rRF-Tu2=0.87, rGB-Tu2=0.80 and rXGB-Tu2=0.81) showed very good performance metrics. For raw water UV254, the three models (rRF-UV2=0.89, rGB-UV2=0.85 and rXGB-UV2=0.88) again showed very good performance metrics. Results from this study suggest that EML approaches could be used in EWSs to anticipate changes in the quality parameters of raw water and enhance decision-making in DWTPs.

This study proposed an intelligent model for predicting abiotic stress-responsive microRNAs in plants. MicroRNAs (miRNAs) are short RNA molecules regulates the stress in genes. Experimental methods are costly and time-consuming, as compare to in-silico prediction. Addressing this gap, the study seeks to develop an efficient computational model for plant stress response prediction. The two benchmark datasets for MiRNA and Pre-MiRNA dataset have been acquired in this study. Four ensemble approaches such as bagging, boosting, stacking, and blending have been employed. Classifiers such as Random Forest (RF), Extra Trees (ET), Ada Boost (ADB), Light Gradient Boosting Machine (LGBM), and Support Vector Machine (SVM). Stacking and Blending employed all stated classifiers as base learners and Logistic Regression (LR) as Meta Classifier. There have been a total of four types of testing used, including independent set, self-consistency, cross-validation with 5 and 10 folds, and jackknife. This study has utilized evaluation metrics such as accuracy score, specificity, sensitivity, Mathew\'s correlation coefficient (MCC), and AUC. Our proposed methodology has outperformed existing state of the art study in both datasets based on independent set testing. The SVM-based approach has exhibited accuracy score of 0.659 for the MiRNA dataset, which is better than the previous study. The ET classifier has surpassed the accuracy of Pre-MiRNA dataset as compared to the existing benchmark study, achieving an impressive score of 0.67. The proposed method can be used in future research to predict abiotic stresses in plants.

The aim of the study was to estimate future groundwater potential zones based on machine learning algorithms and climate change scenarios. Fourteen parameters (i.e., curvature, drainage density, slope, roughness, rainfall, temperature, relative humidity, lineament density, land use and land cover, general soil types, geology, geomorphology, topographic position index (TPI), topographic wetness index (TWI)) were used in developing machine learning algorithms. Three machine learning algorithms (i.e., artificial neural network (ANN), logistic model tree (LMT), and logistic regression (LR)) were applied to identify groundwater potential zones. The best-fit model was selected based on the ROC curve. Representative concentration pathways (RCP) of 2.5, 4.5, 6.0, and 8.5 climate scenarios of precipitation were used for modeling future climate change. Finally, future groundwater potential zones were identified for 2025, 2030, 2035, and 2040 based on the best machine learning model and future RCP models. According to findings, ANN shows better accuracy than the other two models (AUC: 0.875). The ANN model predicted that 23.10 percent of the land was in very high groundwater potential zones, whereas 33.50 percent was in extremely high groundwater potential zones. The study forecasts precipitation values under different climate change scenarios (RCP2.6, RCP4.5, RCP6, and RCP8.5) for 2025, 2030, 2035, and 2040 using an ANN model and shows spatial distribution maps for each scenario. Finally, sixteen scenarios were generated for future groundwater potential zones. Government officials may utilize the study\'s results to inform evidence-based choices on water management and planning at the national level.

UNASSIGNED: Our objectives were to (1) employ ensemble machine learning algorithms utilizing real-world clinical data to predict 90-day prognosis, including dialysis dependence and mortality, following the first hospitalized dialysis and (2) identify the significant factors associated with overall outcomes.
UNASSIGNED: We identified hospitalized patients with Acute kidney injury requiring dialysis (AKI-D) from a dataset of the Taipei Medical University Clinical Research Database (TMUCRD) from January 2008 to December 2020. The extracted data comprise demographics, comorbidities, medications, and laboratory parameters. Ensemble machine learning models were developed utilizing real-world clinical data through the Google Cloud Platform.
UNASSIGNED: The Study Analyzed 1080 Patients in the Dialysis-Dependent Module, Out of Which 616 Received Regular Dialysis After 90 Days. Our Ensemble Model, Consisting of 25 Feedforward Neural Network Models, Demonstrated the Best Performance with an Auroc of 0.846. We Identified the Baseline Creatinine Value, Assessed at Least 90 Days Before the Initial Dialysis, as the Most Crucial Factor. We selected 2358 patients, 984 of whom were deceased after 90 days, for the survival module. The ensemble model, comprising 15 feedforward neural network models and 10 gradient-boosted decision tree models, achieved superior performance with an AUROC of 0.865. The pre-dialysis creatinine value, tested within 90 days prior to the initial dialysis, was identified as the most significant factor.
UNASSIGNED: Ensemble machine learning models outperform logistic regression models in predicting outcomes of AKI-D, compared to existing literature. Our study, which includes a large sample size from three different hospitals, supports the significance of the creatinine value tested before the first hospitalized dialysis in determining overall prognosis. Healthcare providers could benefit from utilizing our validated prediction model to improve clinical decision-making and enhance patient care for the high-risk population.

Due to the intricate relationship between the small non-coding ribonucleic acid (miRNA) sequences, the classification of miRNA species, namely Human, Gorilla, Rat, and Mouse is challenging. Previous methods are not robust and accurate. In this study, we present AtheroPoint\'s GeneAI 3.0, a powerful, novel, and generalized method for extracting features from the fixed patterns of purines and pyrimidines in each miRNA sequence in ensemble paradigms in machine learning (EML) and convolutional neural network (CNN)-based deep learning (EDL) frameworks. GeneAI 3.0 utilized five conventional (Entropy, Dissimilarity, Energy, Homogeneity, and Contrast), and three contemporary (Shannon entropy, Hurst exponent, Fractal dimension) features, to generate a composite feature set from given miRNA sequences which were then passed into our ML and DL classification framework. A set of 11 new classifiers was designed consisting of 5 EML and 6 EDL for binary/multiclass classification. It was benchmarked against 9 solo ML (SML), 6 solo DL (SDL), 12 hybrid DL (HDL) models, resulting in a total of 11 + 27 = 38 models were designed. Four hypotheses were formulated and validated using explainable AI (XAI) as well as reliability/statistical tests. The order of the mean performance using accuracy (ACC)/area-under-the-curve (AUC) of the 24 DL classifiers was: EDL > HDL > SDL. The mean performance of EDL models with CNN layers was superior to that without CNN layers by 0.73%/0.92%. Mean performance of EML models was superior to SML models with improvements of ACC/AUC by 6.24%/6.46%. EDL models performed significantly better than EML models, with a mean increase in ACC/AUC of 7.09%/6.96%. The GeneAI 3.0 tool produced expected XAI feature plots, and the statistical tests showed significant p-values. Ensemble models with composite features are highly effective and generalized models for effectively classifying miRNA sequences.

Combining the results of base models to create a meta-model is one of the ensemble approaches known as stacking. In this study, stacking of five base learners, including eXtreme gradient boosting, random forest, feed-forward neural networks, generalized linear models with Lasso or Elastic Net regularization, and support vector machines, was used to study the spatial variation of Mn, Cd, Pb, and nitrate in Qom-Kahak Aquifers, Iran. The stacking strategy proved to be an effective substitute predictor for existing machine learning approaches due to its high accuracy and stability when compared to individual learners. Contrarily, there was not any best-performing base model for all of the involved parameters. For instance, in the case of cadmium, random forest produced the best results, with adjusted R2 and RMSE of 0.108 and 0.014, as opposed to 0.337 and 0.013 obtained by the stacking method. The Mn and Cd showed a tight link with phosphate by the redundancy analysis (RDA). This demonstrates the effect of phosphate fertilizers on agricultural operations. In order to analyze the causes of groundwater pollution, spatial methodologies can be used with multivariate analytic techniques, such as RDA, to help uncover hidden sources of contamination that would otherwise go undetected. Lead has a larger health risk than nitrate, according to the probabilistic health risk assessment, which found that 34.4% and 6.3% of the simulated values for children and adults, respectively, were higher than HQ = 1. Furthermore, cadmium exposure risk affected 84% of children and 47% of adults in the research area.

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BACKGROUND: Ticks are an important driver of veterinary health care, causing irritation and sometimes infection to their hosts. We explored epidemiological and geo-referenced data from > 7 million electronic health records (EHRs) from cats and dogs collected by the Small Animal Veterinary Surveillance Network (SAVSNET) in Great Britain (GB) between 2014 and 2021 to assess the factors affecting tick attachment in an individual and at a spatiotemporal level.
METHODS: EHRs in which ticks were mentioned were identified by text mining; domain experts confirmed those with ticks on the animal. Tick presence/absence records were overlaid with a spatiotemporal series of climate, environment, anthropogenic and host distribution factors to produce a spatiotemporal regression matrix. An ensemble machine learning spatiotemporal model was used to fine-tune hyperparameters for Random Forest, Gradient-boosted Trees and Generalized Linear Model regression algorithms, which were then used to produce a final ensemble meta-learner to predict the probability of tick attachment across GB at a monthly interval and averaged long-term through 2014-2021 at a spatial resolution of 1 km. Individual host factors associated with tick attachment were also assessed by conditional logistic regression on a matched case-control dataset.
RESULTS: In total, 11,741 consultations were identified in which a tick was recorded. The frequency of tick records was low (0.16% EHRs), suggesting an underestimation of risk. That said, increased odds for tick attachment in cats and dogs were associated with younger adult ages, longer coat length, crossbreeds and unclassified breeds. In cats, males and entire animals had significantly increased odds of recorded tick attachment. The key variables controlling the spatiotemporal risk for tick attachment were climatic (precipitation and temperature) and vegetation type (Enhanced Vegetation Index). Suitable areas for tick attachment were predicted across GB, especially in forests and grassland areas, mainly during summer, particularly in June.
CONCLUSIONS: Our results can inform targeted health messages to owners and veterinary practitioners, identifying those animals, seasons and areas of higher risk for tick attachment and allowing for more tailored prophylaxis to reduce tick burden, inappropriate parasiticide treatment and potentially TBDs in companion animals and humans. Sentinel networks like SAVSNET represent a novel complementary data source to improve our understanding of tick attachment risk for companion animals and as a proxy of risk to humans.

Comprehensively projecting global fertilizer consumption is essential for providing critical datasets in related fields such as earth system simulation, the fertilizer industry, and agricultural sciences. However, since previous studies have not fully considered the socioeconomic factors affecting fertilizer consumption, huge uncertainties may remain in fertilizer consumption projections. Here, an approach ensembled six machine learning algorithms was proposed in this study to predict global fertilizer consumption from 2020 to 2100 by considering the impact of socioeconomic factors under shared socioeconomic pathway (SSP) scenarios. It indicates that the proposed approach provides a rational and reliable framework for fertilizer consumption prediction that stably outperforms the single algorithms with relatively high accuracy (Nash-Sutcliffe efficiency of 0.93, Kling-Gupta efficiency of 0.89, and mean absolute percentage error of 10.97 %). We found that global N and P fertilizer consumption may decrease from 2020 to 2100, while K fertilizer may buck the trend. N fertilizer consumption showed a declining trend of -1 %, -17.13 %, and -3.43 % under the SSP1, SSP2, and SSP3 scenarios in 2100, respectively. For P fertilizer, those were -0.68 %, -9.68 %, and -2.03 %. In contrast, global K fertilizer consumption may increase by 18.03 %, 9.18 %, and 6.74 %, respectively. On average, N, P, and K fertilizer consumption is highest in China, and the lowest is in Kazakhstan. However, the hotspots of N fertilizer consumption may shift from China to Latin America and the Caribbean. This study highlighted the ensemble machine learning approach could potentially be a robust method for predicting future fertilizer consumption. Our prediction product will not only contribute to a better understanding of global fertilizer consumption trends and dynamics but also provide flexible and accurate key data/parameters for related research. The Projected Global Fertilizers Consumption Datasets are available at doi:https://doi.org/10.5281/zenodo.8195593 (Gao et al., 2023).