engineering

Engineering
  • 文章类型: Journal Article
    伦理学是科学和工程研究与实践的核心,但是,促进学生道德形成的一个关键挑战是提高教职员工的能力和信心,将积极的道德学习经验嵌入到他们的课程中。为此,本文探讨了教师参与多年跨学科教师学习社区(FLC)后,他们对道德教育的方法和看法的变化。在FLC第二年之后,我们对11名参与者进行了半结构化访谈,并进行了主题分析。定性主题表明,经过两年的FLC参与,教职员工(1)能够更好地阐述他们对道德的概念化;(2)认识到个人经历,视图,和信念告知他们如何将道德引入他们的课程;和(3)发展和实践指导他们的道德教学的教学原则。因此,结果表明,教师从探索中受益,讨论,和道德教学,这(反过来)使他们能够看到新的机会,并有信心以符合他们学术身份的有意义的方式将道德融入他们的课程。一起来看,这些数据表明教师成为设计变革的推动者,实施,并完善STEM中与道德相关的教学工作。这项工作可以指导其他有兴趣设计教师学习社区的人,以促进教学技能的发展,教职员工对他们的道德价值观的认识,以及他们以有意和持续的方式与部门同行一起设计和整合道德学习活动的能力和机构。
    Ethics is central to scientific and engineering research and practice, but a key challenge for promoting students\' ethical formation involves enhancing faculty members\' ability and confidence in embedding positive ethical learning experiences into their curriculums. To this end, this paper explores changes in faculty members\' approaches to and perceptions of ethics education following their participation in a multi-year interdisciplinary faculty learning community (FLC). We conducted and thematically analyzed semi-structured interviews with 11 participants following the second year of the FLC. Qualitative themes suggested that, following two years of FLC participation, faculty members (1) were better able to articulate their conceptualizations of ethics; (2) became cognizant of how personal experiences, views, and beliefs informed how they introduced ethics into their curriculum; and (3) developed and lived instructional principles that guided their ethics teaching. Results thus suggested that faculty members benefitted from exploring, discussing, and teaching ethics, which (in turn) enabled them to see new opportunities and become confident in integrating ethics into their courses in meaningful ways that aligned with their scholarly identities. Taken together, these data suggest faculty became agents of change for designing, implementing, and refining ethics-related instructional efforts in STEM. This work can guide others interested in designing faculty learning communities to promote instructional skill development, faculty members\' awareness of their ethical values, and their ability and agency to design and integrate ethics learning activities alongside departmental peers in an intentional and continuous manner.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    这项实证研究旨在确定在孟加拉国多元文化的国际机构注册的工程专业学生的满意度,并享有卓越的声誉。通过完成在线调查,各种一年级和四年级本科生参加了这项研究。这项研究的重点是选定的决定因素,即;支持服务(SS),校园生活(CL),经济因素(EF)和大学企业形象(CI)。研究人员使用调查研究设计(SRD)来阐明学生的意见和观点。多元回归分析(MRA)用于回归326名参与研究的受访者的意见。采用不成比例分层随机抽样确定样本。这项研究以两个假设为指导。该研究通过使用标准多元回归分析了学生对学术服务满意度的预测因素。研究结果表明,四个决定因素SS,CL,EF和CI在预测学生满意度方面具有统计学意义[F(4,321)=143.786,p<.001]。根据经验发现,支持服务对模型的影响最大[β=.496,p<.05],其次是大学企业形象[β=.365,p<.05]。研究结果表明,校园生活和经济因素在预测因素模型中没有统计学意义(p>.05),这意味着它们不会影响学生对大学学术生涯的满意度。研究人员建议,为了保持学生对学术经历的满意度,大学应巩固向学生提供的支持服务,并改善他们的企业形象和世界观。
    This empirical study sought to determine the levels of satisfaction among engineering students enrolled at a multicultural international institution in Bangladesh with a reputation for excellence. An assortment of first- and fourth-year undergraduate students participated in the study by completing an online survey. The study focused on selected determinants namely; support services (SS), campus life (CL), economic factors (EF) and University corporate image (CI). The researchers used a survey research design (SRD) to illuminate students\' opinions and views. A multiple regression analysis (MRA) was used to regress opinions of 326 respondents who participated in the study. The disproportional stratified random sampling was used to determine the samples. The study was guided by two hypotheses. The study analyzed predictors of student satisfaction with academic services by employing standard multiple regression analysis. The findings showed that the four determinants SS, CL, EF and CI were statistically significant to predict students\' satisfaction levels [F(4,321) = 143.786, p < .001]. It was empirically discovered that Support Services had the highest impact to the model [β = .496, p < .05] followed by university Corporate Image [β = .365, p < .05]. The findings showed that Campus Life and Economic Factors were not statistically significant (p>.05) in the model of predictors implying that they do not influence students\' satisfaction levels on their academic career at the university. The researchers recommend that in order to maintain students\' satisfaction levels on their academic experiences, universities should consolidate on support services provided to the students as well as improving their corporate image and world view.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    暂无摘要。
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    基于巨噬细胞的细胞疗法是治疗癌症和修复组织损伤的新兴方式。可重复的制造和工程过程是实现其治疗潜力的核心。这里,我们建立了一个强大的巨噬细胞制造平台(Mo-Mac),并证明N1-甲基假尿苷(m1kW)修饰的mRNA可以增强巨噬细胞功能.使用单细胞转录组学分析作为一种无偏方法,我们发现最终产物中90%以上的细胞是巨噬细胞,而其余的主要是T细胞,B细胞,自然杀伤细胞,早幼粒细胞,前单核细胞,和造血干细胞。该分析还指导了流式细胞术策略的开发,以评估制造产品中的细胞组成,以满足国家医疗产品管理局的要求。为了调节巨噬细胞功能,作为一个说明性的例子,我们检查了mRNA技术是否可以增强巨噬细胞的吞噬能力。我们发现,当用编码CD300LF(CD300LF-mRNA-巨噬细胞)的m1kW修饰的mRNA电穿孔时,巨噬细胞体外的胞增作用增加。始终如一,在急性肝衰竭小鼠模型中,CD300LF-mRNA-巨噬细胞促进对乙酰氨基酚诱导的肝毒性的器官恢复。这些结果证明了符合GMP的巨噬细胞制造过程,并表明巨噬细胞可以通过通用mRNA技术进行工程改造以实现治疗目标。
    Macrophage-based cell therapeutics is an emerging modality to treat cancer and repair tissue damage. A reproducible manufacturing and engineering process is central to fulfilling their therapeutic potential. Here, we establish a robust macrophage-manufacturing platform (Mo-Mac) and demonstrate that macrophage functionality can be enhanced by N1-methylpseudouridine (m1Ψ)-modified mRNA. Using single-cell transcriptomic analysis as an unbiased approach, we found that >90% cells in the final product were macrophages while the rest primarily comprised T cells, B cells, natural killer cells, promyelocytes, promonocytes, and hematopoietic stem cells. This analysis also guided the development of flow-cytometry strategies to assess cell compositions in the manufactured product to meet requirements by the National Medical Products Administration. To modulate macrophage functionality, as an illustrative example we examined whether the engulfment capability of macrophages could be enhanced by mRNA technology. We found that efferocytosis was increased in vitro when macrophages were electroporated with m1Ψ-modified mRNA encoding CD300LF (CD300LF-mRNA-macrophage). Consistently, in a mouse model of acute liver failure, CD300LF-mRNA-macrophages facilitated organ recovery from acetaminophen-induced hepatotoxicity. These results demonstrate a GMP-compliant macrophage-manufacturing process and indicate that macrophages can be engineered by versatile mRNA technology to achieve therapeutic goals.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    对废物管理和可持续能源需求的担忧不断升级,促使资源回收和自供电应用的创新解决方案。这项研究提出了一种新的方法,可以从废弃的尿布和废弃的烤盘中回收超吸收聚合物(SAP)凝胶,以制造基于尿布废物的摩擦电纳米发电机(DW-TENG)。DW-TENG,像一个马拉卡,具有110V的电压输出,具有出色的电气性能,电流为9μA,和259.15μW的功率。它成功地集成到一个自供电气象站中,用于实时监测风速,湿度,湿度和温度。这项研究强调了废物管理和能源生产的双重好处,代表着朝着循环和可持续的未来迈出了有希望的一步。
    Escalating concerns over waste management and the need for sustainable energy have prompted innovative solutions at the nexus of resource recycling and self-powered applications. This study presents a novel approach to recycling super-absorbing polymer (SAP) gels from waste diapers and discarded baking sheets to fabricate a diaper waste-based triboelectric nanogenerator (DW-TENG). The DW-TENG, resembling a maraca, demonstrated superior electrical performance with a voltage output of 110 V, a current of 9 μA, and a power of 259.15 μW. It was successfully integrated into a self-powered weather station for real-time monitoring of wind speed, humidity, and temperature. This research underscores the dual benefits of waste management and energy generation, representing a promising step toward a circular and sustainable future.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: News
    暂无摘要。
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    建筑业是中国乃至全球缓解气候变化不可或缺的一部分。通过考虑绿色创新的影响,我们探讨了中国建筑行业碳排放的长期趋势,直到2060年,包括其整个生命周期。结果表明,在一切照旧(BAU)情景下,中国建筑业的CO2排放量将在2035年达到6.98-7.69Bt的峰值,并在2060年保持在1.11Bt。“3060双碳目标”只有在技术突破(TB)的情况下才能实现。这些发现表明,现有或相对宽松的政策不足以实现建筑业的“3060”目标。中国应在建筑行业的整个生命周期中积极追求绿色技术创新,重点加快重点产品的绿色低碳生产,如钢铁和水泥,在建材生产阶段。
    The building sector is integral to climate change mitigation in China as well as the globe. By considering the impact of green innovation, we explore the long-term trend of carbon emissions in China\'s building sector until 2060, encompassing its entire life cycle. Results show that CO2 emissions of China\'s building sector will peak at 6.98-7.69 Bt in 2035 and maintain at 1.11 Bt in 2060 under the business-as-usual (BAU) scenario. The \"3060 dual carbon goal\" will only be achieved under the technological breakthrough (TB) scenario. These findings show that existing or relatively lax policies are insufficient to achieve the \"3060\" goal for the building sector. China should actively pursue green technological innovation throughout the building sector\'s life cycle, with a focus on accelerating the green and low-carbon production of key products, such as steel and cement, at the building material production stage.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: News
    暂无摘要。
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: News
    暂无摘要。
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    从个人主义的角度对研究人员的伦理决策进行了历史研究。然而,研究人员很少单独工作,他们通常会在团队环境中遇到道德困境。在这项混合方法研究中,在美国公立R1(非常高的研究活动)大学工作的67名科学家和工程师回答了一项调查,该调查询问他们在研究团队工作时是否经历或观察到道德困境。其中,30名受访者同意接受采访,了解他们使用大声思考协议的经历。在这些采访中,共收集了40起独特的道德事件。然后,多位独立法官对访谈笔录中的定性数据进行了系统的内容分析,以量化团队决策的整体道德以及几个团队特征,决策过程,和情境因素。结果表明,团队形式主义取向,道德拥护,道德决策策略的使用都与团队决策的整体道德呈正相关。此外,道德拥护与整体团队决策道德之间的关系受到心理安全性和道德强度的调节。讨论了对未来研究和实践的启示。
    The ethical decision making of researchers has historically been studied from an individualistic perspective. However, researchers rarely work alone, and they typically experience ethical dilemmas in a team context. In this mixed-methods study, 67 scientists and engineers working at a public R1 (very high research activity) university in the United States responded to a survey that asked whether they had experienced or observed an ethical dilemma while working in a research team. Among these, 30 respondents agreed to be interviewed about their experiences using a think-aloud protocol. A total of 40 unique ethical incidents were collected across these interviews. Qualitative data from interview transcripts were then systematically content-analyzed by multiple independent judges to quantify the overall ethicality of team decisions as well as several team characteristics, decision processes, and situational factors. The results demonstrated that team formalistic orientation, ethical championing, and the use of ethical decision strategies were all positively related to the overall ethicality of team decisions. Additionally, the relationship between ethical championing and overall team decision ethicality was moderated by psychological safety and moral intensity. Implications for future research and practice are discussed.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

公众号